Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-anal... by Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun, Zhong Wang

“…GBM multi-omics data from public and in-house cohorts validated that CD44 and SURF4 might be synthetic lethal partners of loss-of-function tumor suppressor genes. …”
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Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism by Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li

“…These results suggest that chronic oral SFN-I protects against DCM by mitigating overall metabolic dysregulation and inhibiting cardiolipotoxicity. The latter might involve controlling cardiac fatty acid metabolism and improving mitochondrial function, rather than promoting glucose metabolism.…”
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Presentation and physical therapy management using a neuroplasticity approach for patients with hypermobility-related upper cervical instability: a brief report by Susan Chalela, Susan Chalela, Leslie N. Russek, Leslie N. Russek

“…One patient returned to full function with intermittent flares that he was able to manage. …”
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Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis by Liang Zhao, Hongling Jia, Zhikai Xiahou, Li Ren, Yanbing Song, Hao Xu, Zhihan Wang, Jin Xing

“…We found that ECs might play a role in MEN progression and further classified them into four subpopulations. …”
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Developing approaches to treating arterial hypertension in regard to possible pathways of angiotensin II synthesis by N. M. Chikhladze, N. V. Lebedeva, L. A. Belova, G. N. Litonova, E. B. Yarovaya, I. E. Chazova

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The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review by Siobhan C. Murray, Claire McNamara, Anna V. Chatzi

“…As clinicians' ethical considerations and fears emerged from the literature, nurses' special role has not been sufficiently supported. Complex care requires facilitation by multidisciplinary teams and education around the device's function regarding EOL issues. …”
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On the Analysis of the Contact Conditions in Temporomandibular Joint Prostheses by B. Gonzalez-Perez-Somarriba, G. Centeno, C. Vallellano, L. M. Gonzalez-Perez

“…Although temporomandibular joint replacements (TMJRs) are expected to accomplish their function during a number of years, they might actually fail and need to be replaced. …”
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Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder by Weipu Mao, Tracy Zhang, Huan Chen, Sagar Barge, Zongwei Wang, Aria Olumi, Seth Alper, Weiqun Yu

“…The urothelial-localized ACVR2B/ACVR1B receptor complex suggests a role of activin signaling in urothelial function. …”
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Genomic insights into the plasmidome of non-tuberculous mycobacteria by Margo Diricks, Florian P. Maurer, Viola Dreyer, Ivan Barilar, Christian Utpatel, Matthias Merker, Nils Wetzstein, Stefan Niemann

“…Furthermore, we analyzed 3755 draft genome assemblies from over 200 NTM species and 5415 short-read sequence datasets from six clinically relevant NTM species or complexes including M. abscessus, M. avium complex, M. ulcerans complex and M. kansasii complex, for the presence of these plasmids. …”
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The Porphinoids - Versatile Biological Catalyst Molecules by Bernhard Kräutler

“… The natural porphinoids, such as the iron complex heme, the magnesium complex chlorophyll a, the nickel complex coenzyme F430, and the (corrinoid) cobalt complex coenzyme B12 play central roles in all spheres of life, e.g. as cofactors for oxygen or electron transport, for collecting light and transforming energy, and as catalysts in biosynthesis. – How the porphinoid structures developed in nature, how their often unique properties arise from special interactions between the bound metal ions and the macrocyclic ligands, and to which particular chemical reactivities and modes of action the porphinoids owe their specific biological functions – these are central questions to this topic. …”
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Hybrid virtual screening and molecular dynamics approach for identification of allosteric modulator of EAAT2 by Chennu Manisha, Nagarjuna Palathoti, Jagdish Chand, Akey Krishna Swaroop, Jubie Selvaraj, B.R. Prashantha Kumar, Prisil Naveentha X, Brindha Durairaj, Antony Justin

“…Therefore, compounds that enhance EAAT2 function by reducing oxidative stress and excitotoxicity might be neuroprotective. …”
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A cell cycle timer for asymmetric spindle positioning. by Erin K McCarthy Campbell, Adam D Werts, Bob Goldstein

“…We found that reducing the function of the proteasome, the APC, or Cdc20/Fizzy delayed spindle displacement. …”
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The double role of GABAergic system in systemic tumors: an updated review by Xueyang Yang, Qianhe Zu, Luxuan Wang, Chunhui Li, Lijian Zhang, Lijian Zhang

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Exercise in atherosclerosis: its beneficial effects and underlying mechanism by Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Meng-ting Yin, Liang Guo, Liang Guo, Liang Guo, Liang Guo

“…Atherosclerosis represents a complex interplay of inflammatory and metabolic processes, in which oxidative stress, endothelial inflammation, the phenotypic transition of smooth muscle cells (SMCs), and the conversion of macrophages into foam cells are involved. …”
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Combination of the ranking method and time reversal asymmetry for evaluating the quality of translations: a case study on passages from works by Edgar Allan Poe and Kenzaburo Oe by Kazuya Hayata

“…The complex systems approach to natural language has become a fascinating topic that is closely related to physics and linguistics. …”
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Inteligência biológica versus inteligência artificial: uma abordagem crítica Biologic intelligence versus artificial intelligence: a critical approach by Wilson Luiz Sanvito

“…In the present paper it is stressed that brain/mind complex constitutes a monolithic system that functions with emergent properties at several levels of hierarchical organization. …”
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A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. by Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T Neil Dear

“…This is the first demonstration that a defect in a gene involved in mitochondrial remodelling can result in cardiomyopathy, showing that the function of this gene is needed for the maintenance of normal cellular function in a relatively tissue-specific manner. …”
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QUALITY OF LIFE EVALUATION IN RECIPIENTS AFTER KIDNEY TRANSPLANTATION by E. P. Volynchik, M. M. Kaabak, I. I. Stenina, E. M. Balakirev, V. A. Goryainov

“…Obviously, quality of life of recipients with functioning transplanted kidney is undoubtedly of scientific interest and needs further extended studies that might contribute to better interpretation of long-term results after kidney transplantation.…”
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Integrating proteomic and phosphoproteomic profiles provide new insights into ABA-dependent signal regulation network in maize response to heat stress by Yanpei Liu, Yulong Zhao, Haiying Zhan, Shanshan Lv, Yanmin Luo, Wei Wang, Xiuli Hu

“…Among them, heat shock proteins (17 DEPs and 3 DEPPs), transcription factors (9 DEPs and 27 DEPPs), ubiquitin-proteasome system components (1 DEP and 6 DEPPs), translation-related to proteins (23 DEPs and 22 DEPPs) and defensive proteins (12 DEP and 24 DEPPs) were identified, indicating that chaperon protein function, protein turnover, and defense system might be the key ABA-mediated processes in maize HS response. …”
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C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages by Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li

“…Our article found C5aR2 deficiency lessened C5aR1 distribution and expression in neutrophils and macrophages with different functions, indicating C5aR2 might function differently in different cells.…”
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