Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications by Can Qi, Can Qi, Ziwei Zhao, Lin Chen, Le Wang, Yun Zhou, Guochen Duan, Guochen Duan

“…Differential analysis was performed to identify DEGs between subtypes. Functional items and related pathways of DEGs were identified using enrichment analysis. …”
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An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer by Yun Hu, Lanqiao Sun, Jinhua Wang, Yuan Ji, Lili Feng

“…We divided BC patients into lymph node positive and negative groups to identify immune-related lymph node-associated differentially expressed genes (DEGs) for functional enrichment analysis and protein-protein interaction (PPI) network. …”
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Altered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure by Haichao Wang, Wen Xue, Jiafen Cheng, Yipei He, Yaxiang Song, Dayong Hu, Ai Peng, Changbin Li, Hui Bao

“…These changes were accompanied by functional alterations in distinctive microbial pathways. …”
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Targeting miR‐223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds by Maiko de Kerckhove, Katsuya Tanaka, Takahiro Umehara, Momoko Okamoto, Sotaro Kanematsu, Hiroko Hayashi, Hiroki Yano, Soushi Nishiura, Shiho Tooyama, Yutaka Matsubayashi, Toshimitsu Komatsu, Seongjoon Park, Yuka Okada, Rina Takahashi, Yayoi Kawano, Takehisa Hanawa, Keisuke Iwasaki, Tadashige Nozaki, Hidetaka Torigoe, Kazuya Ikematsu, Yutaka Suzuki, Katsumi Tanaka, Paul Martin, Isao Shimokawa, Ryoichi Mori

“…Abstract Argonaute 2 bound mature microRNA (Ago2‐miRNA) complexes are key regulators of the wound inflammatory response and function in the translational processing of target mRNAs. …”
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Decoupling working memory impairment from grey matter volume changes in female patients with fibromyalgia: Moderating effect of depression by Ana Belén del Pino, Irene Peláez, Alejandro García-Romero, Maria Luisa Fernández-Sánchez, Paloma Barjola, Vanesa Soto-León, Antonio Oliviero, Francisco Mercado

“…Moderation analyses highlighted the importance of considering affective symptoms of fibromyalgia, such as depression, to characterize associations between local grey matter volumes in the insula and prefrontal cortices (orbitofrontal and ventrolateral prefrontal cortex) with working memory functioning. These results suggest that moderate to severe symptoms of depression appear to be critical for understanding the emergence of associations between grey matter volume and working memory, offering valuable new insights into this complex relationship. …”
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Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation by Alvaro Rada‐Iglesias

“…Abstract In embryonic stem cells (ESCs), silent genes with major developmental functions display a unique epigenetic state in which strong and broad binding by Polycomb repressive complexes (PRCs) is accompanied by the presence of poised RNA polymerase II (RNAPII) and activating histone marks (e.g. …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…However, it is unclear whether and to which extent these events might affect frailty, fastening its development or hampering its reversion. …”
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Improved corrosion inhibition effect of a green three-component compound to Q235 steel in acidic solution by Chengjia Bao, Weijian Qi, Zhuanjun Zhu, Ting Xu, Long Zhao, Yanhong Ma, Yang Liu, Bowen Yang, Xueru Luo, Hui Yun, Xiaojuan Li

“…The synergistic anticorrosion layer not only prevented steel surface from corrosive solution attack, but also increased the resistance to retard the charge transfer in the solution. The results might shed new insight in the application of green complex for steel corrosion inhibition.…”
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Neural Network Dynamics without Minimizing Energy by Mau-Hsiang Shih, Feng-Sheng Tsai

“…Studies of such neural network systems are typically based on the aspect of energy minimization. However, when the complexity and the dimension of neural network systems go up, the use of energy functions might have its own limitations to study CAM. …”
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Edgetic perturbation models of human inherited disorders by Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal

“…Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. …”
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PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy by Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera

“…It is an insidious multifactorial disease caused by complex and partially unknown mechanisms that include metabolic dysregulation, local inflammation, fibrosis, and cardiomyocyte apoptosis. …”
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Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach by Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Mohammed Cherkaoui, Maged Gomaa Hemida

“…Additionally, 50 ns molecular dynamics simulations highlighted the structural stability and compactness of the GS441524-PB2/CBD complex, further supporting its potential as a promising antiviral candidate. …”
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Agreement of glomerular filtration rate estimation equations for chemotherapy dosing in cancer patients at a tertiary referral hospital in Sub-Saharan Africa. by Wubshet Jote Tolossa, Tigist Workneh Leulseged, Abdu Adem, Feyissa Challa, Tirumebet Mezgebu, Ruth S Aytehgeza, Nebiat Adane Mera, Kalsidagn Girma Asfaw, Momina M Ahmed, Kebede H Begna

“…<h4>Introduction</h4>Narrow therapeutic indices of chemotherapeutic agents necessitate precise dosing to ensure efficacy and minimize nephrotoxicity. Due to the complexity of directly measuring Glomerular filtration rate (GFR), renal dosing is usually based on GFR estimation equations. …”
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Neural signatures underlying the effect of social structure on empathy and altruistic behaviors by Xia Tian, Zixin Zheng, Renhui Li, Yue-Jia Luo, Chunliang Feng

“…Furthermore, whole-brain and local neural patterns in the anterior insula and premotor cortex robustly discriminated painful (but not non-painful) stimulation of different innocents, suggesting that social structure altered emotional and sensorimotor aspects of empathy. These alterations might be driven by top-down regulation, as indicated by heightened functional connectivity between the lateral prefrontal cortex and sensorimotor areas, as well as between the anterior insula and subgenual anterior cingulate cortex when witnessing the pain of innocents resembling fair (vs. unfair) targets. …”
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Single-Nucleus RNA Sequencing Reveals the Transcriptome Profiling of Ovarian Cells in Adolescent <i>Cyprinus carpio</i> by Mingxi Hou, Jin Zhang, Qi Wang, Ran Zhao, Yiming Cao, Yingjie Chen, Kaikuo Wang, Ning Ding, Yingjie Qi, Xiaoqing Sun, Yan Zhang, Jiongtang Li

“…In addition, the dynamic genes expressed in granulosa cells might relate to the complex communication between different cell types. …”
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Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery by Floriana Ferro, Caterina Gaspari, Giulia Manfrè, Federica Cernigliaro, Daniela D’Agnano, Ruben Panzica, Edvige Correnti, Maria Rosita Ruta, Francesca Marchese, Renata Pitino, Mariarita Capizzi, Giuseppe Santangelo, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli

“…Headache represents one of the most prevalent and disabling conditions in the pediatric population, with significant repercussions on mental and psychological well-being, as well as on academic achievement and social functioning, ultimately leading to a marked reduction in quality of life. …”
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Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration by Xiaoyu Zhang, Qianping Guo, Jiawei Fang, Qi Cheng, Zhuang Zhu, Qifan Yu, Huan Wang, Youzhi Hong, Chengyuan Liu, Huilin Yang, Caihong Zhu, Bin Li, Li Ni

“…RNA sequencing suggested that inhibition of the Nod-like receptor signaling might be the mechanism behind their therapeutic effects. …”
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Solid State Transformers: A Review—Part I: Stages of Conversion and Topologies by Dragoș-Mihail Predescu, Ștefan-George Roșu

“…Converter functionalities are derived based on the number of stages. …”
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Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets by Nira Hernández-Martín, Ignacio Pozo-Cabanell, Rubén Fernández de la Rosa, Luis García-García, Francisca Gómez-Oliver, Miguel Ángel Pozo, Mirjam Brackhan, Pablo Bascuñana

“…Main body Animal models have proven to be a crucial tool for studying epileptogenesis, many exhibiting cellular, molecular, and functional alterations that resemble those found in human patients. …”
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Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway by Jiale Cai, Xinya Zheng, Xiongbo Luo, Wenli Cui, Xinrui Ma, Shuyi Xu, Lanya Fu, Jiaqi Zhang, Yizhou Xu, Yunlun Li, Ye He, Xianghai Wang, Jiasong Guo

“…Overall, this is the first study to demonstrate that microglial RhoA is essential for SCI repair, the Arhgap25/HIF-1α pathway mediated glucose metabolism might enlighten a novel insight to enrich the understanding on the complex roles of RhoA and microglia in SCI repair. …”
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