Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study by Wenhua Li, Suya Ma, Yunong Tian

“…ABSTRACT Background and Aims Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a poorly understood etiology. …”
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An efficient strategy to promote food waste composting by adding black soldier fly (Hermetia illucens) larvae during the compost maturation phase by Jiawei Quan, Yumei Wang, Yu Wang, Chunxing Li, Zengwei Yuan

“…Furthermore, BSFL introduction might enhance metabolic functions such as glycolysis, inosine monophosphate biosynthesis, gluconeogenesis, and lysine biosynthesis. …”
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Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome by Mingshuang Li, Conglin Ren, Chenxia Wu, Xinyao Li, Xinyi Li, Wei Mao

“…Protein-protein interaction (PPI) network was mapped in Cytoscape, followed by screening of hub genes based on the Molecular Complex Detection (MCODE) plug-in. Functional Enrichment analysis tool (FunRich) and Database for Annotation, Visualization and Integrated Discovery (DAVID) were used to predict miRNAs and TFs, respectively. …”
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Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity by Fernanda Raiqueo, Roberto Amigo, José L. Gutiérrez

“…In the yeast Saccharomyces cerevisiae, Reb1 and Abf1 are among the transcriptions factors that perform this molecular function. These factors are thought to act as a barrier to nucleosome sliding that chromatin remodeling complexes such as ISW1a perform towards this region, being binding affinity a critical feature to act as a barrier. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Conclusion This review highlights that settings providing care for people with a LD are complex care environments, and thus reducing the use of RP is likely to require complex interventions, involving different stakeholders and approaches as our programme theory suggests. …”
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Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…Limitations The review was limited by a paucity of theory and economic evaluations, so it is unclear how interventions might function or their potential cost-effectiveness. …”
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Exploring the therapeutic potential of different sources of mesenchymal stem cells: a novel approach to combat burn wound infections by Shahrzad Aliniay-Sharafshadehi, Mohammad Hasan Yousefi, Mohammad Hasan Yousefi, Mohammad Ghodratie, Mojtaba Kashfi, Mojtaba Kashfi, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Seyed Mehdi Ghoreyshiamiri

“…On the other hand, a burn wound infection creates an environment that is conducive to the growth of bacteria and might put the patient at risk for sepsis. In addition, scarring is unavoidable, and this results in patients having functional and cosmetic issues. …”
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Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM by Christian Schwarzenbach, Justus Rinke, Juliana B. Vilar, Jason Sallbach, Larissa Tatsch, Ariane Schmidt, Anna Schöneis, Birgit Rasenberger, Bernd Kaina, Maja T. Tomicic, Markus Christmann

“…Abstract Therapy-induced senescence (TIS) is a major challenge in cancer therapy as senescent cancer cells provoke local and systemic inflammation and might be the cause of recurrences. Elucidation of pathways leading to TIS is of utmost importance for establishing strategies to counteract this. …”
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The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer by Li Qiu, Shourong Wu, Lei Zhang, Wenfang Li, Debing Xiang, Vivi Kasim

“…This review summarizes the current knowledge on the functional roles and underlying molecular mechanisms of IGF2BP1 in regulating cancer hallmarks. …”
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Identification of palmitoylated biomarkers in non-alcoholic fatty liver disease via integrated bioinformatics analysis and machine learning by Zheng Liu, Xiaohong Wang, Mingzhu Xiu, Rui Luo, Xiaomin Shi, Yizhou Wang, Yusong Ye, Ruiyu Wang, Sha Liu, Muhan Lv, Xiaowei Tang

“…Abstract Non-alcoholic fatty liver disease (NAFLD) is a global health challenge with complex pathogenesis and limited diagnostic biomarkers. …”
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Phenomenology of repetitive and restrictive behaviors and sensory phenomena in neurodevelopmental disorders: an exploratory study by A. Vigil-Pérez, A. Blázquez, B. Garcia-Delgar, A. E. Ortiz, R. Borràs, A. Morer, RCalvo Escalona, L. Lázaro

“…Abstract Background Repetitive and restrictive behaviors (RRB) include simple motor stereotypes, tics and complex ritualized and rigid behaviors that are core symptoms in neurodevelopmental disorders such as obsessive–compulsive disorder (OCD), Tourette syndrome (TS) or autism spectrum disorder (ASD). …”
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Bioinformatics analysis of lncRNA and mRNA differentially expressed in patients with cervical cancer by Xiaohua An, Xiaohua An, Xiaoxue Huang, Qiujie Yu, Qiujie Yu, Yiyue Tang, Yan Wang, Yan Wang, Huasu Chen, Huasu Chen, Yafei Zhang, Yafei Zhang, Qianhao Huang, Qianhao Huang, Yudi Rao, Yudi Rao, Guomei Hu, He Zha

“…Further analysis indicated that the 20 antisense lncRNAs with the most remarkable differences might exert biological functions by influencing their corresponding mRNAs. …”
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Identification and validation of oxidative stress-related genes for the diagnosis of sepsis-induced acute lung injury. by Xue Fu, Jiawei Dong, Jian Yang, Xiaotian Zhang, Sen Wang, Shangkun Cai, Yiwei Zhang, Meng Zhang

“…Sepsis-induced acute lung injury (ALI) is an inflammatory pulmonary condition characterized by a complex pathophysiological mechanism. The development and progression of sepsis-induced ALI are accompanied by significant oxidative damage. …”
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Analysis of Flow-induced Vibration Characteristics of Fuel Rods Using POD and DMD Methods by MIN Guangyun1, JIANG Naibin1, 2

“…To unravel the intricacies of this complex phenomenon, a sophisticated high-fidelity finite element model of fuel rods was meticulously constructed. …”
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Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…To maintain synchronization in power systems, frequency must remain constant; disruptions in the proper balance of production and load might produce frequency variations, risking serious issues. …”
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Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Abstract Background Targeting lung cancer while sparing healthy cells is the cornerstone of chemotherapy; however, bioavailability issues and complex biological barriers prevent their accumulation in the tumor sites. …”
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Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation by Tessa Nelemans, Ali Tas, Nina L. de Beijer, George M. C. Janssen, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert

“…P62 thus plays an antiviral role during USUV infection, although this antiviral effect might also be related to its functions outside the autophagy pathway, such as modulation of the immune response. …”
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從工具示能性與關係行動主體之觀點 探討偏鄉教育系統賦能策略之研究 Investigating the Construction of Empowerment Action Models in Remote Educational Systems Through the Lenses of Tool Affordance and Relational Age... by 陳佩英 Peiying Chen, 洪琴雯 Chin-Wen Hung

“…However, these existing disadvantages might be transformed by means of implementing the new National Curriculum Guidelines in 2019. …”
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Pangolin scales as adaptations for innate immunity against pathogens by Xuechen Tian, Li Chen, Jinfeng Zhou, Enbo Wang, Mu Wang, Nicholas Jakubovics, Jing Li, Kunping Song, King Tong Lau, Klaus-Peter Koepfli, Siyuan Zhang, Geok Yuan Annie Tan, Yixin Yang, Siew Woh Choo

“…Previous studies indicated pangolin scale might provide an important mechanical defense to themselves. …”
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Addressing the need for non-invasive lung assessment with time-resolved diffuse optics by Giulia Maffeis, Nicola Serra, Alessandro Bossi, Alessandro Bossi, Elisabetta Avanzi, Alberto Dalla Mora, Laura Di Sieno, Rinaldo Cubeddu, Antonio Pifferi, Antonio Pifferi, Paola Taroni, Paola Taroni

“…Photons in the 600–1,300 nm range might have the potential to reach lungs and provide compositional and functional information. …”
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