Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target by Wu Di, Wu Di, Li Minghan, Li Minghan, Huang Zining, Zhou Chunshi, Hu Xiangyu, Wang Zidong, Wu Gang, Wu Gang, Wu Gang

“…We provide the first evidence of a direct interaction between TP and PTHrP, suggesting a novel mechanism through which TP may disrupt PTHrP-mediated osteoclast activation. …”
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Climate walking: A comparison study of mobile weather stations and their relevance for urban planning, design, human health and well-being by T. Silva, R. Ramusga, M. Matias, J. Amaro, A. Bonifácio, C. Reis, A. Chokhachian, G. Lopes, A. Almeida, J. Frazão, J. Vasconcelos, A. Lopes, P. Morgado

“…Microclimate conditions affect the outdoor urban way of life for humans. These conditions directly impact people’s health and well-being, such as access to medical care or a healthy lifestyle. …”
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AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy by Xueyan Liu, Jiexin Xu, Shuping Zheng, Yaoyao Yang, Yuchong Xie, Jinyu Liu, Jian Zhong, Huiyao Zhang, Jiajing Chen, Chaoxian Dai, Dingyan Wang, Jiewei Luo, Xiaochun Chen, Feisheng Zhong, Zu-Cheng Ye

“…Following AI-based virtual screening and structure prioritization, FJMU1887 demonstrated direct binding to Gal-3 with an affinity (Kd) of 1.55 μM, determined by microscale thermophoresis (MST). …”
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Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer by Lorenzo Castagnoli, Francesco Bonì, Martina Bigliardi, Paolo Toneguzzo, Paola A. Corsetto, Giorgia Galasso, Alma Franceschini, Paolo Cocomazzi, Viola Regondi, Cristian Capuzzoni, Angela M. Rizzo, Francesca Ligorio, Claudio Vernieri, Pierfausto Seneci, Daniela Arosio, Elda Tagliabue, Eloise Mastrangelo, Mario Milani, Serenella M. Pupa

“…FASN is overexpressed/activated in most HER2 + BC cells sustaining their growth, proliferation, and aggressiveness through a reciprocal direct interplay with the HER2-driven oncogenic signaling. …”
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Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation by Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li

“…The findings clarify the direct targets and signaling mechanisms underlying the anti‐inflammatory effects of bilirubin and pave the way for exploring its novel functions.…”
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Experimental Study on Mechanical Properties of Lime-Basalt Fiber Modified Red Mudstone Filler by XIAO Pan, LIN Pengjie, CHEN Nan, WANG Wen, LIU Jia, LIU Xianfeng

“…To mitigate this, basalt fibers are incorporated, which could effectively reduce the brittleness of the lime modified red mudstone filler(LMRM).This study focuses on the mechanical properties analysis of lime-basalt fiber modified red mudstone filler(LFMRM). Specifically, direct shear tests were conducted on samples with varying basalt fiber contents ( 0%, 0.1%, 0.2%, 0.3%, 0.4% ) to elucidate the effects on shear strength, dilatancy, and brittleness, under that the lime content was fixed at 4%, and the compaction degree reached 95% ( dry density was 1.67 g/cm³ ),in 7 days maintenance. …”
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High-resolution temperature profiling in the Π Chamber: variability of statistical properties of temperature fluctuations by R. Grosz, K. K. Chandrakar, R. A. Shaw, J. C. Anderson, W. Cantrell, S. P. Malinowski

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The Relationship between Temperament and Character with Wisdom Through Cognitive Regulation Strategies of Emotion by Fahime Naseri, Yasser Azizisaeid

“…Positive emotion regulation strategies had a greater effect on wisdom than negative strategies. Also, the direct and indirect relationships between temperament and character and wisdom were confirmed. …”
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