Identification of Potential Inhibitors Targeting Non-Structural Proteins NS3 and NS5 of Dengue Virus Using Docking and Deep Learning Approaches by Alomgir Hossain, Faria Tasnin Joti, Md. Shohag Hossain, Abdullah Al-Noman, Chomong Thowing, Mehjabin Mursona, Md. Robiul Islam, Md. Ekhtiar Rahman, Mohammad Nurul Matin, Md Azizul Haque

“…Our identified new drug candidates might help for developing effective antiviral inhibitors against the DENV. …”
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Deciphering algorithmic collusion: Insights from bandit algorithms and implications for antitrust enforcement by Frédéric Marty, Thierry Warin

“…Legally, the primary challenge lies in detecting and categorizing possible algorithmic signals, particularly when they function as unilateral communications. Economically, the task of distinguishing between rational pricing strategies and collusive patterns becomes increasingly complex in the context of algorithm-driven decisions. …”
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Alzheimer's Disease: Another Target for Heparin Therapy by Luigi Bergamaschini, Emanuela Rossi, Carlo Vergani, Maria Grazia De Simoni

“…The complexity of AD pathology provides numerous potential targets for therapeutic interventions. …”
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Pills, Power and Performativity: Negotiating Masculinity in the Emergence of Male Contraceptive Technology by Eleonore Lorijn

“…Specifically, I seek to understand how contraceptive technology might contribute to the emergence and transformation of different masculine identities, and whether these identities will function to enhance or denounce the technology's cultural feasibility and widespread assimilation. …”
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Anesthetic challenges in a cardiac patient undergoing noncardiac surgery by Vaishali S Badge, Pankaj Patil

“…The case was done on an urgent basis thinking that the patient might lose eyesight if he is not operated quickly. …”
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Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2 by Chennu Manisha, Nagarjuna Palathoti, Jagdish Chand, Akey Krishna Swaroop, Jubie Selvaraj, B.R. Prashantha Kumar, Prisil Naveentha X, Brindha Durairaj, Antony Justin

“…Therefore, compounds that enhance EAAT2 function by reducing oxidative stress and excitotoxicity might be neuroprotective. …”
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Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis by Jonás Carmona-Pírez, Rocío Salsoso, Eléna Charpentier, Cinta Olmedo, Francisco J. Medrano, Lucas Román, Carmen de la Horra, Yaxsier de Armas, Enrique J. Calderón, Vicente Friaza

“…We found 11 protein complexes, notably the JAK-STAT signaling complex in non-colonized IPF patients. …”
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Endocrine consequences of childhood obesity: a narrative review by Maroun Badr, Ghazwa El-Rabaa, Marianne Freiha, Andrzej Kędzia, Elżbieta Niechciał

“…If insulin resistance is not adequately managed, it might precipitate type 2 diabetes. Another common finding among children with obesity is thyroid dysfunction. …”
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What Lies Inside a Dead Coral: Diversity of Reef-Associated Cryptic Crustacean (Crabs: Anomura and Brachyura) from Different Habitat Characteristics in Tidung Islands, Indonesia by Satya Pratama Atmaja, Prakas Santoso, Muhamad Gilang Arindra Putra, Fadel Muhammad, Wiwid Andriyani Lestariningsih, Beginer Subhan, Hawis Madduppa

“… • Different characteristics and complexity of coral habitat affect the dynamics of cryptic crustacean communities   Abstract   Recent studies have been widely carried out on the important role and ecological function of coral reefs. …”
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Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis by Fereshteh Ahmadinejad, Seyed Javad Mowla, Mohammad-Amin Honardoost, Mostafa Gholami Arjenaki, Mohammad Moazeni-Bistgani, Soleyman Kheiri, Hossein Teimori

“…These findings suggest that miR-218 expression profiling might be clinically applicable as a prognostic biomarker in breast cancer. …”
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Integrating proteomic and phosphoproteomic profiles provide new insights into ABA-dependent signal regulation network in maize response to heat stress by Yanpei Liu, Yulong Zhao, Haiying Zhan, Shanshan Lv, Yanmin Luo, Wei Wang, Xiuli Hu

“…Among them, heat shock proteins (17 DEPs and 3 DEPPs), transcription factors (9 DEPs and 27 DEPPs), ubiquitin-proteasome system components (1 DEP and 6 DEPPs), translation-related to proteins (23 DEPs and 22 DEPPs) and defensive proteins (12 DEP and 24 DEPPs) were identified, indicating that chaperon protein function, protein turnover, and defense system might be the key ABA-mediated processes in maize HS response. …”
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C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages by Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li

“…Our article found C5aR2 deficiency lessened C5aR1 distribution and expression in neutrophils and macrophages with different functions, indicating C5aR2 might function differently in different cells.…”
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The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review by Siobhan C. Murray, Claire McNamara, Anna V. Chatzi

“…As clinicians' ethical considerations and fears emerged from the literature, nurses' special role has not been sufficiently supported. Complex care requires facilitation by multidisciplinary teams and education around the device's function regarding EOL issues. …”
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On the Analysis of the Contact Conditions in Temporomandibular Joint Prostheses by B. Gonzalez-Perez-Somarriba, G. Centeno, C. Vallellano, L. M. Gonzalez-Perez

“…Although temporomandibular joint replacements (TMJRs) are expected to accomplish their function during a number of years, they might actually fail and need to be replaced. …”
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Model order reduction for left ventricular mechanics via congruency training. by Paolo Di Achille, Jaimit Parikh, Svyatoslav Khamzin, Olga Solovyova, James Kozloski, Viatcheslav Gurev

“…While finite element models of the heart can naturally account for patient-specific anatomies reconstructed from medical images, optimizing the many other parameters driving simulated cardiac functions is challenging due to computational complexity. …”
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Monocephalus dipygus in a 4-month-old mixed-breed puppy: clinical, radiographic, ultrasonographic, karyotyping and surgical intervention by Lorena Elizabeth Chalco-Torres, Ana Elizabeth Guerrero López, Mauro Nirchio Tursellino

“…Notably, since each bladder was independently connected to a kidney, surgical intervention in the genitourinary system was avoided to prevent potential impairment of urinary function. This case highlights the complexity of congenital anomalies in canines and emphasizes the importance of a multidisciplinary approach to their diagnosis and management.…”
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Novel Approaches to Ileocolic and Perianal Fistulising Crohn’s Disease by Gaetano Luglio, Gianluca Cassese, Alfonso Amendola, Antonio Rispo, Francesco Maione, Giovanni Domenico De Palma

“…Nowadays, the introduction of both laparoscopy and novel surgical techniques, the improvement of recovery pathways, and the opening of new frontiers are allowing healthcare professionals to deal with complex and recurrent scenarios, trying to spare bowel and anal function, thus ensuring a better quality of life for the patient. …”
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Bacterial wilt resistance gene Slmlo1/6 mutants in tomato created by CRISPR/Cas9 technology by SHI Jianlei1, 2, XIONG Zili1, SU Shiwen1, FU Cunnian1, ZAI Wenshan1*

“…The pathogenic species are complex and tend to have a variation, while mlo caused by the recessive mutation of MLO genes has a broad-spectrum resistance. …”
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A Norwegian cohort with STAT1-related disease – further expanding the clinical phenotype by Karen Helene Bronken Martinsen, Karen Helene Bronken Martinsen, Torstein Øverland, Asbjørg Stray-Pedersen, Tore G. Abrahamsen, Børre Fevang, Børre Fevang, Hans Christian Erichsen Landsverk, Hans Christian Erichsen Landsverk

“…Presently, our cohort represents the largest nationwide study on STAT1-related disease.ConclusionWe report novel clinical manifestations in STAT1 GOF, and suggest that heterozygous STAT1 LOF might be a more complex condition than originally presumed.…”
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VPS35-Retromer: Multifunctional Roles in Various Biological Processes &ndash; A Focus on Neurodegenerative Diseases and Cancer by Fan X, Xie Y, Cao S, Zhu L, Wang X

“…As an integral component of the Retromer complex, VPS35 selectively recognizes and retrogradely transports membrane protein receptors to the trans-Golgi network, thereby preventing the degradation of transmembrane proteins by lysosomes after they have fulfilled their physiological functions, and facilitating their continued activity. …”
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