Identification of biomarkers and target drugs for melanoma: a topological and deep learning approach by Xiwei Cui, Xiwei Cui, Jipeng Song, Qingfeng Li, Jieyi Ren

“…Advanced network analysis tools were employed to identify structural disparities and functional module shifts. Key driver genes were validated through topological centrality metrics. …”
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Introducing B-Sweep: An Innovative Bird-Repelling Device Powered by Solar Cells and Sound Waves, Efficiently Protecting Against Bird Strikes in Airport Airsides by Muhammad Rafli Fazal, Direstu Amalia, Jasmin Masyirianti, Akbar Nopriansyah Saputra, Yudhistira Agung Mahendra, Muhammad Khafid Ridwan, Sukahir Sukahir, Yeti Komalasari

“…Due to its sound and wave, the sweep audio signal might deter birds from nesting and visiting the airport airside. …”
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Effects of a Mobile Storytelling App (Huiyou) on Social Participation Among People With Mild Cognitive Impairment: Pilot Randomized Controlled Trial by Di Zhu, Abdullah Al Mahmud, Wei Liu

“…Notably, storytelling performance improved markedly, evidenced by increases in story sharing duration and complexity. Although overall improvements in Assessment of Life Habits (P=.14), Social Connectedness Scale–Revised (P=.59), and Subjective Well-Being Scale (P=.26) scores were not statistically significant, the large effect sizes observed suggest potential benefits of the Huiyou app that might be obscured by the study’s small sample size. …”
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AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway by Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He, Zeyuan Li

“…Methods In this study, we examined adaptor-related protein complex 5 subunit ζ1 (AP5Z1) expression in liver cancer and nearby noncancerous tissues to explore its effects on HCC cell growth, death, and autophagy. …”
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Doing Good Instead of Doing Well? What Lawyers Could be Doing in a World of “Too Many” Lawyers by Carrie Joan Menkel-Meadow

“…The paper explores issues of what constitutes “legal knowledge and expertise” and how such knowledge might be deployed to solve complex social and legal problems outside of conventional legal professional boundaries. …”
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NCBP2 predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis by Shichao Li, Yulan Wang, Xi Yang, Miao Li, Guoxiang Li, Qiangqiang Song, Junyu Liu

“…Background The cap-binding complex (CBC) plays a crucial role in facilitating gene expression by safeguarding mRNA from nonsense-mediated decay, promoting mRNA splicing, 3′-end processing, and facilitating nuclear export. …”
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Wisdom of the Established Pattern by Joel Janhonen

“…Attaining an exhaustive comprehension of the complex interactions of natural and social worlds is impossible, so we have evolved to operate by relying on a built-in navigation system. …”
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Three-Dimensional Printing and Its Impact on the Diagnosis and Treatment of Neurodegenerative Disease by Sameer Patil, Ami Thakkar, Ginpreet Kaur, Amisha Vora, Ritu Chauhan, Seema Ramniwas, Abhishek Chauhan, Damandeep Kaur, Hardeep Singh Tuli

“…Neurodegenerative disorders include Alzheimer’s and Parkinson’s, both of which lead to progressive loss of neurons resulting in the severe loss of cognitive and motor functions. These diseases are among the heavy burdens on global healthcare systems largely because there is no cure, and current treatments apply almost entirely to controlling symptoms rather than disease progression. …”
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Microbiological and Physicochemical Approach in the Feeding of Superworm (<i>Zophobas morio</i>) with Petroleum-Derived Polymer Diets by Brandon R. Burgos, Fabiola Morales, Rodrigo Morales-Vera, Cristian Valdés, Jorge Y. Faundez, Eduardo Pereira de Souza, Flavio Henrique-Silva, Ariel D. Arencibia

“…However, recently, some studies have shown that some insects might be able to adapt, consuming a wide range of hydrocarbon base polymers. …”
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Immunoregulatory Effects of <i>Codonopsis pilosula</i> Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice by Yan Long, Hongfei Ji, Jiajing Yang, Haiyu Ji, Keyao Dai, Wenjie Ding, Guoqiang Zheng, Juan Yu

“…This study aimed to investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. …”
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Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Effic... by Shadi Jacob Khoury, Yazeed Zoabi, Mickey Scheinowitz, Noam Shomron

“…The results suggest that booster shots might be necessary for this population to ensure adequate immunity, given the observed immune response patterns. …”
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Cycloserine resistance among drug-resistant tuberculosis cases in Taiwan by Sheng-Han Wu, Hsin-Yi Liu, Kuang-Hung Liu, Hseuh-Chien Hsiao, Ruwen Jou

“…Of the 114 MTBC isolates, we found 5 (4.4%) CS-MGIT-resistant isolates, which all harbored mutations in the alr gene, including three previously known mutations M343T, T20M, L113R, and a novel mutation R243S, whereas seven low-MIC isolates harboring alr Q30R mutations might not be associated with CS resistance. Notably, M1I, E118K, and A184T in the ald gene and L113R, R243S, S261N, and M343T in the alr gene were predicted to have a destabilizing effect, which could interfere with protein functions and induce drug resistance. …”
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Microcirculatory Disorders in Infant Respiratory Distress Syndrome (Morphological Study) by S. A. Perepelitsa, A. M. Golubev, V. V. Moroz

“…In cases of unfavorable outcomes, dilation of arterial and venous lumen and vascular wall thickening might be considered as principal signs of microcirculatory disorders. …”
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Incremental data integration for tracking genotype-disease associations. by Tomasz Konopka, Damian Smedley

“…Incremental integration is thus a suitable framework for tracking functional annotations and linking to complex human pathology.…”
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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…These findings demonstrate that peroxisomal impairments in microglia exacerbate inflammatory response and ROS/NO production, affecting the survival of neurons and oligodendrocytes, as well as neuronal morphology and function. This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. …”
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Synergetic Urban Landscape Planning in Rotterdam by Nico Tillie

“…This renders the assignment more complex but certainly no less landscape architectonic. …”
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SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice by Ziying Jiang, Bin Liu, Tangsheng Lu, Xiaoxing Liu, Renjun Lv, Kai Yuan, Mengna Zhu, Xinning Wang, Shangbin Li, Song Xu, Xinyu Wang, Yifei Wang, Zhenfang Gao, Peiqing Zhao, Zongyong Zhang, Junwei Hao, Lin Lu, Qingqing Yin

“…More in-depth analysis of oligodendrocytes (OLs) distinguished five subclusters, indicating different functional states of OLs and transcriptional changes in each subcluster. …”
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Phylogenomic Signatures of a Lineage of Vesicular Stomatitis Indiana Virus Circulating During the 2019–2020 Epidemic in the United States by Selene Zarate, Miranda Bertram, Case Rodgers, Kirsten Reed, Angela Pelzel-McCluskey, Ninnet Gomez-Romero, Luis L. Rodriguez, Christie Mayo, Chad Mire, Sergei L. Kosakovsky Pond, Lauro Velazquez-Salinas

“…Collectively, our study reveals the complex dynamics that accompany the evolution of an epidemic lineage of VSIV in nature. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine by Coskun S, Varol S, Ozdemir HH, Agacayak E, Aydın B, Kapan O, camkurt MA, Tunc S, Cevik MU

“…Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. …”
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