A neural circuit covarying with social hierarchy in macaques. by MaryAnn P Noonan, Jerome Sallet, Rogier B Mars, Franz X Neubert, Jill X O'Reilly, Jesper L Andersson, Anna S Mitchell, Andrew H Bell, Karla L Miller, Matthew F S Rushworth

“…To examine this possibility we used magnetic resonance imaging (MRI), which affords the taking of quantitative measurements noninvasively, both of brain structure and of brain function, across many regions simultaneously. We carried out a series of tests of structural and functional MRI (fMRI) data in 25 group-living macaques. …”
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Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions by Gianmarco Gualtieri, Emanuele Liborio Citriniti, Roberta Rocca, Valentina Arciuolo, Jussara Amato, Antonio Randazzo, Stefano Alcaro

“…Modulating their stability and function holds promise for treating diseases like cancer. …”
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Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions. by Pornchai Anuntasomboon, Suradej Siripattanapipong, Sasimanas Unajak, Kiattawee Choowongkomon, Richard Burchmore, Saovanee Leelayoova, Mathirut Mungthin, Teerasak E-Kobon

“…The intricate interplay between SNPs and gene expression alterations might underscore the complex regulatory networks underlying the AmB resistance of L. orientalis strain PCM2.…”
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The Interaction among Microbiota, Immunity, and Genetic and Dietary Factors Is the Condicio Sine Qua Non Celiac Disease Can Develop by D. Pagliari, R. Urgesi, S. Frosali, M. E. Riccioni, E. E. Newton, R. Landolfi, F. Pandolfi, R. Cianci

“…Celiac disease (CD) is an immune-mediated enteropathy, triggered by dietary wheat gluten and similar proteins of barley and rye in genetically susceptible individuals. This is a complex disorder involving both environmental and immune-genetic factors. …”
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Resolving structural variability in network models and the brain. by Florian Klimm, Danielle S Bassett, Jean M Carlson, Peter J Mucha

“…Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. …”
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Membranoproliferative Glomerulonephritis and X-Linked Agammaglobulinemia: An Uncommon Association by Vasco Lavrador, Filipa Correia, Rita Sampaio, Cristina Cândido, Maria Sameiro-Faria, Laura Marques, Conceição Mota

“…He presented with pneumonia, macroscopic hematuria, nephrotic proteinuria, hypoalbuminemia, and hypercholesterolemia with normal renal function and serum complement levels. Renal histology showed immune complex mediated MPGN. …”
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ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics. by Jamie S Lin, Jin Seok Jeon, Qingfeng Fan, Hetty N Wong, Matthew B Palmer, Lawrence B Holzman

“…In the nephrotoxic serum nephritis model, which induced immune-complex mediated injury, ARF6_PodKO mice exhibited aggravated proteinuria. …”
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Exploring Basic Psychological Need Satisfaction and Relationship Quality as Protective Factors of Mental Well-Being During the COVID-19 Pandemic by Barbara Horvát, Tamás Martos, Claudia Chiarolanza, Viola Sallay, Ashley K. Randall

“…While better relationship experiences might even heighten perceived stress during a global crisis, they simultaneously function as protective factors for overall mental health.…”
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Military experience predicts military multitasking better than laboratory measures in officer cadets by Yannik Hilla, Maximilian Stefani, Elisabeth V. C. Friedrich, Wolfgang Mack

“…We discuss the role of learned task representations in this regard and conclude that it might be more reasonable to investigate cognitive functions as co-variates of associations between military characteristics (e.g., military service duration) and military performance in future research than to focus on laboratory measures as predictors of military performance.…”
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Comparative analyses of the gut microbiome of two sympatric rodent species, Myodes rufocanus and Apodemus peninsulae, in northeast China based on metagenome sequencing by Jing Cao, Shengze Wang, Ruobing Ding, Yijia Liu, Baodong Yuan

“…The gut microbiota of A. peninsulae and M. rufocanus differed marginally in functional profiles, specifically in the breakdown of complex carbohydrates, which might reflect their distinct food preferences albeit both being herbivores with a substantial dietary overlap. …”
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Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells. by Xiaoting Fan, Qian Zhang, Chao You, Yuanxia Qian, Jing Gao, Peng Liu, Huiqing Chen, Huifang Song, Yan Chen, Keping Chen, Yajing Zhou

“…In vitro pull down and co-immunoprecipitation assays show that the μ-calpain binds to p12 through the interaction of μ-calpain with Pol δ other three subunits, not p12 itself, and PCNA, implying that the proteolysis of p12 by μ-calpain might be through a Pol δ4/PCNA complex. The p12 cleavage sites by μ-calpain are further determined as the location within a 16-amino acids peptide 28-43 by in vitro cleavage assays. …”
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Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer by Panchalee Bhaumik, Chandrasekhar Gopalakrishnan, Balu Kamaraj, Rituraj Purohit

“…Further we performed expression analysis to shed light on the potential tissues that might be affected by mutation, enrichment analysis to find the metabolic functions of the gene, and network analysis to highlight the important interactions of cancer causing genes with other genes to provide insight that complex network will be disturbed upon mutation. …”
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Neural Networks vs. Regression: A Comparative Analysis in Medical Data Processing by Minodora ANDOR, Gheorghe Ioan MIHALAŞ

“…The risk of post-COVID-19 type 2 diabetes (glycaemia at 4 and at 12 months post-COVID as function of metabolic parameters) was predicted using both linear regression and FFNN. …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Background For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. …”
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Research progress of chondroitin sulfate and chondroitin sulfate proteoglycan in diabetic kidney disease by ZHANG Min, HU Chun, WU Xiao-yan

“…Chondroitin sulfate/chondroitin sulfate proteoglycan(CS/CSPG) is an essential component of ECM, including a large family of biological active molecules with complex structures and various functions. They play important functional and regulatory roles in physiology and pathology. …”
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Bacterial wilt resistance gene Slmlo1/6 mutants in tomato created by CRISPR/Cas9 technology by SHI Jianlei1, 2, XIONG Zili1, SU Shiwen1, FU Cunnian1, ZAI Wenshan1*

“…The pathogenic species are complex and tend to have a variation, while mlo caused by the recessive mutation of MLO genes has a broad-spectrum resistance. …”
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Optimizing dsRNA sequences for RNAi in pest control and research with the dsRIP web platform by Doga Cedden, Gözde Güney, Michael Rostás, Gregor Bucher

“…Abstract Background RNA interference (RNAi) is a tool for studying gene function and has emerged as a promising eco-friendly alternative to chemical pesticides. …”
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Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans. by Yan Lv, X Y He, Dongguo Li, Tao Liu, G Q Wen, Junfa Li

“…Gene Ontology (GO) functional annotation, Protein-Protein Interaction (PPI) network, "Molecular Complex Detection" (MCODE) modules, CytoNCA (cytoscape network centrality analysis) essential genes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway interrelation analysis were performed.…”
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Phlegmasia Cerulea Dolens in a Patient with Breast Cancer and Inferior Vena Cava Hypoplasia by A. Bianchi, S. Pozza, L. Giovannacci, Jos. C. van den Berg

“…This case report shows how a hybrid approach might be successful. It also shows how rare pathologies can combine to create a life- and limb-threatening condition. …”
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Impact of Coconut Oil and Its Bioactive Metabolites in Alzheimer’s Disease and Dementia: A Systematic Review and Meta-Analysis by Duaa Bafail, Abrar Bafail, Norah Alshehri, Noura Hamdi Alhalees, Ahmad Bajarwan

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