Agreement of glomerular filtration rate estimation equations for chemotherapy dosing in cancer patients at a tertiary referral hospital in Sub-Saharan Africa. by Wubshet Jote Tolossa, Tigist Workneh Leulseged, Abdu Adem, Feyissa Challa, Tirumebet Mezgebu, Ruth S Aytehgeza, Nebiat Adane Mera, Kalsidagn Girma Asfaw, Momina M Ahmed, Kebede H Begna

“…<h4>Introduction</h4>Narrow therapeutic indices of chemotherapeutic agents necessitate precise dosing to ensure efficacy and minimize nephrotoxicity. Due to the complexity of directly measuring Glomerular filtration rate (GFR), renal dosing is usually based on GFR estimation equations. …”
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Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery by Floriana Ferro, Caterina Gaspari, Giulia Manfrè, Federica Cernigliaro, Daniela D’Agnano, Ruben Panzica, Edvige Correnti, Maria Rosita Ruta, Francesca Marchese, Renata Pitino, Mariarita Capizzi, Giuseppe Santangelo, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli

“…Headache represents one of the most prevalent and disabling conditions in the pediatric population, with significant repercussions on mental and psychological well-being, as well as on academic achievement and social functioning, ultimately leading to a marked reduction in quality of life. …”
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Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration by Xiaoyu Zhang, Qianping Guo, Jiawei Fang, Qi Cheng, Zhuang Zhu, Qifan Yu, Huan Wang, Youzhi Hong, Chengyuan Liu, Huilin Yang, Caihong Zhu, Bin Li, Li Ni

“…Abstract Nucleus pulposus cells (NPCs) undergo metabolic disorders and matrix pathological remodeling under the influence of various adverse factors during intervertebral disc degeneration (IVDD), whereas post-translational modifications (PTMs) can confer cells with the capacity to respond quickly and adapt to complex environmental changes. Here, SIRT1 protein, a key regulator within PTMs framework, was applied against the hostile degenerative microenvironment. …”
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Solid State Transformers: A Review—Part I: Stages of Conversion and Topologies by Dragoș-Mihail Predescu, Ștefan-George Roșu

“…Converter functionalities are derived based on the number of stages. …”
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Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets by Nira Hernández-Martín, Ignacio Pozo-Cabanell, Rubén Fernández de la Rosa, Luis García-García, Francisca Gómez-Oliver, Miguel Ángel Pozo, Mirjam Brackhan, Pablo Bascuñana

“…Abstract Background Epilepsy is a neurological disorder that affects a significant portion of the global population. However, its complexity and the lack of biomarkers hinder the study of its etiology, resulting in a lack of effective treatments to slow down or halt disease development, also called epileptogenesis. …”
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Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway by Jiale Cai, Xinya Zheng, Xiongbo Luo, Wenli Cui, Xinrui Ma, Shuyi Xu, Lanya Fu, Jiaqi Zhang, Yizhou Xu, Yunlun Li, Ye He, Xianghai Wang, Jiasong Guo

“…Overall, this is the first study to demonstrate that microglial RhoA is essential for SCI repair, the Arhgap25/HIF-1α pathway mediated glucose metabolism might enlighten a novel insight to enrich the understanding on the complex roles of RhoA and microglia in SCI repair. …”
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Transcriptome-derived networks reconstruct distinct immune strategies to counteract fungal infection under different iron availability between Arabidopsis and rice by Antoni Garcia-Molina, Héctor Martín-Cardoso, María Ribaya, Blanca San Segundo, Sílvia Busoms

“…Here, we report antagonistic immune phenotypes in Arabidopsis thaliana and Oryza sativa infected by Colletotrichum higginsianum and Magnaporthe oryzae under different Fe nutritional status. Functional and topological analysis of transcriptional networks unveiled differences in complexity and hierarchy for similar biological functions, as well as in Fe usage and distribution, between the two pathosystems, with a focus on the plant side. …”
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Unravelling the Enigma of Highly Superior Autobiographical Memory: Signs, Symptoms and Treatment Perspectives: A Narrative Review by Rohit Wani, Bhagyesh Sapkale, Supriya Meshram, Sachin R Gedam

“…Currently listed on the global diagnosis list up to 2024, with only 62 documented cases, HSAM presents a fascinating cognitive and neurological complexity, including increased functional connectivity within some brain regions, particularly the left temporoparietal junction. …”
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Improved Binary Grey Wolf Optimization Approaches for Feature Selection Optimization by Jomana Yousef Khaseeb, Arabi Keshk, Anas Youssef

“…Finally, the results revealed that the best approach in terms of classification accuracy, fitness value, and number of selected features had the highest computational complexity.…”
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Phase-lags in large scale brain synchronization: Methodological considerations and in-silico analysis. by Spase Petkoski, J Matias Palva, Viktor K Jirsa

“…Architecture of phase relationships among neural oscillations is central for their functional significance but has remained theoretically poorly understood. …”
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Sustainability Through Directed Change in the Visionary University: From Predicting to Producing the Future by Adrian Curaj, Mihai Păunică, Andreea Popa, Cosmin Holeab, Octavian-Dragomir Jora

“…The sustainability of a university can be questioned from the perspective of three functional goals, henceforth setting the analytical framework: (i) the development of suited knowledge (dynamic and evolving, mirroring the complexity of the socioeconomic environment, definitely internationalised and future-oriented), (ii) the development of students’ skills, as future workforce (valuing the knowledge) and (iii) the development of institutional capacities, in agile constructions (adequate to face the first two challenges). …”
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Divergent impact of long-term anthropogenic nitrogen inputs on global particulate and mineral-associated organic carbon by Xinhao Peng, Wei Wei, Shuli Niu, Yuanyuan Huang, Liding Chen

“…Anthropogenic nitrogen inputs increase the levels of reactive nitrogen, significantly influencing SOC dynamics. Given the complexity of SOC, it remains unclear how its key components—particulate organic carbon (POC) and mineral-associated organic carbon (MAOC)—respond to nitrogen addition over time, due to their fundamental differences in formation, persistence, and functions. …”
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Adsorption Properties of Fishbone and Fishbone-Derived Biochar for Cadmium in Aqueous Solution by Nan Pei, Wenwen Luo, Qingqing Huang, Yuebing Sun

“…Moreover, the potential adsorption mechanisms of Cd²⁺ on FBM and fishbone-derived biochar might be related to pore filling, ion exchange, complexation with oxygen functional groups, and precipitation with the minerals on the biochar surface. …”
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LGBT Actors, Ritual and Martial Arts Groups, and State-Building in Post-Conflict Timor-Leste by Lili Chen, Laura Sjoberg

“…Taking these common assumptions for granted, one would seriously underestimate the complexity of ritual/martial arts groups (RAGs and MAGs) in Timor-Leste. …”
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Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile by Claudia Carrera-Bravo, Claudia Carrera-Bravo, Tianchi Zhou, Tianchi Zhou, Trang Chu, Jing Wen Hang, Harshvardhan Modh, Chenyuan Huang, Chenyuan Huang, Sitong Zhang, Sitong Zhang, Haining Hao, Haining Hao, Haining Hao, María José Cabada-García, Benoit Malleret, Benoit Malleret, Matthias G. Wacker, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Jiong-Wei Wang, Laurent Rénia, Kevin S. W. Tan

“…Notably, the outward budding and blebbing of the iRBC plasma membrane led to the formation of EVs, which are complex structures with unique functional properties. …”
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PO48 | Thrombotic risk evaluation and thrombophilia testing in beta-thalassemia patients: a retrospective cohort analysis from a reference regional center

“…Nineteen had complete screening (including both functional and genetic testing), while 18/65 and 28/65 patients had partial genetic and functional screening, respectively (Table 1). …”
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DATA MINING IN RELATIONAL SYSTEMS by Valentin Filatov, Valerii Semenets, Oleg Zolotukhin

“…The search for association rules is far from a trivial task, as it might seem at first glance. One of the problems is the algorithmic complexity of finding frequently occurring itemsets, since as the number of items grows, the number of potential itemsets grows exponentially.…”
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Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis by Barbara Vergani, Massimo Milione, Marco Vitellaro, Giulio Ferrero, Veronica Huber, Luca Lalli, Agata Cova, Paola Frati, Flavio Arienti, Licia Rivoltini, Simonetta Guarrera, Laura Cattaneo, Luca Sorrentino, Elena Daveri, Elena Casiraghi, Marta Zorza, Manuela Gariboldi, Patrizia Pasanisi, Daniele Morelli, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Vincenzo Lagano, Giovanna Sabella, Biagio E Leone

“…Background Colorectal cancer (CRC) remains a significant healthcare burden worldwide, characterized by a complex interplay between obesity and chronic inflammation. …”
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Streamlining cVEP Paradigms: Effects of a Minimized Electrode Montage on Brain–Computer Interface Performance by Milán András Fodor, Atilla Cantürk, Gernot Heisenberg, Ivan Volosyak

“…Three experimental conditions were tested: a baseline 16-electrode configuration, a reduced 6-electrode setup without retraining, and a reduced 6-electrode setup with retraining. (3) Results: Our results indicate that, on average, performance declines with fewer electrodes; nonetheless, retraining restored near-baseline mean Information Transfer Rate (ITR) and accuracy for those participants for whom the system remained functional. The results reveal that for a substantial number of participants, the classification pipeline fails after electrode removal, highlighting individual differences in the cVEP response characteristics or inherent limitations of the classification approach. (4) Conclusions: Ultimately, this suggests that minimal cVEP-BCI electrode setups capable of reliably functioning across all users might only be feasible through other, more flexible classification methods that can account for individual differences. …”
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The meaning of “total pain” in the context of living and dying with dementia by Sarah Elizabeth Field-Richards, Louise Bramley, Jemima Collins, Alison Cowley, Rowan Harwood

“…Using a palliative care framework and existing literature, we critically consider the bio-psycho-socio-spiritual impact of dementia, to explore how total pain might manifest and be experienced in this context.Findings and interpretationWe highlight the complexity, nuance and socially contingent nature of the impact of living and dying with dementia. …”
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