SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice by Ziying Jiang, Bin Liu, Tangsheng Lu, Xiaoxing Liu, Renjun Lv, Kai Yuan, Mengna Zhu, Xinning Wang, Shangbin Li, Song Xu, Xinyu Wang, Yifei Wang, Zhenfang Gao, Peiqing Zhao, Zongyong Zhang, Junwei Hao, Lin Lu, Qingqing Yin

“…More in-depth analysis of oligodendrocytes (OLs) distinguished five subclusters, indicating different functional states of OLs and transcriptional changes in each subcluster. …”
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Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling by Joann Phan, Suneer Jain, Jurgen F. Nijkamp, Rajkumar Sasidharan, Ashish Agarwal, Julia K. Bird, Anneleen Spooren, Jonas Wittwer Schegg, Emiel Ver Loren van Themaat, Tim N. Mak

“…ABSTRACT Despite the complexity of the gut microbiome, several scores that use taxonomic characteristics exist that attempt to identify a healthy gut or gastrointestinal disease. …”
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Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Effic... by Shadi Jacob Khoury, Yazeed Zoabi, Mickey Scheinowitz, Noam Shomron

“…The results suggest that booster shots might be necessary for this population to ensure adequate immunity, given the observed immune response patterns. …”
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Abstract 157: Evaluating the Impact of Pre‐Procedural CTA on Fluoroscopy Time and Conversion Rates by Zachary Lodato, Ivo Bach, Humza Haque, Elan Meltzer, Priyank Khandelwal

“…Introduction Cerebral angiography, essential in managing cerebrovascular disorders, exposes patients to ionizing radiation, with dose dependence on procedure complexity, patient's body habitus, and equipment used, raising safety concerns (1,2). …”
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Cycloserine resistance among drug-resistant tuberculosis cases in Taiwan by Sheng-Han Wu, Hsin-Yi Liu, Kuang-Hung Liu, Hseuh-Chien Hsiao, Ruwen Jou

“…Of the 114 MTBC isolates, we found 5 (4.4%) CS-MGIT-resistant isolates, which all harbored mutations in the alr gene, including three previously known mutations M343T, T20M, L113R, and a novel mutation R243S, whereas seven low-MIC isolates harboring alr Q30R mutations might not be associated with CS resistance. Notably, M1I, E118K, and A184T in the ald gene and L113R, R243S, S261N, and M343T in the alr gene were predicted to have a destabilizing effect, which could interfere with protein functions and induce drug resistance. …”
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The Effects of Pregnancy and Childbirth on Women's Health-Related Quality of Life: A Scoping Review by Asmaa Othman

“…Although the changes that pregnant women experience are only transitory, they might affect their quality of life. Aim: This scoping review highlight the effect of pregnancy and childbearing on women’s health-related quality of life. …”
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Microcirculatory Disorders in Infant Respiratory Distress Syndrome (Morphological Study) by S. A. Perepelitsa, A. M. Golubev, V. V. Moroz

“…In cases of unfavorable outcomes, dilation of arterial and venous lumen and vascular wall thickening might be considered as principal signs of microcirculatory disorders. …”
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MORALITY, MEDICAL ETHICS AND MEDICAL LAW by P. I. Yatsenko

“…After establishing regulatory frameworks, implementation of health activities ensures the effective implementation of regulatory functions and security law. Moral behavior is the rule, which is common for any society, including the medical. …”
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Synergetic Urban Landscape Planning in Rotterdam by Nico Tillie

“…This renders the assignment more complex but certainly no less landscape architectonic. …”
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Phylogenomic Signatures of a Lineage of Vesicular Stomatitis Indiana Virus Circulating During the 2019–2020 Epidemic in the United States by Selene Zarate, Miranda Bertram, Case Rodgers, Kirsten Reed, Angela Pelzel-McCluskey, Ninnet Gomez-Romero, Luis L. Rodriguez, Christie Mayo, Chad Mire, Sergei L. Kosakovsky Pond, Lauro Velazquez-Salinas

“…Collectively, our study reveals the complex dynamics that accompany the evolution of an epidemic lineage of VSIV in nature. …”
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Altered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure by Haichao Wang, Wen Xue, Jiafen Cheng, Yipei He, Yaxiang Song, Dayong Hu, Ai Peng, Changbin Li, Hui Bao

“…These changes were accompanied by functional alterations in distinctive microbial pathways. …”
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Decoupling working memory impairment from grey matter volume changes in female patients with fibromyalgia: Moderating effect of depression by Ana Belén del Pino, Irene Peláez, Alejandro García-Romero, Maria Luisa Fernández-Sánchez, Paloma Barjola, Vanesa Soto-León, Antonio Oliviero, Francisco Mercado

“…Moderation analyses highlighted the importance of considering affective symptoms of fibromyalgia, such as depression, to characterize associations between local grey matter volumes in the insula and prefrontal cortices (orbitofrontal and ventrolateral prefrontal cortex) with working memory functioning. These results suggest that moderate to severe symptoms of depression appear to be critical for understanding the emergence of associations between grey matter volume and working memory, offering valuable new insights into this complex relationship. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine by Coskun S, Varol S, Ozdemir HH, Agacayak E, Aydın B, Kapan O, camkurt MA, Tunc S, Cevik MU

“…Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. …”
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Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications by Can Qi, Can Qi, Ziwei Zhao, Lin Chen, Le Wang, Yun Zhou, Guochen Duan, Guochen Duan

“…Differential analysis was performed to identify DEGs between subtypes. Functional items and related pathways of DEGs were identified using enrichment analysis. …”
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An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer by Yun Hu, Lanqiao Sun, Jinhua Wang, Yuan Ji, Lili Feng

“…We divided BC patients into lymph node positive and negative groups to identify immune-related lymph node-associated differentially expressed genes (DEGs) for functional enrichment analysis and protein-protein interaction (PPI) network. …”
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Decoration of Mg/Fe layered double hydroxides on coffee waste biochars for enhanced adsorption and selectivity of phosphate ions: Mechanistic studies by Jaegwan Shin, Hojung Rho, Yeonjung Cho, Jinwoo Kwak, Changgil Son, Sangwon Kim, Seohyun Ki, Yong-Gu Lee, Hee-Joong Kim, Sang-Ho Lee, Yongeun Park, Kangmin Chon

“…The variations in the main adsorptive removal mechanisms of PO43- ions by CB from the ligand exchange with alcohol functional groups to the anion exchange with Cl and electrostatic surface complexation with metal contents via the Mg/Fe LDH decoration could significantly improve the selectivity of PO43- ions (decreasing rate of Qe under the co-existing anions: CB = 26.7–98.7 % and MF-L@CB = 1.9–44.2 %). …”
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Edgetic perturbation models of human inherited disorders by Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal

“…Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…However, it is unclear whether and to which extent these events might affect frailty, fastening its development or hampering its reversion. …”
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Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs by Zhen Wang, MD, Mingxiao Li, MD, Peng Xia, BS, Chao Jiang, MD, Ting Shen, MD, Jiaming Ma, MD, Yu Bai, MD, Suhui Zhang, MD, Yiwei Lai, MD, Sitong Li, MS, Hui Xu, MD, Yang Xu, MD, Tong Ma, MS, Lie Ju, PhD, Liu He, PhD, Li Dong, MD, Caihua Sang, MD, Deyong Long, MD, Yuzhong Chen, PhD, Xin Du, MD, Zongyuan Ge, PhD, Jianzeng Dong, MD, Wen-Bin Wei, MD, Changsheng Ma, MD

“…Conclusion: A vision-ensemble model based on fundus images might be practical for preliminary screening of CI in AF patients.…”
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