Biological pathways leading to septo-optic dysplasia: a review by Ludovica Pasca, Davide Politano, Federica Morelli, Jessica Garau, Sabrina Signorini, Enza Maria Valente, Renato Borgatti, Romina Romaniello

“…Those pathways may converge and thus, the implicated genes may function as cascading regulators at multiple levels. …”
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Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism by Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng

“…SEMAs and its receptors formed a complex network, and other members of the SEMA-signaling pathway might also be involved in the pathogenesis of IHH.…”
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Targeting miR‐223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds by Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, Toshimitsu Komatsu, Seongjoon Park, Yuka Okada, Rina Takahashi, Yayoi Kawano, Takehisa Hanawa, Keisuke Iwasaki, Tadashige Nozaki, Hidetaka Torigoe, Kazuya Ikematsu, Yutaka Suzuki, Katsumi Tanaka, Paul Martin, Isao Shimokawa, Ryoichi Mori

“…Abstract Argonaute 2 bound mature microRNA (Ago2‐miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. …”
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HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome by Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. …”
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Mechanism of intestinal tight junction transmembrane proteins interaction with egg white peptides RVPSL and QIGLF by Zhipeng Yu, Di Liu, Long Ding, Zhiyang Du, Wenzhu Zhao

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Detection of Toxicity of heavy metal pollution in soils based on their respiratory activity in native soils and simulated substrates (a case-study of the protected area “YAMSKAYA s... by N. O. Bakunovich, O. S. Khokhlova, T. N. Myakshina, A. V. Rusakov, A. S. Shapovalov

“…The area “Yamskaya Steppe” of “Belogorye” preserve is located in Belgorod Oblast near the concentration of mining factories: Lebedinskiy and Stoylenskiy mining and concentration complex (MCC), complexes of “KMA-ore” and Oskol metallurgical, TPP etc. …”
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CyTOF as a suitable tool for stratification and monitoring of cancer patients by Barbara Seliger, Chiara Massa

“…Abstract Despite the recent implementation of immunotherapies into clinical practice of various tumor types, the immunobiology of tumors and in particular the role and clinical relevance of the different immune cell populations and their function still remained unclear. Therefore, an in depth analysis of the complex landscape of immune cell populations and their soluble mediators in the peripheral blood and tumor microenvironment of cancer patients is urgently needed. …”
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Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. by Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu

“…Because Vimar could co-immunoprecipitate with Miro in vitro, we speculated that Vimar might be the GEF of Miro. In support of this hypothesis, a loss-of-function (LOF) vimar mutant rescued mitochondrial enlargement induced by a gain-of-function (GOF) Miro transgene; whereas a GOF vimar transgene enhanced Miro function. …”
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Introduction: Melting Point by Sérgio Henrique Faria

“… We might think that high mountain regions, being remote and frozen, would be naturally isolated and protected from human action – the last untouched corners of the planet. …”
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Heterogeneidade nos deficits de percepção do movimento em perturbações do desenvolvimento: o caso do Autismo e da Síndrome de Williams by Ana Maria Abreu, Scania de Schonen

“…Moreover, a different pattern of low level motion detection deficits might underlie each of these developmental disorders. …”
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The Role of miRNA in Plant Adaptation to Abiotic Stress by Mohammad Hadi Taleb, Ahmad Arzani

“…The siRNAs then guide a protein complex called RISC (RNA-induced silencing complex) to complementary mRNA sequences. …”
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DYSFUNCTION OF COMPLEMENT SYSTEM IN FAMILIAL MEDITERRANEAN FEVER by G. M. Mkrtchyan, L. P. Hovhannisyan, A. A. Ayvazyan, E. Y. Nazaretyan, A. S. Boyajyan

“…From the data obtained, following conclusions have been made: 1) pathogenesis of FMF is characterized by a complement dysfunction, including hyperactivation of classical complement pathway and hypoactivation state of alternative pathway; 2) alterations in functional activities of classical and alternative complement activation pathways in FMF are interdependent; 3) the alternative pathway is suppressed on the initial stage of its activation; 4) high blood levels of C-reactive protein, serum amyloid P component, and circulating immune complexes, associated with FMF, might be responsible for hyperactivation of classical complement pathway in this disease.…”
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A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. by Eoin N Leen, Frédéric Sorgeloos, Samantha Correia, Yasmin Chaudhry, Fabien Cannac, Chiara Pastore, Yingqi Xu, Stephen C Graham, Stephen J Matthews, Ian G Goodfellow, Stephen Curry

“…These observations define important structural details of a functional interaction between norovirus VPg and eIF4G and reveal a binding interface that might be exploited as a target for antiviral therapy.…”
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Chromatin binding and silencing: Two roles of the same protein Lem2 by Ramón Ramos Barrales, Sigurd Braun

“…This further unveils a complex function of this protein at the interface between the nuclear periphery and silent chromatin, which might be preserved among the other members of this conserved family of LEM proteins.…”
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Discipline-based Teaching and Identity Expansion – Teacher Education and the Tertiary Vocational Educator in New Zealand by Lisa Maurice-Takerei, Helen Anderson

“…With diverse work-based backgrounds, vocational educators undertake their work within the teaching workforce often without a strong sense of their educational position or function and there is little guidance in the complexities and realities of the role. …”
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The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. by Aymeric P Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M J Lilley, Shawn Ahmed, Anton Gartner

“…Furthermore, GEN-1 acts redundantly with the 9-1-1 complex to ensure genome stability. Our study suggests that GEN-1 might act as a dual function Holliday junction resolvase that may coordinate DNA damage signaling with a late step in DNA double-strand break repair.…”
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Acute Childhood Cardiorenal Syndrome and Impact of Cardiovascular Morbidity on Survival by Wasiu A. Olowu

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Ray Tracing Methods for Correcting Chromatic Aberrations in Imaging Systems by Dmitry Reshidko, Masatsugu Nakanato, José Sasián

“…While the use of aberration formulas might be effective for some simple optical systems, it has limitations for complex and fast systems. …”
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A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder by Adriano Alberti, Willians Fernando Vieira, David Richer Araujo Coelho, Daniel Fernandes Martins

“…The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. …”
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Socio‑Economic Determinants of Construction Sector Development by Florian Gerth, Martin O’Brien, Karol S. Sikora

“…To do this, the study conducts a combination of regression analyses, Ordinary Least Squares in conjunction with Methods-of-Moments, while applying rigor to guarantee compliance with the CLR function assumptions. We find that the link between economic development and activity in construction is more complex than previously believed, with the role of the construction industry changing during economic development. …”
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