Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports by Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang

“…By disrupting histone-DNA contacts, this complex modulates gene expression patterns, and accumulating evidence suggests its tumor suppressor function. …”
Get full text

TNFα levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. by Alessia Franceschini, Sandra Vilotti, Michel D Ferrari, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti

“…Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. …”
Get full text

Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. by Thomas J Carney, Natália Martins Feitosa, Carmen Sonntag, Krasimir Slanchev, Johannes Kluger, Daiji Kiyozumi, Jan M Gebauer, Jared Coffin Talbot, Charles B Kimmel, Kiyotoshi Sekiguchi, Raimund Wagener, Heinz Schwarz, Phillip W Ingham, Matthias Hammerschmidt

“…In addition, the novel genes might prove helpful to unravel the molecular nature of thus far unresolved cases of the human disease.…”
Get full text

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. by Jennifer H Stuart, Rebecca P Sumner, Yongxu Lu, Joseph S Snowden, Geoffrey L Smith

“…Here we show that vaccinia virus (VACV) strain Western Reserve protein C6, is a dual function protein that inhibits the cellular response to type I IFNs in addition to its published function as an inhibitor of IRF-3 activation, thereby restricting type I IFN production from infected cells. …”
Get full text

Magnetite particle size and spatial distribution may modulate neural oscillation in the human brain by Gunther Kletetschka, Robert Bazala

“…This work provides a theoretical approach for future experimental studies and may offer new perspectives on the complex dynamics of brain physiology and pathology.…”
Get full text

EgoCor: An R Package to Facilitate the Use of Exponential Semi-Variograms for Modelling the Local Spatial Correlation Structure in Social Epidemiology by Julia Dyck, Jan-Ole Koslik, Odile Sauzet

“…Existing tools for the analysis of spatial data in R might appear too complex to non-specialists which could limit the use of the approach. …”
Get full text

Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…As far as we know, no aqueduct had yet come into operation at that time. Conversely, it might have received its water supply from the Yzeron aqueduct at the time when the complex was transformed during the reigns of Tiberius and Claudius. …”
Get full text

Unconventional T Cells’ Role in Cancer: Unlocking Their Hidden Potential to Guide Tumor Immunity and Therapy by Paola Pinco, Federica Facciotti

“…The complex crosstalk between UC T cells and the surrounding factors is discussed in this review, with a focus on how these cells might be interesting candidates to explore and exploit as anticancer therapeutic agents. …”
Get full text

How Much Rationality Is Needed for Decision Making? by Annette Grathoff

“…With the perspective that the evolution of information processing systems is already beginning in a physical and chemical pre-biotic world, this is an interesting case that might give further insight into how and when choices between many possibilities could threaten the function of a system rather than making it more durable and adaptable. …”
Get full text

A Norwegian cohort with STAT1-related disease – further expanding the clinical phenotype by Karen Helene Bronken Martinsen, Karen Helene Bronken Martinsen, Torstein Øverland, Asbjørg Stray-Pedersen, Tore G. Abrahamsen, Børre Fevang, Børre Fevang, Hans Christian Erichsen Landsverk, Hans Christian Erichsen Landsverk

“…Presently, our cohort represents the largest nationwide study on STAT1-related disease.ConclusionWe report novel clinical manifestations in STAT1 GOF, and suggest that heterozygous STAT1 LOF might be a more complex condition than originally presumed.…”
Get full text

Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity by Fernanda Raiqueo, Roberto Amigo, José L. Gutiérrez

“…In the yeast Saccharomyces cerevisiae, Reb1 and Abf1 are among the transcriptions factors that perform this molecular function. These factors are thought to act as a barrier to nucleosome sliding that chromatin remodeling complexes such as ISW1a perform towards this region, being binding affinity a critical feature to act as a barrier. …”
Get full text

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. by Anna Ghelli, Anna Maria Porcelli, Claudia Zanna, Sara Vidoni, Stefano Mattioli, Anna Barbieri, Luisa Iommarini, Maria Pala, Alessandro Achilli, Antonio Torroni, Michela Rugolo, Valerio Carelli

“…Recently it was also documented that the professional exposure to n-hexane might act as an exogenous trigger for LHON. Therefore, we here investigate the effect of the n-hexane neurotoxic metabolite 2,5-hexanedione (2,5-HD) on cell viability and mitochondrial function of different cell models (cybrids and fibroblasts) carrying the LHON mutations on different mtDNA haplogroups. …”
Get full text

Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis by Jonás Carmona-Pírez, Rocío Salsoso, Eléna Charpentier, Cinta Olmedo, Francisco J. Medrano, Lucas Román, Carmen de la Horra, Yaxsier de Armas, Enrique J. Calderón, Vicente Friaza

“…We found 11 protein complexes, notably the JAK-STAT signaling complex in non-colonized IPF patients. …”
Get full text

Deciphering algorithmic collusion: Insights from bandit algorithms and implications for antitrust enforcement by Frédéric Marty, Thierry Warin

“…Legally, the primary challenge lies in detecting and categorizing possible algorithmic signals, particularly when they function as unilateral communications. Economically, the task of distinguishing between rational pricing strategies and collusive patterns becomes increasingly complex in the context of algorithm-driven decisions. …”
Get full text

Pills, Power and Performativity: Negotiating Masculinity in the Emergence of Male Contraceptive Technology by Eleonore Lorijn

“…Specifically, I seek to understand how contraceptive technology might contribute to the emergence and transformation of different masculine identities, and whether these identities will function to enhance or denounce the technology's cultural feasibility and widespread assimilation. …”
Get full text

Anesthetic challenges in a cardiac patient undergoing noncardiac surgery by Vaishali S Badge, Pankaj Patil

“…He developed hyphema in the right eye due to long-standing uncontrolled diabetes with complete loss of vision. This case was very complex to manage as the patient had comorbidities with low EF. …”
Get full text

Developing approaches to treating arterial hypertension in regard to possible pathways of angiotensin II synthesis by N. M. Chikhladze, N. V. Lebedeva, L. A. Belova, G. N. Litonova, E. B. Yarovaya, I. E. Chazova

Get full text

Identification of SURF4 and RALGAPA1 as promising therapeutic targets in glioblastoma and pan-cancer through integrative multi-omics, CRISPR-Cas9 screening and prognostic meta-anal... by Fei Wang, Yuxuan Chen, Run Huang, Dengfeng Lu, Juyi Zhang, Yanbo Yang, Hanhan Dang, Meirong Liu, Zhouqing Chen, Xiaoou Sun, Zhong Wang

“…GBM multi-omics data from public and in-house cohorts validated that CD44 and SURF4 might be synthetic lethal partners of loss-of-function tumor suppressor genes. …”
Get full text

Presentation and physical therapy management using a neuroplasticity approach for patients with hypermobility-related upper cervical instability: a brief report by Susan Chalela, Susan Chalela, Leslie N. Russek, Leslie N. Russek

“…UCI can impact various neurological structures, including the brainstem, spinal cord, cranial nerves, and blood supply to and from the brain, resulting in complex neurological signs and symptoms in this population. …”
Get full text

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10. by Jacopo Lucchetti, Marianna Marino, Simonetta Papa, Massimo Tortarolo, Giovanna Guiso, Silvia Pozzi, Valentina Bonetto, Silvio Caccia, Ettore Beghi, Caterina Bendotti, Marco Gobbi

“…Recently, the coenzyme-Q (CoQ) complex, a key component of mitochondrial function and redox-state modulator, has raised interest for ALS treatment. …”
Get full text