Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism by Leyre Merino-Galán, Marta Zamarbide, Arantzazu Belloso-Iguerategui, Marta C. Alonso-Moreno, Belén Gago, Alejandro Reinares-Sebastián, Javier Blesa, Dani Dumitriu, Ana Quiroga-Varela, María Cruz Rodríguez-Oroz

“…In conclusion, impaired striatal dopaminergic neurotransmisson diminishes striatal synaptic plasticity, which can be partially restored through complex structural changes in striatal spines. These adaptations might represent fundamental homeostatic mechanisms regulating synaptic function during the premotor stage of Parkinson’s disease.…”
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Chronic active Epstein–Barr Virus infection in a teenage girl with suspect autoimmune Hepatitis by Wen-Yu Tseng, Shiu-Feng Huang, Chao-Yi Wu, Shih-Hsiang Chen, Chien-Chang Chen

“…Abstract Background The pathogenesis of chronic active Epstein–Barr virus (EBV) disease (CAEBV) is complex, involving infection, inflammation, and in some cases malignancy. …”
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Genome-Wide Ultrabithorax Binding Analysis Reveals Highly Targeted Genomic Loci at Developmental Regulators and a Potential Connection to Polycomb-Mediated Regulation. by Daria Shlyueva, Antonio C A Meireles-Filho, Michaela Pagani, Alexander Stark

“…We observed densely clustered Ubx binding sites at 12 extended genomic loci that included ANTP-C, BX-C, Polycomb complex genes, and other regulators and the clustered binding sites were frequently active enhancers. …”
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Diagnosis and management of a giant retroperitoneal hematoma compressing the femoral nerve, following an ultrasound-guided lumbar sympathetic block: a case report by Yan Bai, Xinqiao Zhou, Lingqing Zeng, Xiaokai Zhou, Zhuqing Rao, Cunming Liu, Yinbing Pan, Xiaodi Sun

“…Abstract Background The lumbar sympathetic nerve block stands as a pivotal approach in managing complex regional pain syndrome (CRPS) in the lower limbs. …”
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Metal oxides on the frontlines: Antimicrobial activity in plant-derived biometallic nanoparticles by Krishnan Anbarasu, Sathishkumar Kuppusamy, Devi Okram Ricky, Agrawal Smita, Debnath Abhijit, Arasu Mariadhas Valan, Sundaram Thanigaivel, Subramanian Kumaran, Karunakaran Rohini

“…The work carefully evaluates the processes behind this dual function, providing insight into the complex interactions between metal oxides and chemicals originating from plants. …”
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Renal Artery Blood Flow and Surface Parenchymal Perfusion During Renal Artery Endoshunting in a Porcine Model by Johan Millinger, Marcus Langenskiöld, Andreas Nygren, Klas Österberg, Joakim Nordanstig

“…This suggests that endoshunting to the kidney using an endoshunt system might be a promising strategy to preserve renal function when temporary interruption of native renal artery blood flow is needed during complex vascular surgical repairs involving the renal arteries.…”
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A fungal ubiquitin ligase and arrestin binding partner contribute to pathogenesis and survival during cellular stress by Lukas M. du Plooy, Calla L. Telzrow, Connie B. Nichols, Corinna Probst, Natalia Castro-Lopez, Floyd L. Wormley, J. Andrew Alspaugh

“…We identified a complex of proteins responsible for adding ubiquitin groups to fungal proteins, and this complex is required for virulence. …”
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Evaluating the Potential Use of Wearable Fitness Devices as a Measure of Outcomes in Orthopaedics by Jordan Henderson BS, Santiago Logan-Baca BS, Sara Kisiel BS, Fadi Muheidat PhD, David Jaffe MD

“…Despite objective measurements of activity consistency, patient-reported scores on factors like daily living and sport were nuanced, underscoring the complex interplay between physical functioning and subjective experience of pain. …”
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High‐order combination effects and biological robustness by Joseph Lehár, Andrew Krueger, Grant Zimmermann, Alexis Borisy

“…Biological systems are also complex, being organized into many functional modules that communicate through interlocking pathways and feedback mechanisms. …”
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Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia by Patrick Oeckl, Petra Steinacker, Markus Otto, Steffen Halbgebauer, MHD Rami Al Shweiki, Samir Abu-Rumeileh, Naguib Mechawar, Carlos Schönfeldt-Lecuona, Lorenzo Barba, Leonie Werner, Alexander Tarabuko, Ilyas Al-Ali, Christopher R Pryce, Nadia Cattane, Giulia Poggi, Heiko Graf, Henning Großkopf, Laura Meier, Hugh Marston, Klaus D Bornemann, Bastian Hengerer, Karin M Danzer

“…We propose that CSF SNAP-25 level might represent an integrated readout of reduced synaptic function, rather than of synaptic degeneration, in MDD. …”
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Prescriptive Predictors of Mindfulness Ecological Momentary Intervention for Social Anxiety Disorder: Machine Learning Analysis of Randomized Controlled Trial Data by Nur Hani Zainal, Hui Han Tan, Ryan Yee Shiun Hong, Michelle Gayle Newman

“…Nevertheless, widely used classical regression methods might not optimally capture complex nonlinear associations and interactions. …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…Abstract The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. …”
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On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa by Corinna Benz, Maximilian W. D. Raas, Pragya Tripathi, Drahomíra Faktorová, Eelco C. Tromer, Bungo Akiyoshi, Julius Lukeš

“…Here, we employed deep homology detection protocols using profile-versus-profile Hidden Markov Model searches and AlphaFold-based structural comparisons to detect homologies that might have been previously missed. Interestingly, we still could not detect orthologs for most of the kinetoplastid or canonical kinetochore subunits with few exceptions including a putative centromere-specific histone H3 variant (cenH3/CENP-A), the spindle checkpoint protein Mad2, the chromosomal passenger complex members Aurora and INCENP, and broadly conserved proteins like CLK kinase and the meiotic synaptonemal complex proteins SYCP2/3 that also function at kinetoplastid kinetochores. …”
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Step-by-step: Intra-arterial renal hypothermia during robot-assisted partial nephrectomy by Joris Vangeneugden, Pieter De Backer, Camille Berquin, Saar Vermijs, Peter Dekuyper, Alexandre Mottrie, Charlotte Debbaut, Thierry Quackels, Charles Van Praet, Karel Decaestecker

“…Objective: Renal hypothermia, which can be achieved through several techniques, might allow for longer clamping times in complex robot-assisted partial nephrectomy (RAPN). …”
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Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure by Minfei Qian, Qixuan Wang, Zhongying Wang, Qingping Ma, Xueling Wang, Kun Han, Hao Wu, Zhiwu Huang

“…Notably, repeated moderate-intensity noise exposures (97 and 100 dB SPL) not only caused hearing threshold shifts and the inner hair cell ribbon synaptopathy but also impaired MOC efferent synapses, which might contribute to complex patterns of damages on cochlear function and morphology. …”
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Classification of ROI-based fMRI data in short-term memory tasks using discriminant analysis and neural networks by Magdalena Fafrowicz, Marcin Tutajewski, Igor Sieradzki, Jeremi K. Ochab, Jeremi K. Ochab, Anna Ceglarek-Sroka, Koryna Lewandowska, Tadeusz Marek, Barbara Sikora-Wachowicz, Igor T. Podolak, Paweł Oświęcimka, Paweł Oświęcimka, Paweł Oświęcimka

“…In recent years, machine learning methods have been widely used to detect connections between regions of interest (ROIs) involved in cognitive functions, as measured by the fMRI technique. However, it's essential to match the type of learning method to the problem type, and extracting the information about the most important ROI connections might be challenging. …”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Conclusions These findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo +/+ inherit identical genetic material as WT-Control, their development might be shaped by the parent’s physiology, behavior, or metabolic state influenced by their Kmo genotype, leading to phenotypic sex-specific differences in offspring.…”
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Insights on Natural Membrane Characterization for the Rational Design of Biomimetic Drug Delivery Systems by Daniela Donghia, Sara Baldassari, Giuliana Drava, Giorgia Ailuno, Gabriele Caviglioli

“…They are composed of a complex lipid bilayer embedded with proteins, allowing them to perform multiple functions like maintaining the cell structure, regulating which substances enter or leave the cell, and intercellular communication. …”
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Reprogramming of H3K27me3 is critical for acquisition of pluripotency from cultured Arabidopsis tissues. by Chongsheng He, Xiaofan Chen, Hai Huang, Lin Xu

“…The Polycomb Repressive Complex 2 (PRC2) is known to function in establishing H3K27me3. …”
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A Lightweight YOLOv8s Algorithm for Ceiling Fan Blade Defect Detection With Optimized Pruning and Knowledge Distillation by Qinyuan Huang, Chen Fan, Yuqi Sun, Jiaxiong Huang, Wengziyang Jiang

“…The proposed hybrid loss function promotes sufficient knowledge transfer of intermediate and output features from the teacher to the student network, thus preserving defect identification capabilities that might otherwise degrade through knowledge distillation. …”
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