Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation by Tessa Nelemans, Ali Tas, Nina L. de Beijer, George M. C. Janssen, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert

“…P62 thus plays an antiviral role during USUV infection, although this antiviral effect might also be related to its functions outside the autophagy pathway, such as modulation of the immune response. …”
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Identification and validation of oxidative stress-related genes for the diagnosis of sepsis-induced acute lung injury. by Xue Fu, Jiawei Dong, Jian Yang, Xiaotian Zhang, Sen Wang, Shangkun Cai, Yiwei Zhang, Meng Zhang

“…Sepsis-induced acute lung injury (ALI) is an inflammatory pulmonary condition characterized by a complex pathophysiological mechanism. The development and progression of sepsis-induced ALI are accompanied by significant oxidative damage. …”
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Analysis of Flow-induced Vibration Characteristics of Fuel Rods Using POD and DMD Methods by MIN Guangyun1, JIANG Naibin1, 2

“…To unravel the intricacies of this complex phenomenon, a sophisticated high-fidelity finite element model of fuel rods was meticulously constructed. …”
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Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…To maintain synchronization in power systems, frequency must remain constant; disruptions in the proper balance of production and load might produce frequency variations, risking serious issues. …”
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Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Abstract Background Targeting lung cancer while sparing healthy cells is the cornerstone of chemotherapy; however, bioavailability issues and complex biological barriers prevent their accumulation in the tumor sites. …”
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miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells by Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng

“…Surprisingly, the mRNA levels of most previously reported miR-210 target genes were not induced upon miR-210 KO, suggesting a need to reexamining and studying human miR-210 functions directly and comprehensively. Thus, our work established a human cellular system and opportunity to unravel the complexity of the regulatory networks by miR-210.…”
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PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy by Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera

“…Overall, the data suggest that PPARβ/δ agonists might be useful in preventing inflammation and fibrosis progression in DCM.…”
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Addressing the need for non-invasive lung assessment with time-resolved diffuse optics by Giulia Maffeis, Nicola Serra, Alessandro Bossi, Alessandro Bossi, Elisabetta Avanzi, Alberto Dalla Mora, Laura Di Sieno, Rinaldo Cubeddu, Antonio Pifferi, Antonio Pifferi, Paola Taroni, Paola Taroni

“…Photons in the 600–1,300 nm range might have the potential to reach lungs and provide compositional and functional information. …”
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Identification of biomarkers and target drugs for melanoma: a topological and deep learning approach by Xiwei Cui, Xiwei Cui, Jipeng Song, Qingfeng Li, Jieyi Ren

“…Advanced network analysis tools were employed to identify structural disparities and functional module shifts. Key driver genes were validated through topological centrality metrics. …”
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The Effect of Transfusion and Hypoxia on Cells in an in vitro Model of the Neurovascular Unit by A. A. Ivkin, E. V. Grigoriev, E. D. Khilazheva, A. V. Morgun

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Inertial-Based Dual-Task Gait Normalcy Index at Turns: A Potential Novel Gait Biomarker for Early-Stage Parkinson’s Disease by Lin Meng, Xiaofei Zhang, Yu Shi, Xinge Li, Jun Pang, Lei Chen, Xiaodong Zhu, Rui Xu, Dong Ming

“…As one of the main motor indicators of Parkinson’s disease (PD), postural instability and gait disorder (PIGD) might manifest in various but subtle symptoms at early stage resulting in relatively high misdiagnosis rate. …”
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AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway by Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He, Zeyuan Li

“…Methods In this study, we examined adaptor-related protein complex 5 subunit ζ1 (AP5Z1) expression in liver cancer and nearby noncancerous tissues to explore its effects on HCC cell growth, death, and autophagy. …”
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Doing Good Instead of Doing Well? What Lawyers Could be Doing in a World of “Too Many” Lawyers by Carrie Joan Menkel-Meadow

“…The paper explores issues of what constitutes “legal knowledge and expertise” and how such knowledge might be deployed to solve complex social and legal problems outside of conventional legal professional boundaries. …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…Conclusions This study constructed a comprehensive rumen DNA virome profile for Holstein dairy cows, elucidating the structural and functional complexity of rumen viruses, the roles of AMGs, and vOTU-hMAG linkages. …”
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NCBP2 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis by Shichao Li, Yulan Wang, Xi Yang, Miao Li, Guoxiang Li, Qiangqiang Song, Junyu Liu

“…Nevertheless, the precise biological functions and clinical implications of CBC in cancer remain ambiguous, necessitating further investigation for clarification. …”
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Incremental data integration for tracking genotype-disease associations. by Tomasz Konopka, Damian Smedley

“…Incremental integration is thus a suitable framework for tracking functional annotations and linking to complex human pathology.…”
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Three-Dimensional Printing and Its Impact on the Diagnosis and Treatment of Neurodegenerative Disease by Sameer Patil, Ami Thakkar, Ginpreet Kaur, Amisha Vora, Ritu Chauhan, Seema Ramniwas, Abhishek Chauhan, Damandeep Kaur, Hardeep Singh Tuli

“…Neurodegenerative disorders include Alzheimer’s and Parkinson’s, both of which lead to progressive loss of neurons resulting in the severe loss of cognitive and motor functions. These diseases are among the heavy burdens on global healthcare systems largely because there is no cure, and current treatments apply almost entirely to controlling symptoms rather than disease progression. …”
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Microbiological and Physicochemical Approach in the Feeding of Superworm (<i>Zophobas morio</i>) with Petroleum-Derived Polymer Diets by Brandon R. Burgos, Fabiola Morales, Rodrigo Morales-Vera, Cristian Valdés, Jorge Y. Faundez, Eduardo Pereira de Souza, Flavio Henrique-Silva, Ariel D. Arencibia

“…However, recently, some studies have shown that some insects might be able to adapt, consuming a wide range of hydrocarbon base polymers. …”
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Immunoregulatory Effects of <i>Codonopsis pilosula</i> Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice by Yan Long, Hongfei Ji, Jiajing Yang, Haiyu Ji, Keyao Dai, Wenjie Ding, Guoqiang Zheng, Juan Yu

“…This study aimed to investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. …”
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Application of a Hybrid Model Based on CEEMDAN and IMSA in Water Quality Prediction by GUO Li-jin, WU Hao-tian

“…The learning capabilities of different networks for these subsequences were verified, with BiLSTM used to predict high-complexity components, LSSVR for medium-complexity components, and ELM for low-complexity components. …”
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