Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine by Yilin Meng, Lu Sui, Ligeer Che, Zihang Jin, Yutong Ma, Li Sun

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Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation by Lulu Meng, Meng Meng, Ruonan Zhang, Ayinisa Wubulikasimu, Hao Peng, Lu Zhang, Xinwen Chang, Guihai Ai, Gang Zou, Qizhi He, Kai Wang, Ming Liu, Tao Duan

“…ABSTRACT Although preterm birth (PTB) is one of the major causes of perinatal mortality and neonatal morbidity, little is known about its complex etiology. An abnormal cervicovaginal microbiome during pregnancy is associated with an increased risk of PTB. …”
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Functional geometry of the left ventricle in dilated cardiomyopathy before and after resynchronization therapy by T. V. Chumarnaya, O. E. Solovyova, Yu. S. Alueva, S. P. Mikhailov, O. V. Ostern, V. V. Kochmasheva, O. V. Sopov, A. Sh. Revishvili, V. S. Markhasin

“…Changes of sphericity index betweenend diastole and end systole <3,5% selects patients with the highestprognostic significance comparing with other parameters.Conclusion. Disorders of functional geometry of the LV, particularly anincrease of non-homogeneity and asynchronicity parameters of theregional motion of the wall, decrease of dynamical changes of LVsphericity indexes, might influence contractility and pumping function ofthe heart, and have diagnostic significance in selection of patientsresponding to CRT.…”
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TMT-Opsins differentially modulate medaka brain function in a context-dependent manner. by Bruno M Fontinha, Theresa Zekoll, Mariam Al-Rawi, Miguel Gallach, Florian Reithofer, Alison J Barker, Maximilian Hofbauer, Ruth M Fischer, Arndt von Haeseler, Herwig Baier, Kristin Tessmar-Raible

“…Many of these opsins have been shown to function as light receptors. This raises the question of whether this large number might mainly reflect functional redundancy or rather maximally enables teleosts to optimally use the complex light information present under water. …”
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Functional thalamocortical innervation of VIP- and SST-expressing GABAergic interneurons in mouse barrel cortex by Michael Feyerabend, Mirko Witte, Martin Möck, Jochen F. Staiger

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Exploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors by Jifang Liu, Jifang Liu, Zhang Ye, Zhang Ye, Yi Zhang, Yi Zhang, Wan Su, Wan Su, Jie Liu, Jie Liu, Tianqi Chen, Yanan Shi, Lulu Liu, Jiao Lu, Zian Cai, Qing Zhong, Pei Wang, Jun Pu, Jun Pu, Jinghua Liu, Jinghua Liu, Yuchen Wei, Yuchen Wei, Hui Pan, Hui Pan, Huijuan Zhu, Huijuan Zhu, Kan Deng, Kan Deng, Renzhi Wang, Renzhi Wang, Lin Lu, Lin Lu, Xiaomin Hu, Yong Yao, Yong Yao

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Cognitive neuroscience approach to explore the impact of wind turbine noise on various mental functions by Agnieszka Rosciszewska, Maciej Buszkiewicz, Gabriela Dobrzynska-Kobylec, Anna Klichowska, Tomasz Przybyla, Blanka B. Nagy, Andrzej Wicher, Michal Klichowski

“…Here, a cognitive neuroscience approach is proposed to experimentally and multifactorial explore wind turbine noise’s impact on various mental functions. We used recordings from an actual wind turbine to investigate its effects on the dynamics of brain waves crucial for complex cognitive tasks, as well as on sustained attention and inductive reasoning in healthy adult volunteers. …”
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Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate. by Jes-Rite Michaels, Paul P R Iyyanar, Ammar Husami, Andrew M Vontell, Samantha A Brugmann, Rolf W Stottmann

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Gastric juice MicroRNAs as biomarkers for functional dyspepsia: an observational case-control study by Radu A. Farcas, Teodora Surdea-Blaga, Ştefan Popa, Flaviu Rusu, Alexandra Chira, Cristina Sabo, Vlad-Ionuţ Nechita, Liviuţa Budişan, Oana Zanoaga, Ioana Berindan-Neagoe, Ioana Berindan-Neagoe, Ioana Berindan-Neagoe, Ştefan Strilciuc, Dan L. Dumitrascu

“…Background and aimsMicroRNAs (miRNAs, miRs) are stable RNA molecules that regulate gene expression and hold promise as biomarkers. Functional dyspepsia (FD), a complex gastrointestinal disorder, is characterized by motility dysfunction, visceral hypersensitivity, and gut microbiome alterations. …”
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Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer by Marcin Duleba, Eliza Zimoląg, Joanna Szuszkiewicz, Marcin Serocki, Joanna Szklarczyk, Olga Dracz, Alexander Kurzejamski, Izabella Więckowska, Marcelina Chmiel, Barbara Lipert, Katarzyna Sarad, Joanna Krawczyk, Oleksii Bryzghalov, Agata Stachowicz-Wałaszek, Karolina Pyziak, Joanna Drozdowska, Krzysztof Baczyński, Konrad Wojtowicz, Maurycy Chronowski, Krzysztof Rataj, Magdalena Otrocka, Michał Mikula, Paula Feliksiak, Rafał Dziadziuszko, Tomasz Rzymski, Andrew Thomason, Krzysztof Brzózka, Andrzej Mazan

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Effect of lipid peroxidation on the allergenicity and functional properties of soybean β-conglycinin (7S) and glycinin (11S) by Liying Ye, Liangtao Lü, Xiao Lin, Kan He, Xiaoquan Yang, Zhili Wan, Lizhong Liu, Haiqian Wu, Shaojun Xing, Xuli Wu

“…A mouse model showed that oxidation reduced the IgE, IgG, and IgG1 levels, as well as reduced histamine and mMCP-1 release in serum, which might suppress the allergic reaction. In conclusion, the lipid peroxidation treatment likely causes changes to the functional properties of soybean, decreasing the potential allergenicity of 7S and 11S.…”
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Run-off impacts on Arctic kelp holobionts have strong implications on ecosystem functioning and bioeconomy by Sarina Niedzwiedz, Claudia Schmidt, Yunlan Yang, Bertille Burgunter-Delamare, Sebastian Andersen, Lars Hildebrandt, Daniel Pröfrock, Helmuth Thomas, Rui Zhang, Børge Damsgård, Kai Bischof

“…Abstract Kelps (Laminariales, Phaeophyceae) are foundation species along Arctic rocky shores, providing the basis for complex ecosystems and supporting a high secondary production. …”
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The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms by Tong Sun, Xiao Han

“…Since mammalian PIWI subfamily proteins are mainly germline specific, it was once thought that piRNAs might only function in the gonadal cells. However, evidence from the later research suggest that piRNAs are broadly expressed in many kinds of somatic cells and are involved in numerous pathological condition far beyond those have been reported in the germline. …”
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Immune cells and the trajectories of depression, anxiety, and cognitive function among people with amyotrophic lateral sclerosis by Yihan Hu, Elie Deeba, Ulf Kläppe, Linn Öijerstedt, John Andersson, Nicolas Ruffin, Fredrik Piehl, Caroline Ingre, Fang Fang, Christina Seitz

“…Background: Amyotrophic lateral sclerosis (ALS) represents a complex syndrome characterized by motor, psychiatric, and cognitive symptoms, where associations between cellular immune features and non-motor manifestations remain unknown. …”
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Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma by Elisabeth Jehli, Fabienne Burri, Niklaus Denier, Franz Moggi, Andrea Federspiel, Roland Wiest, Maria Stein, Tobias Bracht, Matthias Grieder, Leila M. Soravia

“…Here, we additionally aimed to investigate fronto-limbic functional connectivity (FC) in patients with AUD with (AUD-CT) and without (AUD-noCT) CT. …”
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Diaphragm Fatigue Does Not Impact Breathing Mechanics or Function in People with Chronic Low Back Pain by Mitchell UH, Robinson LT, Brinkman J, Bruening DA, Bowden AE, Allen SP

“…Chronic low back pain (CLBP) is a complex musculoskeletal condition and has been associated with respiratory problems and altered breathing mechanics. …”
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The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin

“…However, the functional consequences of this interaction on 5-HT7R-mediated signaling remained enigmatic. …”
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Hidden Scars: The impact of torture, traumatic brain injury, and PTSD on executive functions - a narrative review by Miguel Diaz, Inger Wallin Lundell

“…Introduction: Victims of torture are often subjected to physical violence, which can result in traumatic brain injury (TBI) and PTSD. Executive functions encompass a complex set of higher cognitive abilities that include memory, inhibitory control, cognitive flexibility, planning, reasoning, and problem solving. …”
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Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation by Juliane Lokau, Maria Agthe, Christoph Garbers

“…IL-6 is a rare example, where its soluble receptor (sIL-6R) has agonistic properties, so that the IL-6/sIL-6R complex is able to activate cells that are usually not responsive to IL-6 alone (trans-signaling). …”
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Parasite community of the pelagic thresher Alopias pelagicus (Lamniformes) as additional indicator of trophic network status and functioning by Mario Santoro, Flavia Occhibove, Luigi Maria Cusano, Marialetizia Palomba, Bernald Pacheco-Chaves, José Miguel Carvajal-Rodríguez, Monica Monge-Amador, Alicia Rojas, Alberto Solano-Barquero

“…Parasite communities of sharks, which have high structural importance within trophic webs, might well be included among bioindicators of trophic network functioning. …”
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