Using the Behaviour Change Wheel to develop an intervention to improve conversations about recovery on the stroke unit. by Louisa-Jane Burton, Anne Forster, Judith Johnson, Thomas F Crocker, David J Clarke

“…This study aimed to begin development of a novel complex intervention to improve conversations about recovery on stroke units.…”
Get full text

Lightweight deep learning system for automated bone age assessment in Chinese children: enhancing clinical efficiency and diagnostic accuracy by Pang Hai, Zhang Bin, Liu Kesheng, Li Cong, Xu Fei

“…This lightweight design reduces computational complexity, enabling faster inference while maintaining diagnostic precision. …”
Get full text

Who understands and how? – exploring nurses’ perceptions of the readability and usability of instructions written by hospital pharmacists by Henri Satokangas, Kirsi Kvarnström, Hanna M. Tolonen

“…Results The interviewed nurses (n = 9) consistently found the instructions somewhat challenging, primarily due to their length, complex structure and limited accessibility. While the interviewees stated that the instructions did not present personal difficulties, they expressed concern that other staff in the ward might struggle with the instructions. …”
Get full text

Global Longitudinal Strain: A Novel Predictor of Postoperative Outcomes in Children Undergoing Rheumatic Valve Surgery by Sowmya Kasturi, Srinath Reddy Narahari, Anand Kumar Gowdhaman, Dipesh Trivedi, Ganapathy Subramaniam, Abhinav Singh Chauhan

“…Background: Valve surgery in patients with paediatric rheumatic heart disease is challenging, owing to the complexities involved in the anatomy and hemodynamics. …”
Get full text

Modal verbs in Indonesian and Malaysian English textbooks for secondary schools: A corpus-driven study by Ikmi Nur Oktavianti, Noor Raha Mohd Radzuan, Bambang Widi Pratolo, Surono Surono, Tri Rina Budiwati, Shifak Aisyah

“…However, modal verbs are complex grammatical units since they have multiple functions and meanings. …”
Get full text

Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment by Boxuan Wei, Jieyu Gu, Ran Duan, Bowen Gao, Min Wu, Shengliang Zhou, Xiaolu Huang, Feng Xie

“…Antiapoptotic activity and immune evasion might explain how such heterogeneous cells have avoided elimination. …”
Get full text

mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity by Michal Fila, Laura Diaz, Joanna Szczepanska, Elzbieta Pawlowska, Janusz Blasiak

“…The structure of Arc is similar to the viral GAG (group-specific antigen) protein, and phylogenic analysis suggests that Arc may originate from the family of Ty3/Gypsy retrotransposons. Therefore, Arc might evolve through “domestication” of retroviruses. …”
Get full text

De novo characterization of microRNAs in oriental fruit moth Grapholita molesta and selection of reference genes for normalization of microRNA expression. by Xiu Wang, Yisong Li, Jing Zhang, Qingwen Zhang, Xiaoxia Liu, Zhen Li

“…MicroRNAs (miRNAs) are a group of endogenous non-coding small RNAs that have critical regulatory functions in almost all known biological processes at the post-transcriptional level in a variety of organisms. …”
Get full text

Genomics and proteomics of the liver fluke <em>Opisthorchis felineus</em> by V. A. Mordvinov, N. I. Ershov, O. G. Zaparina, M. Y. Pakharukova

“…Data on the O. felineus genomics and proteomics provide first insights into the structural and functional organization of the genome of this parasitic flatworm with a complex life cycle as well as provide a significant contribution to our understanding of “host-parasite” interaction and evolution of this group of parasitic flatworms.…”
Get full text

Investigating the dual role of mitochondrial and nuclear genome variants in pediatric cardiomyopathies by M. Arda Temena, Ebru Erzurumluoglu Gokalp, Ezgi Susam, Duygu Cinar, Hikmet Kiztanir, Pelin Kosger, Beyhan Durak Aras, Sevilhan Artan, Oguz Cilingir

“…Specifically, a variant in FOXRED1, encoding FAD-dependent oxidoreductase domain-containing protein-1 which functions in mitochondrial complex I stability, and another variant in cytochrome c oxidase-I, MT-CO1, crucial for aerobic metabolism, were identified in two siblings with hypertrophic cardiomyopathy. …”
Get full text

Bagasse minority pathway expression: Real time study of GH2 β-mannosidases from bacteroidetes. by Tatiane Fernanda Leonel, Elisângela Soares Gomes Pepe, Tereza Cristina Luque Castellane, Juliana da Silva Vantini, Michelli Inácio Gonçalves Funnicelli, Eliana Gertrudes de Macedo Lemos

“…The degree of novelty-as demonstrated by the low identity with previously characterized enzymes; the remarkable capability to grow in different substrates; mannanase activity, evidenced by the release of residual oligosaccharides in the cultivation with galactomannan (HPLC-RID, 12.3 mMol); associated to the ability of mannanases expression in a low concentration of inductor conditions (sugarcane bagasse, 0.2%) indicate the high potential for the application of CB10 as a source of enzymes in the production of oligosaccharides from biomass. This capacity might prove to be very valuable for the biorefinery process of pre-biotic precursors and other functional oligosaccharides focused on the food and pharmaceutical industries.…”
Get full text

A custom-made mouthguard reduces head acceleration during soccer heading and prevents acute electrophysiological and cognitive changes in amateur male playersResearch in context by Claire Pitteu, Philippine Lepère, Philippe Poisson, Etienne Guillaud, Emilie Doat, Bertrand Glize, Patrick Dehail, Hélène Cassoudesalle

“…Summary: Background: Repetitive head impacts related to soccer heading might lead to long-term risk of neurodegenerative diseases. …”
Get full text

Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase. by Daniel Barajas, Isabel Fernández de Castro Martín, Judit Pogany, Cristina Risco, Peter D Nagy

“…In this paper, we show an unexpected key role for the conserved Vps4p AAA+ ATPase, whose canonical function is to disassemble the ESCRT complexes and recycle them from the membranes back to the cytosol. …”
Get full text

INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. …”
Get full text

The Effect of Transfusion and Hypoxia on Cells in an in vitro Model of the Neurovascular Unit by A. A. Ivkin, E. V. Grigoriev, E. D. Khilazheva, A. V. Morgun

Get full text

Real-World Effectiveness of Single-Inhaler Triple Treatment Through Assorted Respiratory Outcomes When Switched From Multiple-Inhaler Triple Therapies (RESTART): A Prospective Coho... by Lim H, Kim DH, Hong SH, Shin J, Lee H, Shin K, Ra SW, Lee SJ

“…Despite the effectiveness of multiple inhaler triple therapy (MITT), its complexity often results in poor adherence and suboptimal outcomes. …”
Get full text

Characterization of the mRNA untranslated regions [UTR] of the Trypanosoma cruzi LYT1 isoforms derived by alternative trans-splicing by César Augusto Ramírez, Julián Camilo Casas, María Isabel Ospina, José María Requena, Concepción J. Puerta

“…In trypanosomatids, gene expression is mainly regulated at posttranscriptional level, through mechanisms based on the interaction between RNA Binding Proteins [RBPs] and motifs present in the untranslated regions [UTRs] of them RNAs, which altogether form ribonucleoproteic complexes [RNP] that define the fate of the mRNA. The pre-mRNA derived from the LYT1 gene of Trypanosoma cruzi, is processed by alternative trans-splicing, resulting in different mRNAs which code for the isoforms mLYT1 and kLYT1, proteins having differential expression, cellular location and function. …”
Get full text

Integrating machine-readable user interface requirements into open networked operating rooms by Okan Yilmaz, Dominik Stegemann, Klaus Radermacher, Miriam Lange, Armin Janß

“…This has to be fulfilled by applying recognized standards such as ISO 14971 (RM) and IEC 62366-1 (UE). Addressing the complexity of use cases with multiple network participants requires defining use context, hazardous situations, user profiles, user interfaces, system function contributions, limitations, configurations, and required conditions for safe use. …”
Get full text

Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae. by Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura

“…These results strongly suggest that the host- and virus-derived secretory glycoproteins have overlapping roles in the viral life cycle of Flaviviridae, especially in the maturation of infectious particles, while Erns and NS1 also participate in replication complex formation and viral entry, respectively. Considering the abundant hepatic expression and liver-specific propagation of these apolipoproteins, HCV might have evolved to utilize them in the formation of infectious particles through deletion of a secretory viral glycoprotein gene.…”
Get full text

Prediction of hearing aid cognitive outcomes in age-related hearing loss by Patrice Voss, Zaida Escila Martinez-Moreno, Francois Prévost, Anthony Zeitouni, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Etienne de Villers-Sidani

“…Although the phenomena underlying cognitive decline and dementia are complex, there is growing evidence suggesting that degraded sensory inputs caused by age-related hearing loss may play a central role in accelerating cognitive decline in older individuals. …”
Get full text