Biological pathways leading to septo-optic dysplasia: a review by Ludovica Pasca, Davide Politano, Federica Morelli, Jessica Garau, Sabrina Signorini, Enza Maria Valente, Renato Borgatti, Romina Romaniello

“…Abstract Background The precise etiology of septo-optic dysplasia (SOD) remains elusive, to date a complex interaction between genetic predisposition and prenatal exposure to environmental factors is believed to come into play. …”
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Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism by Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng

“…SEMAs and its receptors formed a complex network, and other members of the SEMA-signaling pathway might also be involved in the pathogenesis of IHH.…”
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Novel Approaches to Ileocolic and Perianal Fistulising Crohn’s Disease by Gaetano Luglio, Gianluca Cassese, Alfonso Amendola, Antonio Rispo, Francesco Maione, Giovanni Domenico De Palma

“…Nowadays, the introduction of both laparoscopy and novel surgical techniques, the improvement of recovery pathways, and the opening of new frontiers are allowing healthcare professionals to deal with complex and recurrent scenarios, trying to spare bowel and anal function, thus ensuring a better quality of life for the patient. …”
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Acute Childhood Cardiorenal Syndrome and Impact of Cardiovascular Morbidity on Survival by Wasiu A. Olowu

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Ray Tracing Methods for Correcting Chromatic Aberrations in Imaging Systems by Dmitry Reshidko, Masatsugu Nakanato, José Sasián

“…While the use of aberration formulas might be effective for some simple optical systems, it has limitations for complex and fast systems. …”
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Breast cancer in young patients. Peculiarities of prognosis and adjuvant hormone therapy (a literature review) by D. N. Kravchenko, A. A. Parokonnaya, M. I. Nechushkin, E. A. Nikitina, N. D. Hakurinova

“…Gradually are being collected data according to what age might be an independent factor exacerbating prognosis. …”
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Chromatin binding and silencing: Two roles of the same protein Lem2 by Ramón Ramos Barrales, Sigurd Braun

“…This further unveils a complex function of this protein at the interface between the nuclear periphery and silent chromatin, which might be preserved among the other members of this conserved family of LEM proteins.…”
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Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis by Yinyi Xiong, Li Li, Xiaorong Zhang

“…In contrast, it is capable of mediating multifaced neurological functions which are more complex than those of Drosophila Dscam. …”
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The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. by Aymeric P Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M J Lilley, Shawn Ahmed, Anton Gartner

“…Furthermore, GEN-1 acts redundantly with the 9-1-1 complex to ensure genome stability. Our study suggests that GEN-1 might act as a dual function Holliday junction resolvase that may coordinate DNA damage signaling with a late step in DNA double-strand break repair.…”
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A conversation on academic freedom and freedom of expression at the university by Robert C. Post, Jordi Pujol

“…At their best, universities function as ‘disciplinary communities’ who must act in professionally competent ways. …”
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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases by Núria Mach

“…Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. …”
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Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification by Kartik Balachandran, Philippe Sucosky, Ajit P. Yoganathan

“…Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. …”
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Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases by Meng Zhang, Jin Wei, Chang He, Liutao Sui, Chucheng Jiao, Xiaoyan Zhu, Xudong Pan

“…Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. …”
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Socio‑Economic Determinants of Construction Sector Development by Florian Gerth, Martin O’Brien, Karol S. Sikora

“…To do this, the study conducts a combination of regression analyses, Ordinary Least Squares in conjunction with Methods-of-Moments, while applying rigor to guarantee compliance with the CLR function assumptions. We find that the link between economic development and activity in construction is more complex than previously believed, with the role of the construction industry changing during economic development. …”
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A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder by Adriano Alberti, Willians Fernando Vieira, David Richer Araujo Coelho, Daniel Fernandes Martins

“…The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. …”
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Endocrine consequences of childhood obesity: a narrative review by Maroun Badr, Ghazwa El-Rabaa, Marianne Freiha, Andrzej Kędzia, Elżbieta Niechciał

“…If insulin resistance is not adequately managed, it might precipitate type 2 diabetes. Another common finding among children with obesity is thyroid dysfunction. …”
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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…Given the specificity of the observed defects, we are confident that the loss-of-mortalin model presented in this study will be useful for further dissection of the complex network of pathways that underlie the development of mitochondrial parkinsonism.…”
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Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty by Hendri Saputra, Sutanto Soehodho

“…Current problems of concern in aviation safety management involve a series of constraints, evaluation methods, and complex decision-making processes. Uncertainty in these problems adds complexity. …”
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Peripartum Cardiomyopathy-Induced Cardiogenic Shock Causing Hypoxic-Ischemic Encephalopathy in a COVID-19 Patient by Minh Khoi Le, Thanh Hieu Nguyen

“…The etiology of PPCM is not fully elucidated and is probably multifactorial, and viral infection might play some role. It has been documented that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly invades the cardiomyocytes and most commonly damages this vital organ via complex systemic devastating mechanisms. …”
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Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis by Robert Gross, Jennifer Davis, Julie Roth, Henry Querfurth

“…We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. …”
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