CT IMAGING IN THE ELDERLY: ADDRESSING CHALLENGES AND ENHANCING DIAGNOSTIC ACCURACY by Uliana Pidvalna, Ihor Romaniuk, Anna Voitovych, Marianna Mirchuk

“…Educating medical staff on the needs of elderly patients ensures better comfort and care. Implementing complex solutions for optimizing CT imaging might improve the diagnostic outcomes and patient experience.…”
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Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis by Ran Guo, Hao Wang, Na Cui

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Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. by Enrica San Pietro, Mariagrazia Capestrano, Elena V Polishchuk, Alessio DiPentima, Alvar Trucco, Pasquale Zizza, Stefania Mariggiò, Teodoro Pulvirenti, Michele Sallese, Stefano Tete, Alexander A Mironov, Christina C Leslie, Daniela Corda, Alberto Luini, Roman S Polishchuk

“…Here, we examine the mechanisms of generation and the function of these tubules. In principle, tubule formation might depend on several protein- and/or lipid-based mechanisms. …”
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What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus? by Hujun Shen, Hui Sun, Guohui Li

“…Many experimental studies of the kinetics of nucleotide incorporation by RNA and DNA polymerases suggest that each nucleotide incorporation cycle basically consists of six sequential steps: (1) an incoming nucleotide binds to the polymerase-primer/template complex; (2) the ternary complex (nucleotide-polymerase-primer/template) undergoes a conformational change; (3) phosphoryl transfer occurs (the chemistry step); (4) a post-chemistry conformational change occurs; (5) pyrophosphate is released; (6) RNA or DNA translocation. …”
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CyTOF as a suitable tool for stratification and monitoring of cancer patients by Barbara Seliger, Chiara Massa

“…Abstract Despite the recent implementation of immunotherapies into clinical practice of various tumor types, the immunobiology of tumors and in particular the role and clinical relevance of the different immune cell populations and their function still remained unclear. Therefore, an in depth analysis of the complex landscape of immune cell populations and their soluble mediators in the peripheral blood and tumor microenvironment of cancer patients is urgently needed. …”
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Path Optimization Strategy for Unmanned Aerial Vehicles Based on Improved Black Winged Kite Optimization Algorithm by Shuxin Wang, Bingruo Xu, Yejun Zheng, Yinggao Yue, Mengji Xiong

“…The Black-winged Kite Optimization Algorithm (BKA) is likely to experience a sluggish convergence rate when confronted with the optimization of complex multimodal functions. The fundamental algorithm has a tendency to get stuck in local optima, thus rendering it arduous to identify the global optimal solution. …”
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Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. by Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays

“…As RPs co-assemble into one multi-subunit complex, mutation of the genes that encode RPs might be expected to give rise to phenocopies, in which the same phenotype is associated with loss-of-function of each individual gene. …”
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Heterogeneidade nos deficits de percepção do movimento em perturbações do desenvolvimento: o caso do Autismo e da Síndrome de Williams by Ana Maria Abreu, Scania de Schonen

“…The data are discussed in terms of the dissociations found in the motion detection deficit patterns, possibly related with complex co-morbid visual-attention disorders.…”
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Novel Approaches to Ileocolic and Perianal Fistulising Crohn’s Disease by Gaetano Luglio, Gianluca Cassese, Alfonso Amendola, Antonio Rispo, Francesco Maione, Giovanni Domenico De Palma

“…Nowadays, the introduction of both laparoscopy and novel surgical techniques, the improvement of recovery pathways, and the opening of new frontiers are allowing healthcare professionals to deal with complex and recurrent scenarios, trying to spare bowel and anal function, thus ensuring a better quality of life for the patient. …”
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Characterization of the mRNA untranslated regions [UTR] of the Trypanosoma cruzi LYT1 isoforms derived by alternative trans-splicing by César Augusto Ramírez, Julián Camilo Casas, María Isabel Ospina, José María Requena, Concepción J. Puerta

“…In trypanosomatids, gene expression is mainly regulated at posttranscriptional level, through mechanisms based on the interaction between RNA Binding Proteins [RBPs] and motifs present in the untranslated regions [UTRs] of them RNAs, which altogether form ribonucleoproteic complexes [RNP] that define the fate of the mRNA. The pre-mRNA derived from the LYT1 gene of Trypanosoma cruzi, is processed by alternative trans-splicing, resulting in different mRNAs which code for the isoforms mLYT1 and kLYT1, proteins having differential expression, cellular location and function. …”
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Vimar Is a Novel Regulator of Mitochondrial Fission through Miro. by Lianggong Ding, Ye Lei, Yanping Han, Yuhong Li, Xunming Ji, Lei Liu

“…Because Vimar could co-immunoprecipitate with Miro in vitro, we speculated that Vimar might be the GEF of Miro. In support of this hypothesis, a loss-of-function (LOF) vimar mutant rescued mitochondrial enlargement induced by a gain-of-function (GOF) Miro transgene; whereas a GOF vimar transgene enhanced Miro function. …”
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Biological pathways leading to septo-optic dysplasia: a review by Ludovica Pasca, Davide Politano, Federica Morelli, Jessica Garau, Sabrina Signorini, Enza Maria Valente, Renato Borgatti, Romina Romaniello

“…Abstract Background The precise etiology of septo-optic dysplasia (SOD) remains elusive, to date a complex interaction between genetic predisposition and prenatal exposure to environmental factors is believed to come into play. …”
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Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism by Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng

“…SEMAs and its receptors formed a complex network, and other members of the SEMA-signaling pathway might also be involved in the pathogenesis of IHH.…”
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Breast cancer in young patients. Peculiarities of prognosis and adjuvant hormone therapy (a literature review) by D. N. Kravchenko, A. A. Parokonnaya, M. I. Nechushkin, E. A. Nikitina, N. D. Hakurinova

“…Despite modern methods of diagnosis and complex treatment used in young patients, survival in this age group are inferior that’s associated with biological and morphological peculiarities of BC in young age. …”
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HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome by Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. …”
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Detection of Toxicity of heavy metal pollution in soils based on their respiratory activity in native soils and simulated substrates (a case-study of the protected area “YAMSKAYA s... by N. O. Bakunovich, O. S. Khokhlova, T. N. Myakshina, A. V. Rusakov, A. S. Shapovalov

“…The area “Yamskaya Steppe” of “Belogorye” preserve is located in Belgorod Oblast near the concentration of mining factories: Lebedinskiy and Stoylenskiy mining and concentration complex (MCC), complexes of “KMA-ore” and Oskol metallurgical, TPP etc. …”
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Identification of subcellular localization of Arabidopsis AGO2 by ZHAO Li, XIA Wenqiang, CAI Xinzhong

“…Some members of AGO family proteins have been found to bind small RNAs, which are generated through the function of DCLs, to form a RNA-induced silencing complex (RISC), leading to RNA silencing at either transcriptional or post-transcriptional level, thus results in alternation in development, abiotic and biotic stress resistance. …”
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Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation by Alvaro Rada‐Iglesias

“…Abstract In embryonic stem cells (ESCs), silent genes with major developmental functions display a unique epigenetic state in which strong and broad binding by Polycomb repressive complexes (PRCs) is accompanied by the presence of poised RNA polymerase II (RNAPII) and activating histone marks (e.g. …”
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Acute Childhood Cardiorenal Syndrome and Impact of Cardiovascular Morbidity on Survival by Wasiu A. Olowu

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Ray Tracing Methods for Correcting Chromatic Aberrations in Imaging Systems by Dmitry Reshidko, Masatsugu Nakanato, José Sasián

“…While the use of aberration formulas might be effective for some simple optical systems, it has limitations for complex and fast systems. …”
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