Transition metal abundance as a key parameter for the search of Life in the Universe by Giovanni Covone, Donato Giovannelli

“…The availability of these transition metals is not uniform in the Universe, and it is a function of the distribution (in time and space) of complex dynamics. …”
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VPS35-Retromer: Multifunctional Roles in Various Biological Processes – A Focus on Neurodegenerative Diseases and Cancer by Fan X, Xie Y, Cao S, Zhu L, Wang X

“…As an integral component of the Retromer complex, VPS35 selectively recognizes and retrogradely transports membrane protein receptors to the trans-Golgi network, thereby preventing the degradation of transmembrane proteins by lysosomes after they have fulfilled their physiological functions, and facilitating their continued activity. …”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

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Exercise: a non-drug strategy of NK cell activation by Huixin Pan, Rui Meng, Zixuan Jia, Jing Zhang, Wen Ma, Youhan Liu, Qinglu Wang, Qiaoqiao Li

“…So far, it is widely believed that moderate exercise can significantly enhance the proliferation and activity of NK cells, strengthening immune function. However, the impact of exercise on NK cells is a dynamic and complex process. …”
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Relationship between reduced serum ceruloplasmin levels and executive dysfunction in hospitalized schizophrenia patients by Dan Kuang, Hongkai Wei, Wei Qin

“…ObjectiveExecutive dysfunction is a widespread and complex manifestation in schizophrenia, significantly impairing patients’ cognitive and functional outcomes. …”
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TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. by Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

“…Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. …”
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Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. by Thomas J Carney, Natália Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M Gebauer, Jared Coffin Talbot, Charles B Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W Ingham, Matthias Hammerschmidt

“…In addition, the novel genes might prove helpful to unravel the molecular nature of thus far unresolved cases of the human disease.…”
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Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. by Jennifer H Stuart, Rebecca P Sumner, Yongxu Lu, Joseph S Snowden, Geoffrey L Smith

“…Here we show that vaccinia virus (VACV) strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation, thereby restricting type I IFN production from infected cells. …”
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Magnetite particle size and spatial distribution may modulate neural oscillation in the human brain by Gunther Kletetschka, Robert Bazala

“…Magnetite, a naturally occurring magnetic material found in brain tissue, has been the subject of increasing scientific interest due to its potential role in brain function and its possible link to neurodegenerative diseases. …”
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The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Autophagy, an evolutionarily preserved cellular mechanism for degradation and recycling, has a complex function in cancer by aiding cell survival during stress and preserving balance by eliminating damaged organelles and proteins. …”
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Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports by Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang

“…By disrupting histone-DNA contacts, this complex modulates gene expression patterns, and accumulating evidence suggests its tumor suppressor function. …”
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Unconventional T Cells’ Role in Cancer: Unlocking Their Hidden Potential to Guide Tumor Immunity and Therapy by Paola Pinco, Federica Facciotti

“…The complex crosstalk between UC T cells and the surrounding factors is discussed in this review, with a focus on how these cells might be interesting candidates to explore and exploit as anticancer therapeutic agents. …”
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How Much Rationality Is Needed for Decision Making? by Annette Grathoff

“…With the perspective that the evolution of information processing systems is already beginning in a physical and chemical pre-biotic world, this is an interesting case that might give further insight into how and when choices between many possibilities could threaten the function of a system rather than making it more durable and adaptable. …”
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EgoCor: An R Package to Facilitate the Use of Exponential Semi-Variograms for Modelling the Local Spatial Correlation Structure in Social Epidemiology by Julia Dyck, Jan-Ole Koslik, Odile Sauzet

“…Existing tools for the analysis of spatial data in R might appear too complex to non-specialists which could limit the use of the approach. …”
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A Norwegian cohort with STAT1-related disease – further expanding the clinical phenotype by Karen Helene Bronken Martinsen, Karen Helene Bronken Martinsen, Torstein Øverland, Asbjørg Stray-Pedersen, Tore G. Abrahamsen, Børre Fevang, Børre Fevang, Hans Christian Erichsen Landsverk, Hans Christian Erichsen Landsverk

“…Presently, our cohort represents the largest nationwide study on STAT1-related disease.ConclusionWe report novel clinical manifestations in STAT1 GOF, and suggest that heterozygous STAT1 LOF might be a more complex condition than originally presumed.…”
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The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. by Anna Ghelli, Anna Maria Porcelli, Claudia Zanna, Sara Vidoni, Stefano Mattioli, Anna Barbieri, Luisa Iommarini, Maria Pala, Alessandro Achilli, Antonio Torroni, Michela Rugolo, Valerio Carelli

“…Recently it was also documented that the professional exposure to n-hexane might act as an exogenous trigger for LHON. Therefore, we here investigate the effect of the n-hexane neurotoxic metabolite 2,5-hexanedione (2,5-HD) on cell viability and mitochondrial function of different cell models (cybrids and fibroblasts) carrying the LHON mutations on different mtDNA haplogroups. …”
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Pills, Power and Performativity: Negotiating Masculinity in the Emergence of Male Contraceptive Technology by Eleonore Lorijn

“…Specifically, I seek to understand how contraceptive technology might contribute to the emergence and transformation of different masculine identities, and whether these identities will function to enhance or denounce the technology's cultural feasibility and widespread assimilation. …”
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Deciphering algorithmic collusion: Insights from bandit algorithms and implications for antitrust enforcement by Frédéric Marty, Thierry Warin

“…Legally, the primary challenge lies in detecting and categorizing possible algorithmic signals, particularly when they function as unilateral communications. Economically, the task of distinguishing between rational pricing strategies and collusive patterns becomes increasingly complex in the context of algorithm-driven decisions. …”
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Anesthetic challenges in a cardiac patient undergoing noncardiac surgery by Vaishali S Badge, Pankaj Patil

“…The case was done on an urgent basis thinking that the patient might lose eyesight if he is not operated quickly. …”
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A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10. by Jacopo Lucchetti, Marianna Marino, Simonetta Papa, Massimo Tortarolo, Giovanna Guiso, Silvia Pozzi, Valentina Bonetto, Silvio Caccia, Ettore Beghi, Caterina Bendotti, Marco Gobbi

“…Recently, the coenzyme-Q (CoQ) complex, a key component of mitochondrial function and redox-state modulator, has raised interest for ALS treatment. …”
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