Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players by Yidong Zhang, Jiawei Zhu, Ke Hu, Jie Qiu, Fuquan Zhang, Fuquan Zhang

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The Computational Analysis and Phytochemical Screening Targeting Dihydrolipoamide Dehydrogenase (DLD) for Alzheimer's Disease: A Molecular Dynamics Simulation Study by Muhammad Mazhar Fareed

“…Dihydrolipoamide dehydrogenase (dld), and DLD1 are specific chemicals comprised of two enzymes/complexes of protein; pyruvate dehydrogenase and α-ketoglutarate dehydrogenase physiologically related to AD and have a noteworthy function in energy metabolism. …”
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Targeting senescent cells in translational medicine by Marta Paez‐Ribes, Estela González‐Gualda, Gary J Doherty, Daniel Muñoz‐Espín

“…Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. …”
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The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease by Yu-Long Lan, Shuang Zou, Jian-Jiao Chen, Jie Zhao, Shao Li

“…Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. …”
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Sport-Orthopädie by Kraus K, Doyscher R, 3, Schütz E

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Combinations of SNPs related to signal transduction in bipolar disorder. by Pernille Koefoed, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Ingrid Melle, Gert Lykke Møller, Ole Mors, Thomas Werge, Erling Mellerup

“…Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. …”
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Inertial-Based Dual-Task Gait Normalcy Index at Turns: A Potential Novel Gait Biomarker for Early-Stage Parkinson’s Disease by Lin Meng, Xiaofei Zhang, Yu Shi, Xinge Li, Jun Pang, Lei Chen, Xiaodong Zhu, Rui Xu, Dong Ming

“…As one of the main motor indicators of Parkinson’s disease (PD), postural instability and gait disorder (PIGD) might manifest in various but subtle symptoms at early stage resulting in relatively high misdiagnosis rate. …”
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Rett Syndrome: From Bed to Bench by Shih-Ming Weng, Mark E.S. Bailey, Stuart R. Cobb

“…As shown in human studies, Mecp2 mutants also display subtle alterations in neuronal morphology, including smaller cortical neurons with a higher-packing density and reduced dendritic complexity. Neurophysiological studies in Mecp2-mutant mice consistently report alterations in synaptic function, notably, defects in synaptic plasticity. …”
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Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat by Jean Pierre Munyaneza, Minjun Kim, Eunjin Cho, Aera Jang, Hyo Jun Choo, Jun Heon Lee

“…Interestingly, two candidate genes (GPNMB and SFRP1) were reported to regulate the expression of genes known to be involved in fatty acid synthesis, such as the FASN, ACACA, ACLY, ELOVL, and SCD genes. Identification of functional candidate genes for fatty acid profiles might facilitate the selection and breeding of chickens with desirable and healthier fatty acids. …”
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Emic and Etic Perspectives on HR Practice for Managing Human Resource Issues Affected by the Prevalence of Informal Networks in Arab Countries by Sa’ad Ali, David Weir, Munirah Sarhan AlQahtani, Mansour Mrabet

“…The findings shed light on the impact of Wasta on HRM practice on the micro and macro levels, highlighting the complex socio-economic needs for this practice which, whilst they might be beneficial on the micro level in terms of securing employment for job seekers and benefits for organizations in the Wasta exchange process, can also have some substantive negative outcomes in the forms of social and economic exclusion of others outside the Wasta network. …”
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Novel potential biomarkers for predicting childhood caries via metagenomic analysis by Hui Zhang, Hui Zhang, Xiao Zheng, Xiao Zheng, Xiao Zheng, Yongmao Huang, Yongmao Huang, Yuanqiang Zou, Tao Zhang, Maria Alice Repo, Maria Alice Repo, Meixiang Yin, Yang You, Zhuye Jie, Wen-an Xu, Wen-an Xu

“…Additionally, we identified 16 species as the best marker for severe dental caries, achieving an impressive AUC of 0.91.ConclusionThe role of microbiota in dental caries is multifaceted, involving a complex interplay of microbial species and functions. …”
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Adjusting the timing of inseminations to the time lag on luteolysis alerts results in higher conception in dairy cattle by D. Meuwissen, M.J. Gote, R. Meyermans, S. Janssens, I. Adriaens, B. Aernouts

“…ABSTRACT: Dairy cow fertility is a complex trait that depends on the cow's physiological status, the farm's environmental and management conditions, and their interactions. …”
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Evolution of cetacean-specific conserved non-coding elements suggests their role in the limb changes during secondary aquatic adaptation by Zhenhua Zhang, Zhenpeng Yu, Yujie Chong, Yao Liu, Jia Liu, Wenhua Ren, Shixia Xu, Guang Yang

“…Conclusions In summary, our study supports the functional role of CNE sequence divergence and the complex mechanisms underlying limb morphology changes in cetaceans.…”
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Brain Signals of Face Processing as Revealed by Event-Related Potentials by Ela I. Olivares, Jaime Iglesias, Cristina Saavedra, Nelson J. Trujillo-Barreto, Mitchell Valdés-Sosa

“…We analyze the functional significance of different event-related potentials (ERPs) as electrophysiological indices of face perception and face recognition, according to cognitive and neurofunctional models of face processing. …”
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Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal Stem Cell Recruitment by Julia van de Kamp, Willi Jahnen-Dechent, Bjoern Rath, Ruth Knuechel, Sabine Neuss

“…Due to their high self-renewal capacity and excellent differentiation potential in vitro, MSC are ideally suited for regenerative medicine. The complex interactions of MSC with their environment and their influence on the molecular and functional levels are widely studied but not completely understood. …”
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Verifiable secure aggregation scheme for privacy protection in federated learning networks by Wujun Yao, Tanping Zhou, Yiliang Han, Xiaolin Wang

“…Most existing solutions assume a semi-honest system, considering each participant to be honest but curious, which does not align with the complex real-world environment. In reality, servers might act maliciously by tampering with or forging aggregation results, which directly threatens the integrity of global models.. …”
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L’activité réflexive des agents de terrain lors d’un dispositif de formation hybride qui intègre de la réalité virtuelle by Artémis Drakos, Jacques Theureau, Geneviève Filippi, Simon Flandin, Germain Poizat

“…Designed by the researchers and a trainer, this device, known as scenario-inquiry, is intended to help trainees gain an understanding of the spatial and functional characteristics of a complex industrial building, essential knowledge for their future job as field operators. …”
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Combined fMRI and eye-tracking evidence on the neural processing of visual ambiguity in photographic aesthetics by Maria Arioli, Nicola Canessa, Alessandra Gargiulo, Matteo Zardin, Andrea Falini, Alberto Sanna

“…Task-by-stimulus type interaction analyses showed that evaluating ambiguous stimuli was specifically associated with stronger fixation-related activity in the left medial prefrontal cortex, as well as decreased connectivity from this region to its right-hemispheric homologue, possibly supporting in-depth visuospatial analyses of complex visual images. These findings pave the way for future studies addressing the role of visual ambiguity in aesthetic appreciation, as well as the factors that might ease vs. hamper its processing and resolution, and their neural correlates.…”
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Syntactic development and its interplay with word processing and working memory in preschoolers’ brain: An fNIRS longitudinal study by Dongsu Yan, Tongfu Fang, Wei He, Min Xu

“…We employed functional near-infrared spectroscopy to examine among preschool children (N=50, Mage=61.5 months) the neural activation associated with processing sentences of varying syntactic complexities, as well as tasks assessing word comprehension and working memory. …”
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Dystonic Movement Disorder as Symptom of Catatonia in Autism Spectrum Disorder by Maria Pia Riccio, Rosamaria Siracusano, Ilaria d’Alessandro, Maria Marino, Carmela Bravaccio

“…Moreover, recognizing symptoms in ASD patients with medium-low functioning might be difficult. Literature on this argument is poor, especially for children. …”
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