THE INFLUENCE OF CORONARY BYPASS ON ENDOTHELIAL AND ERECTILE DYSFUNCTION IN ISCHEMIC HEART DISEASE by S. A. Pomeshkina, E. V. Pomeshkin, T. Yu. Sergeeva, I. N. Sizova, O. L. Barbarash

Get full text

ASSOCIATION OF DEPRESSION AND ERECTILE DYSFUNCTION IN CARDIAC PATIENTS by S. A. Pomeshkina

“…The manifestations of the cause-effect relationship between ED and depression could vary: ED might be a symptom of depression, while depression could also be caused by ED, and the improvement in erectile function can reduce the severity of depressive symptoms. …”
Get full text

Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases by Meng Zhang, Jin Wei, Chang He, Liutao Sui, Chucheng Jiao, Xiaoyan Zhu, Xudong Pan

“…Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. …”
Get full text

Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism. by Ning Cheng, Fawaz Alshammari, Elizabeth Hughes, Maryam Khanbabaei, Jong M Rho

“…Since dendritic structure is critical for information integration and relay, our data suggest that altered development of dendrites could potentially contribute to impaired hippocampal function and behavior observed in the BTBR model, and that this might be related to increased activation of the ERK pathway.…”
Get full text

Bureaucratic Rationalism and The Quiet (R)evolution by William Twining

“…We can of course pump students full of facts or even brainwash them — but pumping facts is a waste of everybody’s time and washing brains in public is, as Justice Holmes might have told us, dirty business. Learning is what students are there for and all we know about learning is that, on any level of complexity, it is every man for himself and by himself, imposing a perhaps delusive formal pattern on the swirling chaos by a prodigious effort of the individual will. …”
Get full text

Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…Recent advances in genomics technologies have spurred unprecedented efforts in genome and exome re-sequencing aiming to unravel the genetic component of rare and complex disorders. While in rare disorders this allowed the identification of novel causal genes, the missing heritability paradox in complex diseases remains so far elusive. …”
Get full text

Exercise: a non-drug strategy of NK cell activation by Huixin Pan, Rui Meng, Zixuan Jia, Jing Zhang, Wen Ma, Youhan Liu, Qinglu Wang, Qiaoqiao Li

“…So far, it is widely believed that moderate exercise can significantly enhance the proliferation and activity of NK cells, strengthening immune function. However, the impact of exercise on NK cells is a dynamic and complex process. …”
Get full text

Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty by Hendri Saputra, Sutanto Soehodho

“…Current problems of concern in aviation safety management involve a series of constraints, evaluation methods, and complex decision-making processes. Uncertainty in these problems adds complexity. …”
Get full text

What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus? by Hujun Shen, Hui Sun, Guohui Li

“…Poliovirus (PV) is a well-characterized RNA virus, and the RNA-dependent RNA polymerase (RdRp) from PV (3D(pol)) has been widely employed as an important model for understanding the structure-function relationships of RNA and DNA polymerases. …”
Get full text

Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…Mortalin dysfunction associated with Parkinson's disease (PD) increases the vulnerability of cultured cells to proteolytic stress and leads to changes in mitochondrial function and morphology. To date, Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes. …”
Get full text

Peripartum Cardiomyopathy-Induced Cardiogenic Shock Causing Hypoxic-Ischemic Encephalopathy in a COVID-19 Patient by Minh Khoi Le, Thanh Hieu Nguyen

“…The etiology of PPCM is not fully elucidated and is probably multifactorial, and viral infection might play some role. It has been documented that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly invades the cardiomyocytes and most commonly damages this vital organ via complex systemic devastating mechanisms. …”
Get full text

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. by Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

“…Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. …”
Get full text

Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. by Thomas J Carney, Natália Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M Gebauer, Jared Coffin Talbot, Charles B Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W Ingham, Matthias Hammerschmidt

“…In addition, the novel genes might prove helpful to unravel the molecular nature of thus far unresolved cases of the human disease.…”
Get full text

Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…As far as we know, no aqueduct had yet come into operation at that time. Conversely, it might have received its water supply from the Yzeron aqueduct at the time when the complex was transformed during the reigns of Tiberius and Claudius. …”
Get full text

Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification by Kartik Balachandran, Philippe Sucosky, Ajit P. Yoganathan

“…Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. …”
Get full text

A conversation on academic freedom and freedom of expression at the university by Robert C. Post, Jordi Pujol

“…At their best, universities function as ‘disciplinary communities’ who must act in professionally competent ways. …”
Get full text

The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases by Núria Mach

“…Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. …”
Get full text

Path Optimization Strategy for Unmanned Aerial Vehicles Based on Improved Black Winged Kite Optimization Algorithm by Shuxin Wang, Bingruo Xu, Yejun Zheng, Yinggao Yue, Mengji Xiong

“…The Black-winged Kite Optimization Algorithm (BKA) is likely to experience a sluggish convergence rate when confronted with the optimization of complex multimodal functions. The fundamental algorithm has a tendency to get stuck in local optima, thus rendering it arduous to identify the global optimal solution. …”
Get full text

Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. by Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays

“…As RPs co-assemble into one multi-subunit complex, mutation of the genes that encode RPs might be expected to give rise to phenocopies, in which the same phenotype is associated with loss-of-function of each individual gene. …”
Get full text

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. by Jennifer H Stuart, Rebecca P Sumner, Yongxu Lu, Joseph S Snowden, Geoffrey L Smith

“…Here we show that vaccinia virus (VACV) strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation, thereby restricting type I IFN production from infected cells. …”
Get full text