Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Conclusions These findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo +/+ inherit identical genetic material as WT-Control, their development might be shaped by the parent’s physiology, behavior, or metabolic state influenced by their Kmo genotype, leading to phenotypic sex-specific differences in offspring.…”
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Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats by Andreas V. Madsen, Peter Kristensen, Alexander K. Buell, Steffen Goletz

“…We find that N-terminal sdAb fusion might sterically hinder antigen-binding to the Fv region of the IgG scaffold, whereas C-terminal fusion might disturb antigen-binding to the fused sdAb. …”
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Case report: Clinical and genetic characteristics of heterozygous CaSR variants in three Chinese females with familial hypocalciuric hypercalcemia type 1: a report of three cases by Ruxuan Zhang, Ruxuan Zhang, Tingting Hu, Shuai Wang, Yiping Cheng, Dandan Luo, Dongmei Zheng, Xinli Zhou, Xinli Zhou, Xinli Zhou

“…The analysis of the conservation of homologous species and the prediction of protein structure for all variant sites demonstrated that due to the heterozygous variants in CaSR, relatively conserved amino acids were altered, affecting the interaction forces between adjacent amino acids, resulting in changes in the protein structure, which might affect the function of the protein.ConclusionIn conclusion, we report three cases of FHH1 with different heterozygous variant sites in the CaSR gene. …”
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Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development by Chao Yang, Lingxi Zhu, Li Tang, Xiangyu Zhang, Min Lei, Xiaohong Xie, Cuixia Zhang, Dingsheng Yuan, Congyan Li, Ming Zhang

“…GO (Gene Ontology) analysis of DEGs indicated DEGs in the thigh muscle were enriched in these terms related to biological processes of muscle cell migration and smooth muscle cell migration, cellular components of sarcomere, myofibril, and actin filament bundle, while DEGs in <i>longissimus dorsi</i> muscle were enriched in these terms associated with biological processes of muscle cell migration, smooth muscle cell migration and muscle structure development, cellular component of actin cytoskeleton, contractile fiber, myofibril, myosin complex and molecular function of actin filament binding. …”
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Screening and Analysis of Proteins Interacting with TaPDK from Physiological Male Sterility Induced by CHA in Wheat by Long-yu ZHANG, Gai-sheng ZHANG, Xin-liang ZHAO, Shu-ling YANG

“…Collectively, these datas indicated that the majority of candidate proteins might be related to pollen abortion in PHYMS lines, which further suggested that TaPDK plays multiple roles in pollen development, besides participating in regulating pyruvate dehydrogenase complex activity.…”
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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…Abstract Background Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. …”
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Developing approaches to treating arterial hypertension in regard to possible pathways of angiotensin II synthesis by N. M. Chikhladze, N. V. Lebedeva, L. A. Belova, G. N. Litonova, E. B. Yarovaya, I. E. Chazova

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Clinical manifestations of dual-gene variants involving ABCA4 in retinal dystrophies by Lasse Wolfram, David A. Merle, Laura Kühlewein, Milda Reith, Melanie Kempf, Krunoslav Stingl, Tobias Haack, Pascale Mazzola, Karin Poths, Nicole Weisschuh, Bernd Wissinger, Susanne Kohl, Katarina Stingl

“…Conclusions This study underscores the importance of advanced diagnostic tools and careful genotype evaluation to accurately identify and understand potential complex genetic interactions in IRDs. The observed phenotypes enhance our understanding of how these genes contribute to human retinal function and dysfunction. …”
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Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies by M. Sicorello, J. Herzog, T.D. Wager, G. Ende, M. Müller-Engelmann, S.C. Herpertz, M. Bohus, C. Schmahl, C. Paret, I. Niedtfeld

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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…These findings demonstrate that peroxisomal impairments in microglia exacerbate inflammatory response and ROS/NO production, affecting the survival of neurons and oligodendrocytes, as well as neuronal morphology and function. This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. …”
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Research progress of chondroitin sulfate and chondroitin sulfate proteoglycan in diabetic kidney disease by ZHANG Min, HU Chun, WU Xiao-yan

“…Chondroitin sulfate/chondroitin sulfate proteoglycan(CS/CSPG) is an essential component of ECM, including a large family of biological active molecules with complex structures and various functions. They play important functional and regulatory roles in physiology and pathology. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
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Unraveling the source of corrosive microorganisms from fracturing water to flowback water in shale gas field: evidence from gene sequencing and corrosion tests by Yanran Wang, Shaomu Wen, Shibo Zhang, Yongfan Tang, Xi Yuan, Fang Guan, Fang Guan, Jizhou Duan

“…As an insidious and often underestimated phenomenon, microbially influenced corrosion (MIC) poses a significant threat to the integrity and longevity of oil and gas pipelines. However, the complex corrosive microorganisms, that might induce MIC in underground pipelines, might be introduced by the fracturing water during the production period, or they may also exist in the native corrosive microbial community underground. …”
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Step-by-step: Intra-arterial renal hypothermia during robot-assisted partial nephrectomy by Joris Vangeneugden, Pieter De Backer, Camille Berquin, Saar Vermijs, Peter Dekuyper, Alexandre Mottrie, Charlotte Debbaut, Thierry Quackels, Charles Van Praet, Karel Decaestecker

“…Objective: Renal hypothermia, which can be achieved through several techniques, might allow for longer clamping times in complex robot-assisted partial nephrectomy (RAPN). …”
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On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa by Corinna Benz, Maximilian W. D. Raas, Pragya Tripathi, Drahomíra Faktorová, Eelco C. Tromer, Bungo Akiyoshi, Julius Lukeš

“…Here, we employed deep homology detection protocols using profile-versus-profile Hidden Markov Model searches and AlphaFold-based structural comparisons to detect homologies that might have been previously missed. Interestingly, we still could not detect orthologs for most of the kinetoplastid or canonical kinetochore subunits with few exceptions including a putative centromere-specific histone H3 variant (cenH3/CENP-A), the spindle checkpoint protein Mad2, the chromosomal passenger complex members Aurora and INCENP, and broadly conserved proteins like CLK kinase and the meiotic synaptonemal complex proteins SYCP2/3 that also function at kinetoplastid kinetochores. …”
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Presidential elections of 1997: a comparative analysis of electoral provisions and stereotypes by Lauras Bielinis

“…That is why very often in the world of political evaluations, clear and correct functional relations between the cause and the outcome do not exist. …”
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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis

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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology by Ki‐Kwang Oh, Sang‐Jun Yoon, Sang Youn Lee, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Tae Suk

“…Abstract Cornus kousa fruit (CKF) has been utilized as anti‐obesity supplementation in East Asia, including Korea, and gut microbiota (GM) might have synergistic effects on obesity (OB) via its interplay. …”
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Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in an Ex vivo skin model by Giulia Zivelonghi, Luca Melotti, Anna Carolo, Andrea Venerando, Margherita Roncoroni, Giordana Martinelli, Lisa Maccatrozzo, Stefania Marzorati, Michela Sugni, Marco Patruno

“…IntroductionThe skin is often exposed to harmful stimuli that might compromise its integrity and functionality. …”
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Novel potential biomarkers for predicting childhood caries via metagenomic analysis by Hui Zhang, Hui Zhang, Xiao Zheng, Xiao Zheng, Xiao Zheng, Yongmao Huang, Yongmao Huang, Yuanqiang Zou, Tao Zhang, Maria Alice Repo, Maria Alice Repo, Meixiang Yin, Yang You, Zhuye Jie, Wen-an Xu, Wen-an Xu

“…Additionally, we identified 16 species as the best marker for severe dental caries, achieving an impressive AUC of 0.91.ConclusionThe role of microbiota in dental caries is multifaceted, involving a complex interplay of microbial species and functions. …”
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