The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms by Tong Sun, Xiao Han

“…Since mammalian PIWI subfamily proteins are mainly germline specific, it was once thought that piRNAs might only function in the gonadal cells. However, evidence from the later research suggest that piRNAs are broadly expressed in many kinds of somatic cells and are involved in numerous pathological condition far beyond those have been reported in the germline. …”
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Immune cells and the trajectories of depression, anxiety, and cognitive function among people with amyotrophic lateral sclerosis by Yihan Hu, Elie Deeba, Ulf Kläppe, Linn Öijerstedt, John Andersson, Nicolas Ruffin, Fredrik Piehl, Caroline Ingre, Fang Fang, Christina Seitz

“…Background: Amyotrophic lateral sclerosis (ALS) represents a complex syndrome characterized by motor, psychiatric, and cognitive symptoms, where associations between cellular immune features and non-motor manifestations remain unknown. …”
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Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma by Elisabeth Jehli, Fabienne Burri, Niklaus Denier, Franz Moggi, Andrea Federspiel, Roland Wiest, Maria Stein, Tobias Bracht, Matthias Grieder, Leila M. Soravia

“…Here, we additionally aimed to investigate fronto-limbic functional connectivity (FC) in patients with AUD with (AUD-CT) and without (AUD-noCT) CT. …”
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Diaphragm Fatigue Does Not Impact Breathing Mechanics or Function in People with Chronic Low Back Pain by Mitchell UH, Robinson LT, Brinkman J, Bruening DA, Bowden AE, Allen SP

“…Chronic low back pain (CLBP) is a complex musculoskeletal condition and has been associated with respiratory problems and altered breathing mechanics. …”
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Effect of lipid peroxidation on the allergenicity and functional properties of soybean β-conglycinin (7S) and glycinin (11S) by Liying Ye, Liangtao Lü, Xiao Lin, Kan He, Xiaoquan Yang, Zhili Wan, Lizhong Liu, Haiqian Wu, Shaojun Xing, Xuli Wu

“…A mouse model showed that oxidation reduced the IgE, IgG, and IgG1 levels, as well as reduced histamine and mMCP-1 release in serum, which might suppress the allergic reaction. In conclusion, the lipid peroxidation treatment likely causes changes to the functional properties of soybean, decreasing the potential allergenicity of 7S and 11S.…”
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Vitamin K Epoxide Reductase Complex (VKORC1) Electrochemical Genosensors: Towards the Identification of <i>1639 G>A</i> Genetic Polymorphism by Tiago Barbosa, Stephanie L. Morais, Renato Carvalho, Júlia M. C. S. Magalhães, Valentina F. Domingues, Cristina Delerue-Matos, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Marlene Santos, Maria Fátima Barroso

“…However, warfarin has a limited therapeutic index and might cause bleeding and other clinical problems. …”
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Hidden Scars: The impact of torture, traumatic brain injury, and PTSD on executive functions - a narrative review by Miguel Diaz, Inger Wallin Lundell

“…Introduction: Victims of torture are often subjected to physical violence, which can result in traumatic brain injury (TBI) and PTSD. Executive functions encompass a complex set of higher cognitive abilities that include memory, inhibitory control, cognitive flexibility, planning, reasoning, and problem solving. …”
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Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation by Juliane Lokau, Maria Agthe, Christoph Garbers

“…The cytokines interleukin-11 (IL-11) and IL-6 are important proteins with well-defined pro- and anti-inflammatory functions. They activate intracellular signaling cascades through a homodimer of the ubiquitously expressed signal-transducing β-receptor glycoprotein 130 (gp130). …”
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Parasite community of the pelagic thresher Alopias pelagicus (Lamniformes) as additional indicator of trophic network status and functioning by Mario Santoro, Flavia Occhibove, Luigi Maria Cusano, Marialetizia Palomba, Bernald Pacheco-Chaves, José Miguel Carvajal-Rodríguez, Monica Monge-Amador, Alicia Rojas, Alberto Solano-Barquero

“…Parasite communities of sharks, which have high structural importance within trophic webs, might well be included among bioindicators of trophic network functioning. …”
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Endophytic Bacterial Community, Core Taxa, and Functional Variations Within the Fruiting Bodies of <i>Laccaria</i> by Kaixuan Zhang, Xin Chen, Xiaofei Shi, Zhenyan Yang, Lian Yang, Dong Liu, Fuqiang Yu

“…By analyzing bacterial diversity, community structure, and function through 16S rRNA sequencing, we observed the following: (1) In total, 4,840,291 high-quality bacterial sequences obtained from the fruiting bodies were grouped into 16,577 amplicon sequence variants (ASVs), and all samples comprised 23 shared bacterial ASVs. (2) The <i>Allorhizobium</i>-<i>Neorhizobium</i>-<i>Pararhizobium</i>-<i>Rhizobium</i> complex was found to be the most abundant and presumably coexisting bacterium. (3) A network analysis revealed that endophytic bacteria formed functional groups, which were dominated by the genera <i>Allorhizobium</i>-<i>Neorhizobium</i>-<i>Pararhizobium</i>-<i>Rhizobium</i>, <i>Novosphingobium</i>, and <i>Variovorax</i>. (4) The diversity, community structure, and dominance of ecological functions (chemoheterotrophy and nitrogen cycling) among endophytic bacteria were significantly shaped by geographic location, habitat, and fungal genotype, rather than fruiting body type. (5) A large number of the endophytic bacteria within <i>Laccaria</i> are bacteria that promote plant growth; however, some pathogenic bacteria that pose a threat to human health might also be present. …”
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Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study by Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu

“…Abstract Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. …”
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Individual alpha frequency tACS reduces static functional connectivity across the default mode network by Martín Carrasco-Gómez, Martín Carrasco-Gómez, Martín Carrasco-Gómez, Alejandra García-Colomo, Alejandra García-Colomo, Jesús Cabrera-Álvarez, Jesús Cabrera-Álvarez, Alberto del Cerro-León, Alberto del Cerro-León, Carlos J. Gómez-Ariza, Andrés Santos, Andrés Santos, Fernando Maestú, Fernando Maestú, Fernando Maestú

“…These findings suggest that tACS might modulate FC in a more complex manner than previously thought, highlighting the need for further research into the personalized application of neuromodulation techniques, as well as its potential therapeutic implications for conditions like Alzheimer’s disease.…”
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Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury by Peng-Fei Dong, Tian-Bin Liu, Kai Chen, Dan Li, Yue Li, Cai-Yu Lian, Zhen-Yong Wang, Lin Wang

“…Conclusion: In summary, these findings reveal that TFEB phosphorylation, nuclear export and acetylation independently suppress TFEB activity to cause Cd-induced AKI via regulating autophagy-lysosome function, suggesting that TFEB activation might be a promising treatment strategy for Cd-induced AKI.…”
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The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin

“…However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic. …”
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Multi-directional deformation for coordinating isotropy and strength-ductility synergy in a CoCrNi alloy by Na Lin, Zhicheng Miao, Mingcan Li, Rumeng Huang, Kaiyuan Zheng, Zhaowen Huang, Donghui Wen, Cong Zhang, Anding Wang

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Clinical and functional reasons for internal thoracic artery Novocain blocks during in-patient coronary heart disease treatment by I. A. Latfullin, I. V. Bilalov, R. R. Bilalova

“…Novocain internal thoracic artery block might be a method of choice in complex treatment of resistant angina.…”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

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Characterization of phytoplankton size-structure based productivity, pigment complexes (HPLC/CHEMTAX) and species composition in the Cochin estuary (southwest coast of India): spec... by Meenu Paul, Madhu Nikathithara Velappan, Ullas Nanappan, Vineetha Gopinath, Rehitha Thekkendavida Velloth, Ashwini Rajendran, Maheswari Nair, Anil Peariya

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More than just a broken limb: Unmasking CRPS in Pakistan by Zahra Aamir Khan

“… Madam, Complex Regional Pain Syndrome (CRPS) is a debilitating pain disorder, usually affecting one limb, and occurring after a trauma. …”
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Seasonal effects of plant functional groups on molecular biogeochemistry of dissolved organic matter in porewater of a poor fen by Zhimin Song, Maryam Khaksari, Erik A. Lilleskov, Erik A. Lilleskov, Evan S. Kane, Evan S. Kane, Paul V. Doskey, Paul V. Doskey

“…Studies in which vascular plant functional groups (PFGs) in peatlands have been manipulated to mimic the potential effects of a warming climate on DOM are scarce. …”
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