Dynamic regulation of neutrophil immunometabolism by platelet-derived metabolites by Manuel Alejandro Mosso-Pani, Manuel Alejandro Mosso-Pani, Dante Barreda, Ma. Isabel Salazar

“…Additionally, platelets induce metabolic reprogramming in neutrophils, affecting glycolysis and mitochondrial pathways, while also shaping the immune microenvironment by modulating other immune cells, such as T and B cells. Understanding this complex crosstalk between platelets and neutrophils—two of the most abundant cell types in the bloodstream—might reveal new therapeutic opportunities to regulate immune responses in inflammatory and immune-mediated diseases.…”
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Environmental drivers of the resistome across the Baltic Sea by Joeselle M. Serrana, Francisco J. A. Nascimento, Benoît Dessirier, Elias Broman, Malte Posselt

“…The combined effects of salinity and temperature gradients, alongside nutrient availability, created a complex environmental landscape that shaped the diversity and distribution of the predicted ARGs. …”
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EXPRESSION OF GENES ENCODING IMMUNOPROTEASOME SUBUNITS INDUCIBLE BY MACROPHAGES INFECTED WITH M. bovis BGC AND M. Tuberculosis H37RV by S. N. Andreevskaya, T. G. Smirnova, A. V. Timofeev, E. E. Larionova, L. N. Chernousova

“…It was assumed that the inhibited transcription of this subunit, when inoculated with the virulent M. tuberculosis strain, might lead to the blocked assembly of the whole immunoproteasome and to its reduced functional activity. …”
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Throwing Stick to Spear Thrower - Study of Ethnographic Artefacts and Experimentation by Luc Bordes

“…Indeed, some traditional Aboriginal hooked throwing sticks from Coopers Creek might be a trace of a prehistoric throwing stick/spear thrower technological complex which has disappeared to be replaced by true specialised spear throwers from New Guinea, rendering them obsolete. …”
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Nanosensors for Exhaled Breath Condensate: Explored Models, Analytes, and Prospects by Esther Ghanem

“…Nonetheless, conventional EBC screening methods are complex and require high operational costs and expertise. …”
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Identification of Gene Targets for the Sprouting Inhibitor CIPC by Thomas M. Grand, James K. Pitman, Alexander L. Williams, Lisa M. Smith, Andrew J. Fleming

“…This approach led to the identification of a component of the augmin complex (a core player in mitosis) as a potential target for CIPC.…”
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What Lies Inside a Dead Coral: Diversity of Reef-Associated Cryptic Crustacean (Crabs: Anomura and Brachyura) from Different Habitat Characteristics in Tidung Islands, Indonesia by Satya Pratama Atmaja, Prakas Santoso, Muhamad Gilang Arindra Putra, Fadel Muhammad, Wiwid Andriyani Lestariningsih, Beginer Subhan, Hawis Madduppa

“… • Different characteristics and complexity of coral habitat affect the dynamics of cryptic crustacean communities   Abstract   Recent studies have been widely carried out on the important role and ecological function of coral reefs. …”
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BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis by Yijin Chen, Dawei Huo, Ye Meng, Jie Zhang, Mengmeng Huang, Qian Luo, Yulin Xu, Haiqiong Zheng, Yingli Han, Xiangjun Zeng, Yanjuan Liu, Yunfei Liu, Rui Wen, Delin Kong, Ruxiu Tie, Shanshan Pei, Nan Liu, Pengxu Qian, He Huang, Meng Zhang

“…Besides, we clarify RhoB’s activity and function during terminal erythropoiesis. BRD4 inhibition might be a simple method to promote in vitro blood cell production, and a candidate therapeutic target for diseases leading to dyserythropoiesis such as myelodysplastic syndromes.…”
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Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies by M. Sicorello, J. Herzog, T.D. Wager, G. Ende, M. Müller-Engelmann, S.C. Herpertz, M. Bohus, C. Schmahl, C. Paret, I. Niedtfeld

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Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in an Ex vivo skin model by Giulia Zivelonghi, Luca Melotti, Anna Carolo, Andrea Venerando, Margherita Roncoroni, Giordana Martinelli, Lisa Maccatrozzo, Stefania Marzorati, Michela Sugni, Marco Patruno

“…IntroductionThe skin is often exposed to harmful stimuli that might compromise its integrity and functionality. …”
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Model order reduction for left ventricular mechanics via congruency training. by Paolo Di Achille, Jaimit Parikh, Svyatoslav Khamzin, Olga Solovyova, James Kozloski, Viatcheslav Gurev

“…While finite element models of the heart can naturally account for patient-specific anatomies reconstructed from medical images, optimizing the many other parameters driving simulated cardiac functions is challenging due to computational complexity. …”
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Monocephalus dipygus in a 4-month-old mixed-breed puppy: clinical, radiographic, ultrasonographic, karyotyping and surgical intervention by Lorena Elizabeth Chalco-Torres, Ana Elizabeth Guerrero López, Mauro Nirchio Tursellino

“…Notably, since each bladder was independently connected to a kidney, surgical intervention in the genitourinary system was avoided to prevent potential impairment of urinary function. This case highlights the complexity of congenital anomalies in canines and emphasizes the importance of a multidisciplinary approach to their diagnosis and management.…”
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Lower expression of miR-218 in human breast cancer is associated with lymph node metastases, higher grades, and poorer prognosis by Fereshteh Ahmadinejad, Seyed Javad Mowla, Mohammad-Amin Honardoost, Mostafa Gholami Arjenaki, Mohammad Moazeni-Bistgani, Soleyman Kheiri, Hossein Teimori

“…Despite emergence of several prognosticators for better management of patients, there are still limitations for their clinical application due to the complexity of breast tumors, and therefore, new biomarkers for better prognosis of clinical outcomes would be of the great essence. …”
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Inertial-Based Dual-Task Gait Normalcy Index at Turns: A Potential Novel Gait Biomarker for Early-Stage Parkinson’s Disease by Lin Meng, Xiaofei Zhang, Yu Shi, Xinge Li, Jun Pang, Lei Chen, Xiaodong Zhu, Rui Xu, Dong Ming

“…However, few studies have explored gait deviation evaluation algorithms under a complex dual task that reflect disease specificity. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
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Targeting senescent cells in translational medicine by Marta Paez‐Ribes, Estela González‐Gualda, Gary J Doherty, Daniel Muñoz‐Espín

“…Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. …”
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Exploring Therapists’ Approaches to Treating Eating Disorders to Inform User-Centric App Design: Web-Based Interview Study by Pamela Carien Thomas, Pippa Bark, Sarah Rowe

“…Therapists dealing with complex ED issues went beyond traditional CBT using additional therapeutic techniques and a flexible, person-centered approach to treatment. …”
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Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players by Yidong Zhang, Jiawei Zhu, Ke Hu, Jie Qiu, Fuquan Zhang, Fuquan Zhang

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The Neuroprotective Effect of the Association of Aquaporin-4/Glutamate Transporter-1 against Alzheimer’s Disease by Yu-Long Lan, Shuang Zou, Jian-Jiao Chen, Jie Zhao, Shao Li

“…Moreover, the colocalization of AQP4 and GLT-1 has long been studied in brain tissue; however, far less is known about the potential influence that the AQP4/GLT-1 complex may have on AD. Research on the functional interaction of AQP4 and GLT-1 has been demonstrated to be of great significance in the study of AD. …”
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Sport-Orthopädie by Kraus K, Doyscher R, 3, Schütz E

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