The Porphinoids - Versatile Biological Catalyst Molecules by Bernhard Kräutler

“… The natural porphinoids, such as the iron complex heme, the magnesium complex chlorophyll a, the nickel complex coenzyme F430, and the (corrinoid) cobalt complex coenzyme B12 play central roles in all spheres of life, e.g. as cofactors for oxygen or electron transport, for collecting light and transforming energy, and as catalysts in biosynthesis. – How the porphinoid structures developed in nature, how their often unique properties arise from special interactions between the bound metal ions and the macrocyclic ligands, and to which particular chemical reactivities and modes of action the porphinoids owe their specific biological functions – these are central questions to this topic. …”
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The Computational Analysis and Phytochemical Screening Targeting Dihydrolipoamide Dehydrogenase (DLD) for Alzheimer's Disease: A Molecular Dynamics Simulation Study by Muhammad Mazhar Fareed

“…Dihydrolipoamide dehydrogenase (dld), and DLD1 are specific chemicals comprised of two enzymes/complexes of protein; pyruvate dehydrogenase and α-ketoglutarate dehydrogenase physiologically related to AD and have a noteworthy function in energy metabolism. …”
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Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase. by Daniel Barajas, Isabel Fernández de Castro Martín, Judit Pogany, Cristina Risco, Peter D Nagy

“…In this paper, we show an unexpected key role for the conserved Vps4p AAA+ ATPase, whose canonical function is to disassemble the ESCRT complexes and recycle them from the membranes back to the cytosol. …”
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Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. by Paolo Guazzi, Luca Goitre, Elisa Ferro, Valentina Cutano, Chiara Martino, Lorenza Trabalzini, Saverio Francesco Retta

“…The KRIT1 protein contains multiple interaction domains and motifs, suggesting that it might act as a scaffold for the assembly of functional protein complexes involved in signaling networks. …”
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Alteration of phycobilisome excitation energy transfer properties in response to attenuations in peripheral electron flow by Zhanjun Guo, Sharon L. Smolinski, Paul W. King, Carolyn E. Lubner

“…PCC 6803 (S. 6803), two types of phycobilisome (PBS) complexes, CpcG-PBS and CpcL-PBS, function to harvest light energy for photosynthetic reaction centers (RCs), photosystem I (PSI) and photosystem II (PSII). …”
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A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. by Houman Ashrafian, Louise Docherty, Vincenzo Leo, Christopher Towlson, Monica Neilan, Violetta Steeples, Craig A Lygate, Tertius Hough, Stuart Townsend, Debbie Williams, Sara Wells, Dominic Norris, Sarah Glyn-Jones, John Land, Ivana Barbaric, Zuzanne Lalanne, Paul Denny, Dorota Szumska, Shoumo Bhattacharya, Julian L Griffin, Iain Hargreaves, Narcis Fernandez-Fuentes, Michael Cheeseman, Hugh Watkins, T Neil Dear

“…Heterozygous Python hearts show reduced levels of mitochondria enzyme complexes and suffer from cardiac ATP depletion. The resulting energy deficiency may contribute to cardiomyopathy. …”
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Genomic insights into the plasmidome of non-tuberculous mycobacteria by Margo Diricks, Florian P. Maurer, Viola Dreyer, Ivan Barilar, Christian Utpatel, Matthias Merker, Nils Wetzstein, Stefan Niemann

“…Furthermore, we analyzed 3755 draft genome assemblies from over 200 NTM species and 5415 short-read sequence datasets from six clinically relevant NTM species or complexes including M. abscessus, M. avium complex, M. ulcerans complex and M. kansasii complex, for the presence of these plasmids. …”
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Developmental Coordination Disorder: Is Clumsy Motor Behavior Caused by a Lesion of the Brain at Early Age? by Mijna Hadders-Algra

“…Perinatal adversities play an evident etiological role in the development of complex MND, suggesting that it might be attributed to a lesion of the brain at early age. …”
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Integrated Information Theory and the Phenomenal Binding Problem: Challenges and Solutions in a Dynamic Framework by Chris Percy, Andrés Gómez-Emilsson

“…The solution—that particular entities aggregable from multiple units (‘complexes’) define existence—might work in a static picture, but introduces issues in a dynamic system. …”
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Inferring the temporal order of cancer gene mutations in individual tumor samples. by Jun Guo, Hanliang Guo, Zhanyi Wang

“…The initial mutations appear to be dedicated to acquiring the function of evading apoptosis, and some order constraints might reflect potential regularities. …”
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Immunoglobulin Free Light Chain Dimers in Human Diseases by Batia Kaplan, Avi Livneh, Ben-Ami Sela

“…The presence of tetra- and trimolecular complexes formed due to dimer-dimer and dimer-monomer interactions was detected in the myeloma serum. …”
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Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay by Shishir Singh, Shishir Singh, Shishir Singh, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Mateo Murillo-León, Aura María Bastidas Quintero, Aura María Bastidas Quintero, Florence Melbert, Florence Melbert, Klaus Pfeffer, Daniel Degrandi, Tobias Steinfeldt, Tobias Steinfeldt

“…Toxoplasma gondii (T. gondii) virulence in mice depends on different multiprotein complexes that assemble at the parasitophorous vacuole membrane (PVM) of the parasite. …”
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A cohesin-independent role for NIPBL at promoters provides insights in CdLS. by Jessica Zuin, Vedran Franke, Wilfred F J van Ijcken, Antoine van der Sloot, Ian D Krantz, Michael I J A van der Reijden, Ryuichiro Nakato, Boris Lenhard, Kerstin S Wendt

“…Heterozygous mutations of NIPBL were found in 50% of the cases of Cornelia de Lange Syndrome (CdLS), a human developmental syndrome with a complex phenotype. However, no defects in the mitotic function of cohesin have been observed so far and the links between NIPBL mutations and the observed developmental defects are unclear. …”
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THE INFLUENCE OF CORONARY BYPASS ON ENDOTHELIAL AND ERECTILE DYSFUNCTION IN ISCHEMIC HEART DISEASE by S. A. Pomeshkina, E. V. Pomeshkin, T. Yu. Sergeeva, I. N. Sizova, O. L. Barbarash

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Characterisation and validation of insertions and deletions in 173 patient exomes. by Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka

“…Recent advances in genomics technologies have spurred unprecedented efforts in genome and exome re-sequencing aiming to unravel the genetic component of rare and complex disorders. While in rare disorders this allowed the identification of novel causal genes, the missing heritability paradox in complex diseases remains so far elusive. …”
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ASSOCIATION OF DEPRESSION AND ERECTILE DYSFUNCTION IN CARDIAC PATIENTS by S. A. Pomeshkina

“…The manifestations of the cause-effect relationship between ED and depression could vary: ED might be a symptom of depression, while depression could also be caused by ED, and the improvement in erectile function can reduce the severity of depressive symptoms. …”
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The Role of miRNA in Plant Adaptation to Abiotic Stress by Mohammad Hadi Taleb, Ahmad Arzani

“…The siRNAs then guide a protein complex called RISC (RNA-induced silencing complex) to complementary mRNA sequences. …”
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Analyse des représentations de professionnels impliqués dans deux parcours de sujets dits « incasables » by Gillonne Desquesnes, Nadine Proia-Lelouey, Didier Drieu

“…We elaborate the idea that the educational institution might care efficiently for them, if the containing function of health professionals, who would maintain supervision systems in order to protect the team of the attacks of the youngsters, was provided.…”
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Introduction: Melting Point by Sérgio Henrique Faria

“… We might think that high mountain regions, being remote and frozen, would be naturally isolated and protected from human action – the last untouched corners of the planet. …”
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The length and strength of compartmental interactions are modulated by condensin II activity. by Randi Isenhart, Son C Nguyen, Leah Rosin, Weihuan Cao, Patrick Walsh, Haris Muzaffar, Christopher E Ellison, Eric F Joyce

“…The spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained more enigmatic. …”
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