Inferring the temporal order of cancer gene mutations in individual tumor samples. by Jun Guo, Hanliang Guo, Zhanyi Wang

“…The initial mutations appear to be dedicated to acquiring the function of evading apoptosis, and some order constraints might reflect potential regularities. …”
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Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation. by Hichem Mahfouz, Antonella Ragnini-Wilson, Rossella Venditti, Maria Antonietta De Matteis, Cathal Wilson

“…The role of Trs20p, which is essential for viability and a component of all three complexes, and how it might function within each TRAPP complex, has not been clarified to date. …”
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A cohesin-independent role for NIPBL at promoters provides insights in CdLS. by Jessica Zuin, Vedran Franke, Wilfred F J van Ijcken, Antoine van der Sloot, Ian D Krantz, Michael I J A van der Reijden, Ryuichiro Nakato, Boris Lenhard, Kerstin S Wendt

“…Heterozygous mutations of NIPBL were found in 50% of the cases of Cornelia de Lange Syndrome (CdLS), a human developmental syndrome with a complex phenotype. However, no defects in the mitotic function of cohesin have been observed so far and the links between NIPBL mutations and the observed developmental defects are unclear. …”
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THE INFLUENCE OF CORONARY BYPASS ON ENDOTHELIAL AND ERECTILE DYSFUNCTION IN ISCHEMIC HEART DISEASE by S. A. Pomeshkina, E. V. Pomeshkin, T. Yu. Sergeeva, I. N. Sizova, O. L. Barbarash

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Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…Recent advances in genomics technologies have spurred unprecedented efforts in genome and exome re-sequencing aiming to unravel the genetic component of rare and complex disorders. While in rare disorders this allowed the identification of novel causal genes, the missing heritability paradox in complex diseases remains so far elusive. …”
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ASSOCIATION OF DEPRESSION AND ERECTILE DYSFUNCTION IN CARDIAC PATIENTS by S. A. Pomeshkina

“…The manifestations of the cause-effect relationship between ED and depression could vary: ED might be a symptom of depression, while depression could also be caused by ED, and the improvement in erectile function can reduce the severity of depressive symptoms. …”
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The Role of miRNA in Plant Adaptation to Abiotic Stress by Mohammad Hadi Taleb, Ahmad Arzani

“…The siRNAs then guide a protein complex called RISC (RNA-induced silencing complex) to complementary mRNA sequences. …”
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Analyse des représentations de professionnels impliqués dans deux parcours de sujets dits « incasables » by Gillonne Desquesnes, Nadine Proia-Lelouey, Didier Drieu

“…We elaborate the idea that the educational institution might care efficiently for them, if the containing function of health professionals, who would maintain supervision systems in order to protect the team of the attacks of the youngsters, was provided.…”
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The length and strength of compartmental interactions are modulated by condensin II activity. by Randi Isenhart, Son C Nguyen, Leah Rosin, Weihuan Cao, Patrick Walsh, Haris Muzaffar, Christopher E Ellison, Eric F Joyce

“…The spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained more enigmatic. …”
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Introduction: Melting Point by Sérgio Henrique Faria

“… We might think that high mountain regions, being remote and frozen, would be naturally isolated and protected from human action – the last untouched corners of the planet. …”
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CT IMAGING IN THE ELDERLY: ADDRESSING CHALLENGES AND ENHANCING DIAGNOSTIC ACCURACY by Uliana Pidvalna, Ihor Romaniuk, Anna Voitovych, Marianna Mirchuk

“…Educating medical staff on the needs of elderly patients ensures better comfort and care. Implementing complex solutions for optimizing CT imaging might improve the diagnostic outcomes and patient experience.…”
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What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus? by Hujun Shen, Hui Sun, Guohui Li

“…Poliovirus (PV) is a well-characterized RNA virus, and the RNA-dependent RNA polymerase (RdRp) from PV (3D(pol)) has been widely employed as an important model for understanding the structure-function relationships of RNA and DNA polymerases. …”
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CyTOF as a suitable tool for stratification and monitoring of cancer patients by Barbara Seliger, Chiara Massa

“…Abstract Despite the recent implementation of immunotherapies into clinical practice of various tumor types, the immunobiology of tumors and in particular the role and clinical relevance of the different immune cell populations and their function still remained unclear. Therefore, an in depth analysis of the complex landscape of immune cell populations and their soluble mediators in the peripheral blood and tumor microenvironment of cancer patients is urgently needed. …”
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Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis by Ran Guo, Hao Wang, Na Cui

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Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. by Enrica San Pietro, Mariagrazia Capestrano, Elena V Polishchuk, Alessio DiPentima, Alvar Trucco, Pasquale Zizza, Stefania Mariggiò, Teodoro Pulvirenti, Michele Sallese, Stefano Tete, Alexander A Mironov, Christina C Leslie, Daniela Corda, Alberto Luini, Roman S Polishchuk

“…Here, we examine the mechanisms of generation and the function of these tubules. In principle, tubule formation might depend on several protein- and/or lipid-based mechanisms. …”
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Path Optimization Strategy for Unmanned Aerial Vehicles Based on Improved Black Winged Kite Optimization Algorithm by Shuxin Wang, Bingruo Xu, Yejun Zheng, Yinggao Yue, Mengji Xiong

“…The Black-winged Kite Optimization Algorithm (BKA) is likely to experience a sluggish convergence rate when confronted with the optimization of complex multimodal functions. The fundamental algorithm has a tendency to get stuck in local optima, thus rendering it arduous to identify the global optimal solution. …”
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Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. by Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays

“…As RPs co-assemble into one multi-subunit complex, mutation of the genes that encode RPs might be expected to give rise to phenocopies, in which the same phenotype is associated with loss-of-function of each individual gene. …”
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Heterogeneidade nos deficits de percepção do movimento em perturbações do desenvolvimento: o caso do Autismo e da Síndrome de Williams by Ana Maria Abreu, Scania de Schonen

“…Moreover, a different pattern of low level motion detection deficits might underlie each of these developmental disorders. …”
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Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. by Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu

“…Because Vimar could co-immunoprecipitate with Miro in vitro, we speculated that Vimar might be the GEF of Miro. In support of this hypothesis, a loss-of-function (LOF) vimar mutant rescued mitochondrial enlargement induced by a gain-of-function (GOF) Miro transgene; whereas a GOF vimar transgene enhanced Miro function. …”
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Identification of subcellular localization of Arabidopsis AGO2 by ZHAO Li, XIA Wenqiang, CAI Xinzhong

“…Some members of AGO family proteins have been found to bind small RNAs, which are generated through the function of DCLs, to form a RNA-induced silencing complex (RISC), leading to RNA silencing at either transcriptional or post-transcriptional level, thus results in alternation in development, abiotic and biotic stress resistance. …”
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