The commonly used antibiotic streptomycin reduces protein synthesis and differentiation in cultured C2C12 myotubes by Chuqi He, Moritz Eggelbusch, Jelle Y. Huijts, Andi Shi, Gerard J. deWit, Carla Offringa, Richard T. Jaspers, Rob C. I. Wüst

“…Because streptomycin inhibits bacterial protein synthesis, streptomycin might also have off‐target effects on muscle cell function. …”
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Infection with novel duck reovirus induces stress granule and methylation-mediated host translational shutoff in Muscovy ducklings by Tao Yun, Jionggang Hua, Liu Chen, Weicheng Ye, Zheng Ni, Yinchu Zhu, Cun Zhang

“…We found that both in vivo and in vitro, the translation efficiency of RNA modified with m6A could be significantly reduced by σB, a structural protein component of NDRV HN10. Furthermore, σB might simultaneously interact with the stress granule complex CAPRIN1 and G3BP1 and the m6A reader protein YTHDF1/3. …”
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Quantitative Assessment of the Uncertainty in Aerosol Optical Property Inversion due to Different Surface Reflection Models by Haoling Zhang, Lei Li, Xindan Zhang, Ke Gui, Yu Zheng, Huizheng Che

“…Uncertainties in AAOD and SSA retrievals are more complex, with the RPV model producing higher AAOD values in southern Europe and western North America. …”
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Photometric Determination of Unresolved Main-sequence Binaries in the Pleiades: Binary Fraction and Mass-ratio Distribution by Rongrong Liu, Zhengyi Shao, Lu Li

“…The variations of f _b and q with ${{ \mathcal M }}_{1}$ reveal a complex binary distribution within the Pleiades, which might be attributed to a combination of primordial binary formation mechanisms, dynamical interactions, and the observational limit of photometric binaries imposed by ${q}_{{\rm{lim}}}({{ \mathcal M }}_{1})$ .…”
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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
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Features of blocking HLA-DR and HLA-G BY the human IgG fraction from the plasma of multiparous women by A. V. Shabaldin, N. S. Deeva, A. S. Sukhikh, G. V. Vavin

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EMOTIVE SPEECH ACTS IN CROSS-CULTURAL COMMUNICATION: A COMPREHENSIVE ANALYSIS AND EXPERIMENTAL STUDY by Kenul E. Abdurehmanova

“…The aim of the study is to determine the role of emotive speech acts in cross-cultural language learning environments, revealing the complex interplay between universal emotional markers and culturally specific expression patterns. …”
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Effect of core wettability on seepage characteristics during CO2 saline aquifer sequestration process by MEIHERIAYI Mutailipu, Fusheng XUE, Tao LI, Yanjing LI, Yu LIU

“…For anisotropic wettability, the displacement process was more complex, and its influence on relative permeability and residual saline water saturation varied. …”
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Mitochondrial RNA maturation by Zofia M. Chrzanowska-Lightowlers, Robert N. Lightowlers

“…These processes are sometimes driven by the unusual behaviour of the mitochondrial genome from which the RNA is originally transcribed, but in many examples the complex processes that are essential for the production of functional RNA in the organelle, are fascinating and bewildering.…”
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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis

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Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats by Andreas V. Madsen, Peter Kristensen, Alexander K. Buell, Steffen Goletz

“…The formation of bsAbs is, however, often dependent on complex engineering strategies with a high risk of antibody chain mispairing leading to contamination of the final product with incorrectly assembled antibody species. …”
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Differing evolutionary histories of the ACTN3*R577X polymorphism among the major human geographic groups. by Carlos Eduardo G Amorim, Victor Acuña-Alonzo, Francisco M Salzano, Maria Cátira Bortolini, Tábita Hünemeier

“…It has been proposed that the functional ACTN3*R577X polymorphism might have evolved due to selection in Eurasian human populations. …”
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A double-edged sword in antiviral defence: ATG7 binding dicer to promote virus replication by Yaotang Wu, Yang Wu, Chenlu Wang, Ningna Xiong, Wenxin Ji, Mei Fu, Junpeng Zhu, Zhixin Li, Jian Lin, Qian Yang

“…Our findings suggested that virus infection might trigger the upregulation of autophagy and downregulation of the RNAi pathway, revealing a complex interaction between these two biological processes in the defence against viral replication.…”
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Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration by Kimberly Hernandez, Caitlin H Nguyen, Girdhari Rijal

“…Complexities in cell-cell and cell-matrix interactions, and different in types and ratios of ECM proteins in a TME challenge to reveal the precise function of a particular protein that is exhibited by special cells and if specifically present in insignificant amount. …”
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Human Development XIII: The Connection Between the Structure of the Overtone System and the Tone Language of Music. Some Implications for Our Understanding of the Human Brain by Søren Ventegodt, Tyge Dahl Hermansen, Isack Kandel, Joav Merrick

“…The functioning brain behaves like one highly-structured, coherent, informational field. …”
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Kinesthetic illusions induced by muscle tendon vibration: The orientation of the vibration motor as a new methodological factor? by Lydiane Lauzier, Jacques Abboud, François Nougarou, Louis-David Beaulieu

“…Distoproximal rotation was more effective to elicit the expected illusions of wrist extension, compared to the lateromedial orientation that more often caused complex and variable perceptions of movement. Distoproximal rotation should thus be preferred if clear and reproducible perceptions are required and lateromedial might serve as a way of creating illusions more akin to everyday functional movements. …”
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Fetal and neonatal cardiac tumor diagnosed as Tuberous Sclerosis associated rhabdomyomas resulting from novel pathogenic missense variant detected in TSC2 gene: A case report by Aya Kawasaki, MD, Hidefumi Tonoki, MD, PhD, Osamu Sasaki, MD, PhD, Yoko Matsushita, MD, PhD, Michiko Watari, MD, PhD, Nobuhiro Takahashi, MD, Satoko Fujieda, MD

“…This pathogenic variant is located on exon 10 of the TSC2 gene, which encodes the hamartin binding domain, leading to impair inhibitory function of the hamartin-tuberin complex, which activates mammalian target of rapamycin(mTOR) activity. …”
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Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation by Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin, Xu Lin

“…Since BAF155 has been shown to stabilize other members of the SWI/SNF chromatin remodelling complex by attenuating their proteasomal degradation, we proposed that BAF155 might also contribute to stabilizing HBx protein in a proteasome-dependent manner. …”
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Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures by Nicola Riccardo Pugliese, Francesco Paneni, Domenico Tricò, Alessandra Violet Bacca, Nicolò De Biase, Hermann Dalpiaz, Alessandro Mengozzi, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Reinhold Kreutz, Konstantinos Tsioufis, Stefano Masi

“…While overweight/obesity increases the risk of developing HF, its impact on patient outcomes remains complex. The “obesity paradox” suggests that a higher BMI may be associated with improved survival in patients with established HF. …”
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Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface by Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco

“…Results: Simulations report poor affinity of CD2v to CD58 in the "canonical" pose and present a novel pose backed by docking, simulation data, and recent observations. The new site might have developed due to immunological considerations and may reproduce observed lymphocyte non-proliferation by hijacking CD58-CD2 ruler functions in immunological synapse formation. …”
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