Unraveling the source of corrosive microorganisms from fracturing water to flowback water in shale gas field: evidence from gene sequencing and corrosion tests by Yanran Wang, Shaomu Wen, Shibo Zhang, Yongfan Tang, Xi Yuan, Fang Guan, Fang Guan, Jizhou Duan

“…As an insidious and often underestimated phenomenon, microbially influenced corrosion (MIC) poses a significant threat to the integrity and longevity of oil and gas pipelines. However, the complex corrosive microorganisms, that might induce MIC in underground pipelines, might be introduced by the fracturing water during the production period, or they may also exist in the native corrosive microbial community underground. …”
Get full text

An Insight on Gut Flora, Colorectal Cancer Mechanism, and Treatment Strategies by Rajendra Kumar, Ashmeen Kaur, Divyanshu Rajput

“…The microbiota in the stomach functions like an actual organ. To maintain gut homeostasis, the digestive tract’s symbiotic relationships with the local microorganisms are crucial. …”
Get full text

Alzheimer's Disease: Another Target for Heparin Therapy by Luigi Bergamaschini, Emanuela Rossi, Carlo Vergani, Maria Grazia De Simoni

“…The complexity of AD pathology provides numerous potential targets for therapeutic interventions. …”
Get full text

Dynamic regulation of neutrophil immunometabolism by platelet-derived metabolites by Manuel Alejandro Mosso-Pani, Manuel Alejandro Mosso-Pani, Dante Barreda, Ma. Isabel Salazar

“…Additionally, platelets induce metabolic reprogramming in neutrophils, affecting glycolysis and mitochondrial pathways, while also shaping the immune microenvironment by modulating other immune cells, such as T and B cells. Understanding this complex crosstalk between platelets and neutrophils—two of the most abundant cell types in the bloodstream—might reveal new therapeutic opportunities to regulate immune responses in inflammatory and immune-mediated diseases.…”
Get full text

BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis by Yijin Chen, Dawei Huo, Ye Meng, Jie Zhang, Mengmeng Huang, Qian Luo, Yulin Xu, Haiqiong Zheng, Yingli Han, Xiangjun Zeng, Yanjuan Liu, Yunfei Liu, Rui Wen, Delin Kong, Ruxiu Tie, Shanshan Pei, Nan Liu, Pengxu Qian, He Huang, Meng Zhang

“…Besides, we clarify RhoB’s activity and function during terminal erythropoiesis. BRD4 inhibition might be a simple method to promote in vitro blood cell production, and a candidate therapeutic target for diseases leading to dyserythropoiesis such as myelodysplastic syndromes.…”
Get full text

EXPRESSION OF GENES ENCODING IMMUNOPROTEASOME SUBUNITS INDUCIBLE BY MACROPHAGES INFECTED WITH M. bovis BGC AND M. Tuberculosis H37RV by S. N. Andreevskaya, T. G. Smirnova, A. V. Timofeev, E. E. Larionova, L. N. Chernousova

“…It was assumed that the inhibited transcription of this subunit, when inoculated with the virulent M. tuberculosis strain, might lead to the blocked assembly of the whole immunoproteasome and to its reduced functional activity. …”
Get full text

Throwing Stick to Spear Thrower - Study of Ethnographic Artefacts and Experimentation by Luc Bordes

“…Indeed, some traditional Aboriginal hooked throwing sticks from Coopers Creek might be a trace of a prehistoric throwing stick/spear thrower technological complex which has disappeared to be replaced by true specialised spear throwers from New Guinea, rendering them obsolete. …”
Get full text

Nanosensors for Exhaled Breath Condensate: Explored Models, Analytes, and Prospects by Esther Ghanem

“…Nonetheless, conventional EBC screening methods are complex and require high operational costs and expertise. …”
Get full text

Identification of Gene Targets for the Sprouting Inhibitor CIPC by Thomas M. Grand, James K. Pitman, Alexander L. Williams, Lisa M. Smith, Andrew J. Fleming

“…This approach led to the identification of a component of the augmin complex (a core player in mitosis) as a potential target for CIPC.…”
Get full text

Beyond awareness: the binding of reflexive mechanisms with the conscious mind: a perspective from default space theory by Ravinder Jerath, Connor Beveridge

“…How do reflexes operate so quickly with so much multimodal information on the environment? How might unconscious processes help reveal the nature of consciousness? …”
Get full text

Environmental drivers of the resistome across the Baltic Sea by Joeselle M. Serrana, Francisco J. A. Nascimento, Benoît Dessirier, Elias Broman, Malte Posselt

“…Furthermore, our analysis suggests that microbial community composition and mobile genetic elements might be crucial in shaping ARG diversity and composition. …”
Get full text

What Lies Inside a Dead Coral: Diversity of Reef-Associated Cryptic Crustacean (Crabs: Anomura and Brachyura) from Different Habitat Characteristics in Tidung Islands, Indonesia by Satya Pratama Atmaja, Prakas Santoso, Muhamad Gilang Arindra Putra, Fadel Muhammad, Wiwid Andriyani Lestariningsih, Beginer Subhan, Hawis Madduppa

“… • Different characteristics and complexity of coral habitat affect the dynamics of cryptic crustacean communities   Abstract   Recent studies have been widely carried out on the important role and ecological function of coral reefs. …”
Get full text

Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in an Ex vivo skin model by Giulia Zivelonghi, Luca Melotti, Anna Carolo, Andrea Venerando, Margherita Roncoroni, Giordana Martinelli, Lisa Maccatrozzo, Stefania Marzorati, Michela Sugni, Marco Patruno

“…IntroductionThe skin is often exposed to harmful stimuli that might compromise its integrity and functionality. …”
Get full text

Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis by Fereshteh Ahmadinejad, Seyed Javad Mowla, Mohammad-Amin Honardoost, Mostafa Gholami Arjenaki, Mohammad Moazeni-Bistgani, Soleyman Kheiri, Hossein Teimori

“…These findings suggest that miR-218 expression profiling might be clinically applicable as a prognostic biomarker in breast cancer. …”
Get full text

Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies by M. Sicorello, J. Herzog, T.D. Wager, G. Ende, M. Müller-Engelmann, S.C. Herpertz, M. Bohus, C. Schmahl, C. Paret, I. Niedtfeld

Get full text

Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
Get full text

Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay by Shishir Singh, Shishir Singh, Shishir Singh, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Aura María Bastidas Quintero, Aura María Bastidas Quintero, Florence Melbert, Florence Melbert, Klaus Pfeffer, Daniel Degrandi, Tobias Steinfeldt, Tobias Steinfeldt

“…Toxoplasma gondii (T. gondii) virulence in mice depends on different multiprotein complexes that assemble at the parasitophorous vacuole membrane (PVM) of the parasite. …”
Get full text

Model order reduction for left ventricular mechanics via congruency training. by Paolo Di Achille, Jaimit Parikh, Svyatoslav Khamzin, Olga Solovyova, James Kozloski, Viatcheslav Gurev

“…While finite element models of the heart can naturally account for patient-specific anatomies reconstructed from medical images, optimizing the many other parameters driving simulated cardiac functions is challenging due to computational complexity. …”
Get full text

Monocephalus dipygus in a 4-month-old mixed-breed puppy: clinical, radiographic, ultrasonographic, karyotyping and surgical intervention by Lorena Elizabeth Chalco-Torres, Ana Elizabeth Guerrero López, Mauro Nirchio Tursellino

“…Notably, since each bladder was independently connected to a kidney, surgical intervention in the genitourinary system was avoided to prevent potential impairment of urinary function. This case highlights the complexity of congenital anomalies in canines and emphasizes the importance of a multidisciplinary approach to their diagnosis and management.…”
Get full text

Exploring Therapists’ Approaches to Treating Eating Disorders to Inform User-Centric App Design: Web-Based Interview Study by Pamela Carien Thomas, Pippa Bark, Sarah Rowe

“…Therapists dealing with complex ED issues went beyond traditional CBT using additional therapeutic techniques and a flexible, person-centered approach to treatment. …”
Get full text