Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis by Yinyi Xiong, Li Li, Xiaorong Zhang

“…In contrast, it is capable of mediating multifaced neurological functions which are more complex than those of Drosophila Dscam. …”
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Chromatin binding and silencing: Two roles of the same protein Lem2 by Ramón Ramos Barrales, Sigurd Braun

“…This further unveils a complex function of this protein at the interface between the nuclear periphery and silent chromatin, which might be preserved among the other members of this conserved family of LEM proteins.…”
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Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification by Kartik Balachandran, Philippe Sucosky, Ajit P. Yoganathan

“…Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. …”
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A conversation on academic freedom and freedom of expression at the university by Robert C. Post, Jordi Pujol

“…At their best, universities function as ‘disciplinary communities’ who must act in professionally competent ways. …”
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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases by Núria Mach

“…Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. …”
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The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair. by Aymeric P Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M J Lilley, Shawn Ahmed, Anton Gartner

“…Furthermore, GEN-1 acts redundantly with the 9-1-1 complex to ensure genome stability. Our study suggests that GEN-1 might act as a dual function Holliday junction resolvase that may coordinate DNA damage signaling with a late step in DNA double-strand break repair.…”
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Endocrine consequences of childhood obesity: a narrative review by Maroun Badr, Ghazwa El-Rabaa, Marianne Freiha, Andrzej Kędzia, Elżbieta Niechciał

“…If insulin resistance is not adequately managed, it might precipitate type 2 diabetes. Another common finding among children with obesity is thyroid dysfunction. …”
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Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases by Meng Zhang, Jin Wei, Chang He, Liutao Sui, Chucheng Jiao, Xiaoyan Zhu, Xudong Pan

“…Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. …”
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A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder by Adriano Alberti, Willians Fernando Vieira, David Richer Araujo Coelho, Daniel Fernandes Martins

“…The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. …”
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Socio‑Economic Determinants of Construction Sector Development by Florian Gerth, Martin O’Brien, Karol S. Sikora

“…To do this, the study conducts a combination of regression analyses, Ordinary Least Squares in conjunction with Methods-of-Moments, while applying rigor to guarantee compliance with the CLR function assumptions. We find that the link between economic development and activity in construction is more complex than previously believed, with the role of the construction industry changing during economic development. …”
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Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty by Hendri Saputra, Sutanto Soehodho

“…Current problems of concern in aviation safety management involve a series of constraints, evaluation methods, and complex decision-making processes. Uncertainty in these problems adds complexity. …”
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Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart by Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal, Sandhya L. Sitasawad

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VPS35-Retromer: Multifunctional Roles in Various Biological Processes – A Focus on Neurodegenerative Diseases and Cancer by Fan X, Xie Y, Cao S, Zhu L, Wang X

“…As an integral component of the Retromer complex, VPS35 selectively recognizes and retrogradely transports membrane protein receptors to the trans-Golgi network, thereby preventing the degradation of transmembrane proteins by lysosomes after they have fulfilled their physiological functions, and facilitating their continued activity. …”
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Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis by Robert Gross, Jennifer Davis, Julie Roth, Henry Querfurth

“…We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. …”
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Transition metal abundance as a key parameter for the search of Life in the Universe by Giovanni Covone, Donato Giovannelli

“…The availability of these transition metals is not uniform in the Universe, and it is a function of the distribution (in time and space) of complex dynamics. …”
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Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. by Jun-Yi Zhu, Natalia Vereshchagina, Vrinda Sreekumar, Lena F Burbulla, Ana C Costa, Katharina J Daub, Dirk Woitalla, L Miguel Martins, Rejko Krüger, Tobias M Rasse

“…Given the specificity of the observed defects, we are confident that the loss-of-mortalin model presented in this study will be useful for further dissection of the complex network of pathways that underlie the development of mitochondrial parkinsonism.…”
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Peripartum Cardiomyopathy-Induced Cardiogenic Shock Causing Hypoxic-Ischemic Encephalopathy in a COVID-19 Patient by Minh Khoi Le, Thanh Hieu Nguyen

“…The etiology of PPCM is not fully elucidated and is probably multifactorial, and viral infection might play some role. It has been documented that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly invades the cardiomyocytes and most commonly damages this vital organ via complex systemic devastating mechanisms. …”
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Relationship between reduced serum ceruloplasmin levels and executive dysfunction in hospitalized schizophrenia patients by Dan Kuang, Hongkai Wei, Wei Qin

“…ObjectiveExecutive dysfunction is a widespread and complex manifestation in schizophrenia, significantly impairing patients’ cognitive and functional outcomes. …”
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Exercise: a non-drug strategy of NK cell activation by Huixin Pan, Rui Meng, Zixuan Jia, Jing Zhang, Wen Ma, Youhan Liu, Qinglu Wang, Qiaoqiao Li

“…So far, it is widely believed that moderate exercise can significantly enhance the proliferation and activity of NK cells, strengthening immune function. However, the impact of exercise on NK cells is a dynamic and complex process. …”
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The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance by Haiqing Jia, Jing Wei, Wei Zheng, Zhuo Li

“…Autophagy, an evolutionarily preserved cellular mechanism for degradation and recycling, has a complex function in cancer by aiding cell survival during stress and preserving balance by eliminating damaged organelles and proteins. …”
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