Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration by Kimberly Hernandez, Caitlin H Nguyen, Girdhari Rijal

“…Complexities in cell-cell and cell-matrix interactions, and different in types and ratios of ECM proteins in a TME challenge to reveal the precise function of a particular protein that is exhibited by special cells and if specifically present in insignificant amount. …”
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Magnetite particle size and spatial distribution may modulate neural oscillation in the human brain by Gunther Kletetschka, Robert Bazala

“…Magnetite, a naturally occurring magnetic material found in brain tissue, has been the subject of increasing scientific interest due to its potential role in brain function and its possible link to neurodegenerative diseases. …”
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Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis by Liang Zhao, Hongling Jia, Zhikai Xiahou, Li Ren, Yanbing Song, Hao Xu, Zhihan Wang, Jin Xing

“…We found that ECs might play a role in MEN progression and further classified them into four subpopulations. …”
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Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface by Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco

“…Results: Simulations report poor affinity of CD2v to CD58 in the "canonical" pose and present a novel pose backed by docking, simulation data, and recent observations. The new site might have developed due to immunological considerations and may reproduce observed lymphocyte non-proliferation by hijacking CD58-CD2 ruler functions in immunological synapse formation. …”
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Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis by Robert Gross, Jennifer Davis, Julie Roth, Henry Querfurth

“…We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. …”
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Transition metal abundance as a key parameter for the search of Life in the Universe by Giovanni Covone, Donato Giovannelli

“…The availability of these transition metals is not uniform in the Universe, and it is a function of the distribution (in time and space) of complex dynamics. …”
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Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-anal... by Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun, Zhong Wang

“…GBM multi-omics data from public and in-house cohorts validated that CD44 and SURF4 might be synthetic lethal partners of loss-of-function tumor suppressor genes. …”
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A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10. by Jacopo Lucchetti, Marianna Marino, Simonetta Papa, Massimo Tortarolo, Giovanna Guiso, Silvia Pozzi, Valentina Bonetto, Silvio Caccia, Ettore Beghi, Caterina Bendotti, Marco Gobbi

“…Recently, the coenzyme-Q (CoQ) complex, a key component of mitochondrial function and redox-state modulator, has raised interest for ALS treatment. …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Background For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. …”
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Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis by Yinyi Xiong, Li Li, Xiaorong Zhang

“…In contrast, it is capable of mediating multifaced neurological functions which are more complex than those of Drosophila Dscam. …”
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Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder by Weipu Mao, Tracy Zhang, Huan Chen, Sagar Barge, Zongwei Wang, Aria Olumi, Seth Alper, Weiqun Yu

“…The urothelial-localized ACVR2B/ACVR1B receptor complex suggests a role of activin signaling in urothelial function. …”
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EgoCor: An R Package to Facilitate the Use of Exponential Semi-Variograms for Modelling the Local Spatial Correlation Structure in Social Epidemiology by Julia Dyck, Jan-Ole Koslik, Odile Sauzet

“…Existing tools for the analysis of spatial data in R might appear too complex to non-specialists which could limit the use of the approach. …”
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Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism by Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li

“…These results suggest that chronic oral SFN-I protects against DCM by mitigating overall metabolic dysregulation and inhibiting cardiolipotoxicity. The latter might involve controlling cardiac fatty acid metabolism and improving mitochondrial function, rather than promoting glucose metabolism.…”
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Unconventional T Cells’ Role in Cancer: Unlocking Their Hidden Potential to Guide Tumor Immunity and Therapy by Paola Pinco, Federica Facciotti

“…The complex crosstalk between UC T cells and the surrounding factors is discussed in this review, with a focus on how these cells might be interesting candidates to explore and exploit as anticancer therapeutic agents. …”
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Solar Biota. Co-Living with Solar Ecologies by Suzanna Törnroth

“…The central question to this study is thus – How might a relational adoption of solar PVs increase multispecies flourishing? …”
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How Much Rationality Is Needed for Decision Making? by Annette Grathoff

“…With the perspective that the evolution of information processing systems is already beginning in a physical and chemical pre-biotic world, this is an interesting case that might give further insight into how and when choices between many possibilities could threaten the function of a system rather than making it more durable and adaptable. …”
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Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis by Ran Guo, Hao Wang, Na Cui

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Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. by Enrica San Pietro, Mariagrazia Capestrano, Elena V Polishchuk, Alessio DiPentima, Alvar Trucco, Pasquale Zizza, Stefania Mariggiò, Teodoro Pulvirenti, Michele Sallese, Stefano Tete, Alexander A Mironov, Christina C Leslie, Daniela Corda, Alberto Luini, Roman S Polishchuk

“…Here, we examine the mechanisms of generation and the function of these tubules. In principle, tubule formation might depend on several protein- and/or lipid-based mechanisms. …”
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Breast cancer in young patients. Peculiarities of prognosis and adjuvant hormone therapy (a literature review) by D. N. Kravchenko, A. A. Parokonnaya, M. I. Nechushkin, E. A. Nikitina, N. D. Hakurinova

“…Gradually are being collected data according to what age might be an independent factor exacerbating prognosis. …”
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Relationship between reduced serum ceruloplasmin levels and executive dysfunction in hospitalized schizophrenia patients by Dan Kuang, Hongkai Wei, Wei Qin

“…ObjectiveExecutive dysfunction is a widespread and complex manifestation in schizophrenia, significantly impairing patients’ cognitive and functional outcomes. …”
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