Exploring Molecular Pathways in Refractive Errors Associated with Inherited Retinal Dystrophies by Fabiana D’Esposito, Caterina Gagliano, Alessandro Avitabile, Giuseppe Gagliano, Mutali Musa, Matteo Capobianco, Federico Visalli, Edoardo Dammino, Marco Zeppieri, Maria Francesca Cordeiro

“…However, the prevalence statistics might differ significantly depending on the exact type of dystrophy and the demographic being examined. …”
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. by Dan Su, Xuting Wang, Michelle R Campbell, Devin K Porter, Gary S Pittman, Brian D Bennett, Ma Wan, Neal A Englert, Christopher L Crowl, Ryan N Gimple, Kelly N Adamski, Zhiqing Huang, Susan K Murphy, Douglas A Bell

“…Tobacco smoke exposure dramatically alters DNA methylation in blood cells and may mediate smoking-associated complex diseases through effects on immune cell function. …”
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The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression by Cong He, Baojiang Chen, Hecai Yang, Xiaoqing Zhou

“…Despite extensive research, the role of microglia in AD remains complex and dual. The aim of this review is to summarize the most recent advances in research regarding the dual role of microglia in AD concerning both immunomodulation and pathological progression by considering mechanisms of activation of microglia, effects on Aβ clearance, tau pathology, and impacts due to genetic variations on microglial functions. …”
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Assessment of Classical Force-Fields for Graphene Mechanics by Zhiwei Ma, Yongkang Tan, Xintian Cai, Xue Chen, Tan Shi, Jianfeng Jin, Yifang Ouyang, Qing Peng

“…Molecular dynamics simulation is a well-established and useful tool for investigating graphene’s atomic structure and dynamic behavior at the nanoscale without requiring expensive and complex experiments. The accuracy of the molecular dynamics simulation depends on the potential functions. …”
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Solar Biota. Co-Living with Solar Ecologies by Suzanna Törnroth

“…The article culminates in the explanation of ‘solar ecologies’, which offers a point of departure in exploring relational complexities in co(living) with solar PV – and solar energy symbolically, at large.…”
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A high throughput method for isolation of plasmatocytes from hemolymph of adult Drosophila. by Mansi Yadav, Jassika Gupta, Debalina Chatterjee, Parul Mittal, Anju Shrivastava, Namita Agrawal

“…Macrophages are essential innate immune system components, exhibiting diverse functions crucial for disease prevention. While much is known about their role in innate immunity, studying their functional versatility remains a challenge. …”
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Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli by Martina Rudgalvyte, Zehan Hu, Dieter Kressler, Jörn Dengjel, Dominique A Glauser

“…These findings highlight a complex interplay of signaling modules that modulate thermal nociception and adaptation, offering new insights into potentially conserved mechanisms that shape nociceptive plasticity and pain (de)sensitization in more complex nervous systems.…”
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SOX7: Autism associated gene identified by analysis of multi-Omics data. by Samantha Gonzales, Jane Zizhen Zhao, Na Young Choi, Prabha Acharya, Sehoon Jeong, Xuexia Wang, Moo-Yeal Lee

“…Thus, it is unclear which of these mutations might be functional and thus potentially causal variants. …”
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Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms. by Denise Locatelli, Mineko Terao, Mami Kurosaki, Maria Clara Zanellati, Daniela Rita Pletto, Adele Finardi, Francesca Colciaghi, Enrico Garattini, Giorgio Stefano Battaglia

“…However, to what extent the impairment of these two SMN functions contributes to SMA pathogenesis remains unknown. …”
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Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. by Leonie Unterholzner, Rebecca P Sumner, Marcin Baran, Hongwei Ren, Daniel S Mansur, Nollaig M Bourke, Felix Randow, Geoffrey L Smith, Andrew G Bowie

“…However, C6 does not inhibit TBK1- and IKKε-independent IRF7 activation or the induction of promoters by constitutively active forms of IRF3 or IRF7, indicating that C6 acts at the level of the TBK1/IKKε complex. Consistent with this notion, C6 immunoprecipitated with the TBK1 complex scaffold proteins TANK, SINTBAD and NAP1. …”
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Urotensin-II: More Than a Mediator for Kidney by Ayşe Balat, Mithat Büyükçelik

“…Since there is a complex relationship between U-II and oxidative stress, and other mediators, such as transforming growth factor β1 and angiotensin II, U-II is more than a mediator in glomerular diseases. …”
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Case report: Clinical and genetic characteristics of heterozygous CaSR variants in three Chinese females with familial hypocalciuric hypercalcemia type 1: a report of three cases by Ruxuan Zhang, Ruxuan Zhang, Tingting Hu, Shuai Wang, Yiping Cheng, Dandan Luo, Dongmei Zheng, Xinli Zhou, Xinli Zhou, Xinli Zhou

“…The analysis of the conservation of homologous species and the prediction of protein structure for all variant sites demonstrated that due to the heterozygous variants in CaSR, relatively conserved amino acids were altered, affecting the interaction forces between adjacent amino acids, resulting in changes in the protein structure, which might affect the function of the protein.ConclusionIn conclusion, we report three cases of FHH1 with different heterozygous variant sites in the CaSR gene. …”
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Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development by Chao Yang, Lingxi Zhu, Li Tang, Xiangyu Zhang, Min Lei, Xiaohong Xie, Cuixia Zhang, Dingsheng Yuan, Congyan Li, Ming Zhang

“…GO (Gene Ontology) analysis of DEGs indicated DEGs in the thigh muscle were enriched in these terms related to biological processes of muscle cell migration and smooth muscle cell migration, cellular components of sarcomere, myofibril, and actin filament bundle, while DEGs in <i>longissimus dorsi</i> muscle were enriched in these terms associated with biological processes of muscle cell migration, smooth muscle cell migration and muscle structure development, cellular component of actin cytoskeleton, contractile fiber, myofibril, myosin complex and molecular function of actin filament binding. …”
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Screening and Analysis of Proteins Interacting with TaPDK from Physiological Male Sterility Induced by CHA in Wheat by Long-yu ZHANG, Gai-sheng ZHANG, Xin-liang ZHAO, Shu-ling YANG

“…Collectively, these datas indicated that the majority of candidate proteins might be related to pollen abortion in PHYMS lines, which further suggested that TaPDK plays multiple roles in pollen development, besides participating in regulating pyruvate dehydrogenase complex activity.…”
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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…Abstract Background Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. …”
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An Insight on Gut Flora, Colorectal Cancer Mechanism, and Treatment Strategies by Rajendra Kumar, Ashmeen Kaur, Divyanshu Rajput

“…The complex interplay of tumour cells, nonneoplastic cells, and a large variety of microbes results in colorectal cancer. …”
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Identification of Potential Inhibitors Targeting Non-Structural Proteins NS3 and NS5 of Dengue Virus Using Docking and Deep Learning Approaches by Alomgir Hossain, Faria Tasnin Joti, Md. Shohag Hossain, Abdullah Al-Noman, Chomong Thowing, Mehjabin Mursona, Md. Robiul Islam, Md. Ekhtiar Rahman, Mohammad Nurul Matin, Md Azizul Haque

“…Our identified new drug candidates might help for developing effective antiviral inhibitors against the DENV. …”
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Unraveling the source of corrosive microorganisms from fracturing water to flowback water in shale gas field: evidence from gene sequencing and corrosion tests by Yanran Wang, Shaomu Wen, Shibo Zhang, Yongfan Tang, Xi Yuan, Fang Guan, Fang Guan, Jizhou Duan

“…As an insidious and often underestimated phenomenon, microbially influenced corrosion (MIC) poses a significant threat to the integrity and longevity of oil and gas pipelines. However, the complex corrosive microorganisms, that might induce MIC in underground pipelines, might be introduced by the fracturing water during the production period, or they may also exist in the native corrosive microbial community underground. …”
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Alzheimer's Disease: Another Target for Heparin Therapy by Luigi Bergamaschini, Emanuela Rossi, Carlo Vergani, Maria Grazia De Simoni

“…The complexity of AD pathology provides numerous potential targets for therapeutic interventions. …”
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Beyond awareness: the binding of reflexive mechanisms with the conscious mind: a perspective from default space theory by Ravinder Jerath, Connor Beveridge

“…How do reflexes operate so quickly with so much multimodal information on the environment? How might unconscious processes help reveal the nature of consciousness? …”
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