miR-210 loss leads to widespread phenotypic and gene expression changes in human 293T cells by Xiaoxiao Zhang, Zhen Meng, Chengyong Yang, Chenghao Wang, Kexin Zhang, Anxin Shi, Jingjing Guo, Yong Feng, Yan Zeng

“…Surprisingly, the mRNA levels of most previously reported miR-210 target genes were not induced upon miR-210 KO, suggesting a need to reexamining and studying human miR-210 functions directly and comprehensively. Thus, our work established a human cellular system and opportunity to unravel the complexity of the regulatory networks by miR-210.…”
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Application of a Hybrid Model Based on CEEMDAN and IMSA in Water Quality Prediction by GUO Li-jin, WU Hao-tian

“…Next, Fuzzy Dispersion Entropy (FuzzDE) categorized the components into high-, medium-, and low-complexity subsequences. Then, an Improved Mantis Search Algorithm (IMSA) optimized three distinct models: Bidirectional Long Short-Term Memory (BiLSTM) for high-complexity components, Least Squares Support Vector Regression (LSSVR) for medium-complexity components, and Extreme Learning Machine (ELM) for low-complexity components. …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…Conclusions This study constructed a comprehensive rumen DNA virome profile for Holstein dairy cows, elucidating the structural and functional complexity of rumen viruses, the roles of AMGs, and vOTU-hMAG linkages. …”
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Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling by Joann Phan, Suneer Jain, Jurgen F. Nijkamp, Rajkumar Sasidharan, Ashish Agarwal, Julia K. Bird, Anneleen Spooren, Jonas Wittwer Schegg, Emiel Ver Loren van Themaat, Tim N. Mak

“…ABSTRACT Despite the complexity of the gut microbiome, several scores that use taxonomic characteristics exist that attempt to identify a healthy gut or gastrointestinal disease. …”
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Abstract 157: Evaluating the Impact of Pre‐Procedural CTA on Fluoroscopy Time and Conversion Rates by Zachary Lodato, Ivo Bach, Humza Haque, Elan Meltzer, Priyank Khandelwal

“…Introduction Cerebral angiography, essential in managing cerebrovascular disorders, exposes patients to ionizing radiation, with dose dependence on procedure complexity, patient's body habitus, and equipment used, raising safety concerns (1,2). …”
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The Effects of Pregnancy and Childbirth on Women's Health-Related Quality of Life: A Scoping Review by Asmaa Othman

“…Collectively, these findings underscore the complexity of the maternal experience, calling for a holistic approach to healthcare that addresses the diverse challenges women face during this pivotal life stage. …”
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Decoration of Mg/Fe layered double hydroxides on coffee waste biochars for enhanced adsorption and selectivity of phosphate ions: Mechanistic studies by Jaegwan Shin, Hojung Rho, Yeonjung Cho, Jinwoo Kwak, Changgil Son, Sangwon Kim, Seohyun Ki, Yong-Gu Lee, Hee-Joong Kim, Sang-Ho Lee, Yongeun Park, Kangmin Chon

“…The variations in the main adsorptive removal mechanisms of PO43- ions by CB from the ligand exchange with alcohol functional groups to the anion exchange with Cl and electrostatic surface complexation with metal contents via the Mg/Fe LDH decoration could significantly improve the selectivity of PO43- ions (decreasing rate of Qe under the co-existing anions: CB = 26.7–98.7 % and MF-L@CB = 1.9–44.2 %). …”
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Assessment of The Potential Interference and Conflict of Artificial Intelligence With Human Rights and Citizenship: Challenges and Solutions by Hossein Khazaei, Mojtaba Hemmati

“…Determining legal responsibilities for the actions and functions of AI systems is complex. Traditional legal systems assign responsibility based on intention and action. …”
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Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs by Zhen Wang, MD, Mingxiao Li, MD, Peng Xia, BS, Chao Jiang, MD, Ting Shen, MD, Jiaming Ma, MD, Yu Bai, MD, Suhui Zhang, MD, Yiwei Lai, MD, Sitong Li, MS, Hui Xu, MD, Yang Xu, MD, Tong Ma, MS, Lie Ju, PhD, Liu He, PhD, Li Dong, MD, Caihua Sang, MD, Deyong Long, MD, Yuzhong Chen, PhD, Xin Du, MD, Zongyuan Ge, PhD, Jianzeng Dong, MD, Wen-Bin Wei, MD, Changsheng Ma, MD

“…Background: Patients with atrial fibrillation (AF) have a higher risk of cognitive impairment (CI). However, complexity of CI diagnosis and lack of simple screening approaches limited early screening and intervention of CI in AF patients. …”
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Wetland restoration suppresses microbial carbon metabolism by altering keystone species interactions by Huijie Zheng, Huijie Zheng, Deyan Liu, Ye Li, Zengming Chen, Junjie Li, Junjie Li, Yanhong Dong, Yanhong Dong, Cong Yang, Cong Yang, Yuncai Miao, Junji Yuan, Weixin Ding, Weixin Ding

“…Soil bacteria play a pivotal role in regulating multifaceted functions of terrestrial ecosystems. Unraveling the succession of bacterial communities and the feedback mechanism on soil organic carbon (SOC) dynamics help embed the ecology of microbiome into C cycling model. …”
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Language and ethnicity in Central and Eastern Europe: Some theoretical aspects by George Schopflin

“…We are not presented with a narrow and simplistic narration but are rather compelled to thoroughly perceive the multilateral complexity of this problem. Hence the author tries to trace the solutions that entail inter-ethnic tensions, although he primarily identifies the 'true' causes for such tensions. …”
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The NASA Exoplanet Archive and Exoplanet Follow-up Observing Program: Data, Tools, and Usage by Jessie L. Christiansen, Douglas L. McElroy, Marcy Harbut, David R. Ciardi, Megan Crane, John Good, Kevin K. Hardegree-Ullman, Aurora Y. Kesseli, Michael B. Lund, Meca Lynn, Ananda Muthiar, Ricky Nilsson, Toba Oluyide, Michael Papin, Amalia Rivera, Melanie Swain, Nicholas D. Susemiehl, Raymond Tam, Julian van Eyken, Charles Beichman

“…In anticipation of continued exponential growth in the number of exoplanetary systems and the increasing complexity in our characterization of these systems, the NEA has restructured its primary tables and interfaces, as well as extending and standardizing their modes of access. …”
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Complete sequencing of the mitochondrial genome of tea plant Camellia sinensis cv. ‘Baihaozao’: multichromosomal structure, phylogenetic relationships, and adaptive evolutionary an... by Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zixu Wang, Zixu Wang, Zixu Wang, Zixu Wang, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Sijie Liu, Sijie Liu, Sijie Liu, Sijie Liu, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yihui Gong, Yihui Gong, Yihui Gong, Yihui Gong

“…It systematically unveils its multi-chromosomal structure, RNA editing patterns, and adaptive evolutionary mechanisms, providing critical theoretical insights into the structural complexity and evolutionary mechanisms of the tea plant mitochondrial genome.MethodsThe mitochondrial genome was fully analyzed using genome sequencing and annotation techniques. …”
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Architecture and the Time of Space by Deborah Hauptman

“…Reflecting on this history, that post-war moment of theory, one cannot help but be struck by the complexity and the ambiguity of the adventure; qualities most evident in the fact that new spaces and new means of writing and drawing, of thinking and making emerged. …”
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The Circular Kitchen by Bas Jansen

“…However, existing methods do not fully incorporate the complex, multiple use cycles inherent in circular products and components. …”
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The European Synarchy: New Discourses on Sovereignty by Dimitris N. Chryssochoou

“…It is thus possible to capture the endemic systemic complexity of the regional process through the lens of new theoretical perspectives with a view to developing a series of novel understandings of EU governance in the early twenty-first century. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Much of the logistical burden falls on those living with SMI to educate themselves and initiate the completion of a PAD.[11] However, many of those living with SMI already face additional burdens that prevent their successful navigation of a complex healthcare system, including poverty, marginal housing, and food insecurity.[12] In addition, individuals with SMI tend to be more socially isolated, with few others to trust besides their providers.[13] Efforts to promote the uptake of PADs by those living with SMI that neglect these additional burdens risk exacerbating health inequities faced by those with SMI. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Background High-risk patients with complex anorexia nervosa are managed in inpatient/day patient care, but re-admission rates are high, and new treatments are needed. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…On detailed assessment of feasibility, we concluded that identifying index cases (men presenting with LUTS) may be susceptible to poor coding of presentations in primary care (e.g. when presenting with sometimes vague symptoms). Complex resource intensive work would be required to ascertain cases and outcomes, and the other study pressures (delayed study recruitment and data collection during the pandemic years) meant that this was not feasible. …”
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