Identification of Gene Targets for the Sprouting Inhibitor CIPC by Thomas M. Grand, James K. Pitman, Alexander L. Williams, Lisa M. Smith, Andrew J. Fleming

“…This approach led to the identification of a component of the augmin complex (a core player in mitosis) as a potential target for CIPC.…”
Get full text

Dynamic regulation of Rgs16 and its correlation with Neuregulin1 expression in acute and chronic nerve injury by Marina García-Bejarano, Marina García-Bejarano, Marina García-Bejarano, Riccardo Aucello, Riccardo Aucello, Federica Zen, Federica Zen, Marwa El Soury, Marwa El Soury, Francesca Cordero, Jesús M. de la Fuente, Isabelle Perroteau, Giulia Ronchi, Giulia Ronchi, Giovanna Gambarotta, Giovanna Gambarotta

“…Introduction: Regulators of G Protein Signaling (RGS) form a gene family that modulates G protein-coupled receptor signaling by enhancing the GTPase activity of the Gα-GTP complex, effectively inhibiting G protein-dependent signal transduction cascades. …”
Get full text

Inter-reader agreement and additive benefit of SPECT or SPECT/CT modality with [99mTc]Tc-pertechnetate scintigraphy imaging for the assessment of thyroid nodules in a tertiary care... by Emil Novruzov, Dominik Schmitt, Katalin Mattes-György, Julian Kuhlmann, Mareike Muchalla, Matthias Schott, Christina Antke, Frederik L. Giesel, Eduards Mamlins

“…The recent advancements and increasing access of SPECT/CT scanners might contribute to thyroid management. This study aimed to elucidate additive value of SPECT(-CT) imaging in initial evaluation of complex TN cases, particularly on multinodular goiter and difficult-to-characterize solitary nodules. …”
Get full text

Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…Limitations The review was limited by a paucity of theory and economic evaluations, so it is unclear how interventions might function or their potential cost-effectiveness. …”
Get full text

Features of blocking HLA-DR and HLA-G BY the human IgG fraction from the plasma of multiparous women by A. V. Shabaldin, N. S. Deeva, A. S. Sukhikh, G. V. Vavin

Get full text

Solid State Transformers: A Review—Part I: Stages of Conversion and Topologies by Dragoș-Mihail Predescu, Ștefan-George Roșu

“…Converter functionalities are derived based on the number of stages. …”
Get full text

Targeting senescent cells in translational medicine by Marta Paez‐Ribes, Estela González‐Gualda, Gary J Doherty, Daniel Muñoz‐Espín

“…Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. …”
Get full text

The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease by Yu-Long Lan, Shuang Zou, Jian-Jiao Chen, Jie Zhao, Shao Li

“…Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. …”
Get full text

Sport-Orthopädie by Kraus K, Doyscher R, 3, Schütz E

Get full text

Combinations of SNPs related to signal transduction in bipolar disorder. by Pernille Koefoed, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Ingrid Melle, Gert Lykke Møller, Ole Mors, Thomas Werge, Erling Mellerup

“…Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. …”
Get full text

Syntactic development and its interplay with word processing and working memory in preschoolers’ brain: An fNIRS longitudinal study by Dongsu Yan, Tongfu Fang, Wei He, Min Xu

“…We employed functional near-infrared spectroscopy to examine among preschool children (N=50, Mage=61.5 months) the neural activation associated with processing sentences of varying syntactic complexities, as well as tasks assessing word comprehension and working memory. …”
Get full text

Emic and Etic Perspectives on HR Practice for Managing Human Resource Issues Affected by the Prevalence of Informal Networks in Arab Countries by Sa’ad Ali, David Weir, Munirah Sarhan AlQahtani, Mansour Mrabet

“…The findings shed light on the impact of Wasta on HRM practice on the micro and macro levels, highlighting the complex socio-economic needs for this practice which, whilst they might be beneficial on the micro level in terms of securing employment for job seekers and benefits for organizations in the Wasta exchange process, can also have some substantive negative outcomes in the forms of social and economic exclusion of others outside the Wasta network. …”
Get full text

Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets by Nira Hernández-Martín, Ignacio Pozo-Cabanell, Rubén Fernández de la Rosa, Luis García-García, Francisca Gómez-Oliver, Miguel Ángel Pozo, Mirjam Brackhan, Pablo Bascuñana

“…Main body Animal models have proven to be a crucial tool for studying epileptogenesis, many exhibiting cellular, molecular, and functional alterations that resemble those found in human patients. …”
Get full text

Dystonic Movement Disorder as Symptom of Catatonia in Autism Spectrum Disorder by Maria Pia Riccio, Rosamaria Siracusano, Ilaria d’Alessandro, Maria Marino, Carmela Bravaccio

“…Moreover, recognizing symptoms in ASD patients with medium-low functioning might be difficult. Literature on this argument is poor, especially for children. …”
Get full text

Brain Signals of Face Processing as Revealed by Event-Related Potentials by Ela I. Olivares, Jaime Iglesias, Cristina Saavedra, Nelson J. Trujillo-Barreto, Mitchell Valdés-Sosa

“…We analyze the functional significance of different event-related potentials (ERPs) as electrophysiological indices of face perception and face recognition, according to cognitive and neurofunctional models of face processing. …”
Get full text

Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal Stem Cell Recruitment by Julia van de Kamp, Willi Jahnen-Dechent, Bjoern Rath, Ruth Knuechel, Sabine Neuss

“…Due to their high self-renewal capacity and excellent differentiation potential in vitro, MSC are ideally suited for regenerative medicine. The complex interactions of MSC with their environment and their influence on the molecular and functional levels are widely studied but not completely understood. …”
Get full text

A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication by Yaotang Wu, Yang Wu, Chenlu Wang, Ningna Xiong, Wenxin Ji, Mei Fu, Junpeng Zhu, Zhixin Li, Jian Lin, Qian Yang

“…Our findings suggested that virus infection might trigger the upregulation of autophagy and downregulation of the RNAi pathway, revealing a complex interaction between these two biological processes in the defence against viral replication.…”
Get full text

Using the Behaviour Change Wheel to develop an intervention to improve conversations about recovery on the stroke unit. by Louisa-Jane Burton, Anne Forster, Judith Johnson, Thomas F Crocker, David J Clarke

“…This study aimed to begin development of a novel complex intervention to improve conversations about recovery on stroke units.…”
Get full text

Verifiable secure aggregation scheme for privacy protection in federated learning networks by Wujun Yao, Tanping Zhou, Yiliang Han, Xiaolin Wang

“…Most existing solutions assume a semi-honest system, considering each participant to be honest but curious, which does not align with the complex real-world environment. In reality, servers might act maliciously by tampering with or forging aggregation results, which directly threatens the integrity of global models.. …”
Get full text

L’activité réflexive des agents de terrain lors d’un dispositif de formation hybride qui intègre de la réalité virtuelle by Artémis Drakos, Jacques Theureau, Geneviève Filippi, Simon Flandin, Germain Poizat

“…Designed by the researchers and a trainer, this device, known as scenario-inquiry, is intended to help trainees gain an understanding of the spatial and functional characteristics of a complex industrial building, essential knowledge for their future job as field operators. …”
Get full text