Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia by Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer

“…We propose that CSF SNAP-25 level might represent an integrated readout of reduced synaptic function, rather than of synaptic degeneration, in MDD. …”
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Exercise in atherosclerosis: its beneficial effects and underlying mechanism by Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Liang Guo, Liang Guo, Liang Guo, Liang Guo

“…Fully understanding the effects and mechanisms of exercise in reducing atherosclerosis might open doors to developing safe and effective interventions.…”
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The double role of GABAergic system in systemic tumors: an updated review by Xueyang Yang, Qianhe Zu, Luxuan Wang, Chunhui Li, Lijian Zhang, Lijian Zhang

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A cell cycle timer for asymmetric spindle positioning. by Erin K McCarthy Campbell, Adam D Werts, Bob Goldstein

“…We found that reducing the function of the proteasome, the APC, or Cdc20/Fizzy delayed spindle displacement. …”
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Rett Syndrome: From Bed to Bench by Shih-Ming Weng, Mark E.S. Bailey, Stuart R. Cobb

“…As shown in human studies, Mecp2 mutants also display subtle alterations in neuronal morphology, including smaller cortical neurons with a higher-packing density and reduced dendritic complexity. Neurophysiological studies in Mecp2-mutant mice consistently report alterations in synaptic function, notably, defects in synaptic plasticity. …”
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Combination of the ranking method and time reversal asymmetry for evaluating the quality of translations: a case study on passages from works by Edgar Allan Poe and Kenzaburo Oe by Kazuya Hayata

“…The complex systems approach to natural language has become a fascinating topic that is closely related to physics and linguistics. …”
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The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Autophagy, an evolutionarily preserved cellular mechanism for degradation and recycling, has a complex function in cancer by aiding cell survival during stress and preserving balance by eliminating damaged organelles and proteins. …”
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Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports by Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang

“…By disrupting histone-DNA contacts, this complex modulates gene expression patterns, and accumulating evidence suggests its tumor suppressor function. …”
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Membranoproliferative Glomerulonephritis and X-Linked Agammaglobulinemia: An Uncommon Association by Vasco Lavrador, Filipa Correia, Rita Sampaio, Cristina Cândido, Maria Sameiro-Faria, Laura Marques, Conceição Mota

“…He presented with pneumonia, macroscopic hematuria, nephrotic proteinuria, hypoalbuminemia, and hypercholesterolemia with normal renal function and serum complement levels. Renal histology showed immune complex mediated MPGN. …”
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Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions by Gianmarco Gualtieri, Emanuele Liborio Citriniti, Roberta Rocca, Valentina Arciuolo, Jussara Amato, Antonio Randazzo, Stefano Alcaro

“…Modulating their stability and function holds promise for treating diseases like cancer. …”
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Exploring Basic Psychological Need Satisfaction and Relationship Quality as Protective Factors of Mental Well-Being During the COVID-19 Pandemic by Barbara Horvát, Tamás Martos, Claudia Chiarolanza, Viola Sallay, Ashley K. Randall

“…While better relationship experiences might even heighten perceived stress during a global crisis, they simultaneously function as protective factors for overall mental health.…”
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The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop by D. Pagliari, R. Urgesi, S. Frosali, M. E. Riccioni, E. E. Newton, R. Landolfi, F. Pandolfi, R. Cianci

“…Dysfunction of the innate and adaptive immune systems can conceivably cause impairment of mucosal barrier function and development of localized or systemic inflammatory and autoimmune processes. …”
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Comparative analyses of the gut microbiome of two sympatric rodent species, Myodes rufocanus and Apodemus peninsulae, in northeast China based on metagenome sequencing by Jing Cao, Shengze Wang, Ruobing Ding, Yijia Liu, Baodong Yuan

“…The gut microbiota of A. peninsulae and M. rufocanus differed marginally in functional profiles, specifically in the breakdown of complex carbohydrates, which might reflect their distinct food preferences albeit both being herbivores with a substantial dietary overlap. …”
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A neural circuit covarying with social hierarchy in macaques. by MaryAnn P Noonan, Jerome Sallet, Rogier B Mars, Franz X Neubert, Jill X O'Reilly, Jesper L Andersson, Anna S Mitchell, Andrew H Bell, Karla L Miller, Matthew F S Rushworth

“…To examine this possibility we used magnetic resonance imaging (MRI), which affords the taking of quantitative measurements noninvasively, both of brain structure and of brain function, across many regions simultaneously. We carried out a series of tests of structural and functional MRI (fMRI) data in 25 group-living macaques. …”
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Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions. by Pornchai Anuntasomboon, Suradej Siripattanapipong, Sasimanas Unajak, Kiattawee Choowongkomon, Richard Burchmore, Saovanee Leelayoova, Mathirut Mungthin, Teerasak E-Kobon

“…The intricate interplay between SNPs and gene expression alterations might underscore the complex regulatory networks underlying the AmB resistance of L. orientalis strain PCM2.…”
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Resolving structural variability in network models and the brain. by Florian Klimm, Danielle S Bassett, Jean M Carlson, Peter J Mucha

“…Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. …”
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Lightweight deep learning system for automated bone age assessment in Chinese children: enhancing clinical efficiency and diagnostic accuracy by Pang Hai, Zhang Bin, Liu Kesheng, Li Cong, Xu Fei

“…This lightweight design reduces computational complexity, enabling faster inference while maintaining diagnostic precision. …”
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ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics. by Jamie S Lin, Jin Seok Jeon, Qingfeng Fan, Hetty N Wong, Matthew B Palmer, Lawrence B Holzman

“…In several cellular systems, ARF6 was shown to regulate actin dynamics in coordination with Rac1, a Rho small GTPase. We examined the function of ARF6 in the kidney podocyte because Rac1 was implicated in kidney diseases involving this cell. …”
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Military experience predicts military multitasking better than laboratory measures in officer cadets by Yannik Hilla, Maximilian Stefani, Elisabeth V. C. Friedrich, Wolfgang Mack

“…We discuss the role of learned task representations in this regard and conclude that it might be more reasonable to investigate cognitive functions as co-variates of associations between military characteristics (e.g., military service duration) and military performance in future research than to focus on laboratory measures as predictors of military performance.…”
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Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells. by Xiaoting Fan, Qian Zhang, Chao You, Yuanxia Qian, Jing Gao, Peng Liu, Huiqing Chen, Huifang Song, Yan Chen, Keping Chen, Yajing Zhou

“…In vitro pull down and co-immunoprecipitation assays show that the μ-calpain binds to p12 through the interaction of μ-calpain with Pol δ other three subunits, not p12 itself, and PCNA, implying that the proteolysis of p12 by μ-calpain might be through a Pol δ4/PCNA complex. The p12 cleavage sites by μ-calpain are further determined as the location within a 16-amino acids peptide 28-43 by in vitro cleavage assays. …”
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