mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity by Michal Fila, Laura Diaz, Joanna Szczepanska, Elzbieta Pawlowska, Janusz Blasiak

“…Arc can form a capsid-like structure that encapsulates a retrovirus-like sentence in the 3′-UTR (untranslated region) of Arc mRNA. Such complex can be loaded into extracellular vesicles and transported to other neurons or muscle cells carrying not only genetic information but also regulatory signals within neuronal networks. …”
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De novo characterization of microRNAs in oriental fruit moth Grapholita molesta and selection of reference genes for normalization of microRNA expression. by Xiu Wang, Yisong Li, Jing Zhang, Qingwen Zhang, Xiaoxia Liu, Zhen Li

“…MicroRNAs (miRNAs) are a group of endogenous non-coding small RNAs that have critical regulatory functions in almost all known biological processes at the post-transcriptional level in a variety of organisms. …”
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Genomics and proteomics of the liver fluke <em>Opisthorchis felineus</em> by V. A. Mordvinov, N. I. Ershov, O. G. Zaparina, M. Y. Pakharukova

“…Data on the O. felineus genomics and proteomics provide first insights into the structural and functional organization of the genome of this parasitic flatworm with a complex life cycle as well as provide a significant contribution to our understanding of “host-parasite” interaction and evolution of this group of parasitic flatworms.…”
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Investigating the dual role of mitochondrial and nuclear genome variants in pediatric cardiomyopathies by M. Arda Temena, Ebru Erzurumluoglu Gokalp, Ezgi Susam, Duygu Cinar, Hikmet Kiztanir, Pelin Kosger, Beyhan Durak Aras, Sevilhan Artan, Oguz Cilingir

“…Specifically, a variant in FOXRED1, encoding FAD-dependent oxidoreductase domain-containing protein-1 which functions in mitochondrial complex I stability, and another variant in cytochrome c oxidase-I, MT-CO1, crucial for aerobic metabolism, were identified in two siblings with hypertrophic cardiomyopathy. …”
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Global Longitudinal Strain: A Novel Predictor of Postoperative Outcomes in Children Undergoing Rheumatic Valve Surgery by Sowmya Kasturi, Srinath Reddy Narahari, Anand Kumar Gowdhaman, Dipesh Trivedi, Ganapathy Subramaniam, Abhinav Singh Chauhan

“…Background: Valve surgery in patients with paediatric rheumatic heart disease is challenging, owing to the complexities involved in the anatomy and hemodynamics. …”
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INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. …”
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A custom-made mouthguard reduces head acceleration during soccer heading and prevents acute electrophysiological and cognitive changes in amateur male playersResearch in context by Claire Pitteu, Philippine Lepère, Philippe Poisson, Etienne Guillaud, Emilie Doat, Bertrand Glize, Patrick Dehail, Hélène Cassoudesalle

“…Summary: Background: Repetitive head impacts related to soccer heading might lead to long-term risk of neurodegenerative diseases. …”
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The Effect of Transfusion and Hypoxia on Cells in an in vitro Model of the Neurovascular Unit by A. A. Ivkin, E. V. Grigoriev, E. D. Khilazheva, A. V. Morgun

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Integrating machine-readable user interface requirements into open networked operating rooms by Okan Yilmaz, Dominik Stegemann, Klaus Radermacher, Miriam Lange, Armin Janß

“…This has to be fulfilled by applying recognized standards such as ISO 14971 (RM) and IEC 62366-1 (UE). Addressing the complexity of use cases with multiple network participants requires defining use context, hazardous situations, user profiles, user interfaces, system function contributions, limitations, configurations, and required conditions for safe use. …”
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Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae. by Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura

“…These results strongly suggest that the host- and virus-derived secretory glycoproteins have overlapping roles in the viral life cycle of Flaviviridae, especially in the maturation of infectious particles, while Erns and NS1 also participate in replication complex formation and viral entry, respectively. Considering the abundant hepatic expression and liver-specific propagation of these apolipoproteins, HCV might have evolved to utilize them in the formation of infectious particles through deletion of a secretory viral glycoprotein gene.…”
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Study of the corrective ability of sync codes for the matched processing decoder by A. V. Sadchenko, O. A. Kushnirenko, A. G. Yurkevych, V. S. Sevastianov

“…Increase of the operation reliability of the frame synchronization schemes of communication systems affected by interferences might be achieved by using sync sequences optimal according to the minimax criterion and having the best ratio of the maximum side-lobe level to the main peak of the non-periodic autocorrelation function. …”
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Real-World Effectiveness of Single-Inhaler Triple Treatment Through Assorted Respiratory Outcomes When Switched From Multiple-Inhaler Triple Therapies (RESTART): A Prospective Coho... by Lim H, Kim DH, Hong SH, Shin J, Lee H, Shin K, Ra SW, Lee SJ

“…Despite the effectiveness of multiple inhaler triple therapy (MITT), its complexity often results in poor adherence and suboptimal outcomes. …”
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Prediction of hearing aid cognitive outcomes in age-related hearing loss by Patrice Voss, Zaida Escila Martinez-Moreno, Francois Prévost, Anthony Zeitouni, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Alejandro Lopez Valdes, Etienne de Villers-Sidani

“…Although the phenomena underlying cognitive decline and dementia are complex, there is growing evidence suggesting that degraded sensory inputs caused by age-related hearing loss may play a central role in accelerating cognitive decline in older individuals. …”
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First Iberian aspidothoracid megasecopteran insect and associated plants evidencing herbivory in a tropical Carboniferous forest from León, Spain by ARTAI A. SANTOS, ANTONIO HERNÁNDEZ-ORÚE, ENRIQUE PEÑALVER, STEPHEN MCLOUGHLIN, JOSÉ B. DIEZ

“…This diversity of interactions highlights varied feeding strategies, includ ing chewing, piercing and sucking behaviors, evidencing a more complex range of herbivory in the area than previously known. …”
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Vulnerability of long-range inputome of basal forebrain in normal aging mice by Tingting Sun, Jiale Chen, Bimin Liu, Anan Li, Hui Gong, Xiangning Li, Xiangning Li

“…The basal forebrain (BF) has been shown to have complex connections with the hippocampus (Hip) and medial prefrontal cortex (mPFC) through circuits, and is involved in cognitive functions. …”
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Tourette Syndrome in Children: An Updated Review by Jung-Chieh Du, Ting-Fang Chiu, Kun-Mei Lee, Hsin-Lin Wu, Ya-Chi Yang, Shu-Yeh Hsu, Chung-Shu Sun, Betau Hwang, James F. Leckman

“…Symptoms usually begin with simple motor or vocal tics which then evolve into more complex motor and vocal tics over time. Premonitory sensory urges are common in children over the age of 8 years, and these urges help distinguish tics from symptoms of other movement disorders. …”
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Making sense of the evidence in population health intervention research: building a dry stone wall by David Ogilvie, Jenna Panter, Adrian Bauman, David Humphreys, Louise Foley, Cornelia Guell

“…In this way we might channel a spirit of pragmatic pluralism into making sense of complex sets of evidence, robust enough to support more plausible causal inference to guide action, while accepting and adapting to the reality of the public health landscape rather than wishing it were otherwise. …”
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The surface tension and cloud condensation nuclei (CCN) activation of sea spray aerosol particles by J. Kleinheins, N. Shardt, U. Lohmann, C. Marcolli

“…In this study the cloud condensation nuclei (CCN) activity of SSA particles calculated with classical Köhler theory is compared to a more complex calculation that considers bulk–surface partitioning, surface tension lowering, and liquid–liquid phase separation. …”
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Mapping Hsp104 interactions using cross‐linking mass spectrometry by Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak

“…Recent cryo‐EM structures of AAA+ molecular machines have uncovered nuanced changes in their conformation that underlie their specialized functions. Structural knowledge of these molecular machines in complex with substrates begins to explain their mechanism of activity. …”
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An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant Escherichia coli by Manisha Aswal, Nirpendra Singh, Neelja Singhal, Manish Kumar

“…Microbial drug resistance is a complex phenomenon which is conditioned by an interplay of several genomic, transcriptomic and proteomic factors. …”
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