Incremental data integration for tracking genotype-disease associations. by Tomasz Konopka, Damian Smedley

“…Incremental integration is thus a suitable framework for tracking functional annotations and linking to complex human pathology.…”
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Wisdom of the Established Pattern by Joel Janhonen

“…Attaining an exhaustive comprehension of the complex interactions of natural and social worlds is impossible, so we have evolved to operate by relying on a built-in navigation system. …”
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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…These findings demonstrate that peroxisomal impairments in microglia exacerbate inflammatory response and ROS/NO production, affecting the survival of neurons and oligodendrocytes, as well as neuronal morphology and function. This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. …”
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SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice by Ziying Jiang, Bin Liu, Tangsheng Lu, Xiaoxing Liu, Renjun Lv, Kai Yuan, Mengna Zhu, Xinning Wang, Shangbin Li, Song Xu, Xinyu Wang, Yifei Wang, Zhenfang Gao, Peiqing Zhao, Zongyong Zhang, Junwei Hao, Lin Lu, Qingqing Yin

“…Abstract Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. The complex pathology of DACD remains unknown. Here, we performed single-nucleus RNA sequencing (snRNA-seq) to demonstrate unique cellular and molecular patterns of the hippocampus from a mouse model of diabetes. …”
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Synergetic Urban Landscape Planning in Rotterdam by Nico Tillie

“…This renders the assignment more complex but certainly no less landscape architectonic. …”
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Phylogenomic Signatures of a Lineage of Vesicular Stomatitis Indiana Virus Circulating During the 2019–2020 Epidemic in the United States by Selene Zarate, Miranda Bertram, Case Rodgers, Kirsten Reed, Angela Pelzel-McCluskey, Ninnet Gomez-Romero, Luis L. Rodriguez, Christie Mayo, Chad Mire, Sergei L. Kosakovsky Pond, Lauro Velazquez-Salinas

“…Collectively, our study reveals the complex dynamics that accompany the evolution of an epidemic lineage of VSIV in nature. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine by Coskun S, Varol S, Ozdemir HH, Agacayak E, Aydın B, Kapan O, camkurt MA, Tunc S, Cevik MU

“…Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. …”
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Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications by Can Qi, Can Qi, Ziwei Zhao, Lin Chen, Le Wang, Yun Zhou, Guochen Duan, Guochen Duan

“…However, we also noted that the formation of NETs is a complex biological process involving the regulation of multiple cytokines and cellular interactions. …”
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An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer by Yun Hu, Lanqiao Sun, Jinhua Wang, Yuan Ji, Lili Feng

“…In addition, we applied qRT-PCR to investigate signature gene expressions between normal breast epithelium cells and breast cancer cells.ResultsWe identified 336 immune-related lymph node-associated DEGs, which were enriched in leukocyte migration, immunoglobulin complex and receptor ligand activity among GO analysis and cytokine-cytokine receptor interaction among KEGG analysis. …”
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Altered fecal microbial and metabolic profiles reveal potential mechanisms underlying anemia in patients with chronic renal failure by Haichao Wang, Wen Xue, Jiafen Cheng, Yipei He, Yaxiang Song, Dayong Hu, Ai Peng, Changbin Li, Hui Bao

“…Furthermore, we observed a complex co-occurrence between anemia of CRF-related gut microbiota species and the characterized metabolites. …”
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Decoupling working memory impairment from grey matter volume changes in female patients with fibromyalgia: Moderating effect of depression by Ana Belén del Pino, Irene Peláez, Alejandro García-Romero, Maria Luisa Fernández-Sánchez, Paloma Barjola, Vanesa Soto-León, Antonio Oliviero, Francisco Mercado

“…Moderation analyses highlighted the importance of considering affective symptoms of fibromyalgia, such as depression, to characterize associations between local grey matter volumes in the insula and prefrontal cortices (orbitofrontal and ventrolateral prefrontal cortex) with working memory functioning. These results suggest that moderate to severe symptoms of depression appear to be critical for understanding the emergence of associations between grey matter volume and working memory, offering valuable new insights into this complex relationship. …”
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Presidential elections of 1997: a comparative analysis of electoral provisions and stereotypes by Lauras Bielinis

“…In the career activity of a politician, an aptitude to manipulate with the complexes of democratic values becomes a compulsory "collection of a gentleman." …”
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Neural Network Dynamics without Minimizing Energy by Mau-Hsiang Shih, Feng-Sheng Tsai

“…Studies of such neural network systems are typically based on the aspect of energy minimization. However, when the complexity and the dimension of neural network systems go up, the use of energy functions might have its own limitations to study CAM. …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…However, it is unclear whether and to which extent these events might affect frailty, fastening its development or hampering its reversion. …”
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Improved corrosion inhibition effect of a green three-component compound to Q235 steel in acidic solution by Chengjia Bao, Weijian Qi, Zhuanjun Zhu, Ting Xu, Long Zhao, Yanhong Ma, Yang Liu, Bowen Yang, Xueru Luo, Hui Yun, Xiaojuan Li

“…The synergistic anticorrosion layer not only prevented steel surface from corrosive solution attack, but also increased the resistance to retard the charge transfer in the solution. The results might shed new insight in the application of green complex for steel corrosion inhibition.…”
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Edgetic perturbation models of human inherited disorders by Quan Zhong, Nicolas Simonis, Qian‐Ru Li, Benoit Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, Kavitha Venkatesan, Danny Mou, Venus Swearingen, Muhammed A Yildirim, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E Hill, Michael E Cusick, Marc Vidal

“…Abstract Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as ‘nodes’ and ‘edges’, respectively. …”
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PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy by Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera

“…It is an insidious multifactorial disease caused by complex and partially unknown mechanisms that include metabolic dysregulation, local inflammation, fibrosis, and cardiomyocyte apoptosis. …”
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Neural signatures underlying the effect of social structure on empathy and altruistic behaviors by Xia Tian, Zixin Zheng, Renhui Li, Yue-Jia Luo, Chunliang Feng

“…Furthermore, whole-brain and local neural patterns in the anterior insula and premotor cortex robustly discriminated painful (but not non-painful) stimulation of different innocents, suggesting that social structure altered emotional and sensorimotor aspects of empathy. These alterations might be driven by top-down regulation, as indicated by heightened functional connectivity between the lateral prefrontal cortex and sensorimotor areas, as well as between the anterior insula and subgenual anterior cingulate cortex when witnessing the pain of innocents resembling fair (vs. unfair) targets. …”
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Single-Nucleus RNA Sequencing Reveals the Transcriptome Profiling of Ovarian Cells in Adolescent <i>Cyprinus carpio</i> by Mingxi Hou, Jin Zhang, Qi Wang, Ran Zhao, Yiming Cao, Yingjie Chen, Kaikuo Wang, Ning Ding, Yingjie Qi, Xiaoqing Sun, Yan Zhang, Jiongtang Li

“…In addition, the dynamic genes expressed in granulosa cells might relate to the complex communication between different cell types. …”
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