Unveiling the anticancer potential of Curcuma amada rhizome extract against prostate cancer through computational and experimental approaches by Arpita Priyadarshini, Debajani Mohanty, Swagat Mohanty, Rout George Kerry, Ambika Sahoo, Biswabhusan Dash, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray, Sudipta Jena

“…Curcuma amada extract has demonstrated antitumor properties in preclinical models of various cancers, however, its mechanisms against prostate cancer remain unclear. …”
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Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration... by Sheng Li, Shiyi Lu, Jiahui Xiong, Liang Chen, Yanting Lin, Xiaohui Chen, Xinyi Wang, Lijing Lin, Xiaoliang Cai, Xiaoyu Yang

“…Antibiotic intervention partially attenuated the therapeutic effects of the HES-CUR NPs, confirming that their effects involved microbiota-dependent mechanisms. Compared to CUR and SASP, HES-CUR NPs exhibited significantly enhanced bioavailability and efficacy (p < 0.01), attributed to the targeted delivery and sustained-release properties of the hydroxyethyl starch nanocarrier. …”
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Nanoparticles induced cuproptosis to enhance antitumor immunotherapy by Wen Deng, Zichen Zhong, Haojie Shang, Yonghua Tong, Qiu Huang, Yu He, Jian Wu, Xiaozhuo Ba, Zhiqiang Chen, Yuan Chen, Kun Tang

“…Recently, many unique physicochemical properties of nanoparticles have been designed as nano-inducers of cuproptosis, successfully enhancing immunotherapy. …”
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Emergence of steady quantum transport in a superconducting processor by Pengfei Zhang, Yu Gao, Xiansong Xu, Ning Wang, Hang Dong, Chu Guo, Jinfeng Deng, Xu Zhang, Jiachen Chen, Shibo Xu, Ke Wang, Yaozu Wu, Chuanyu Zhang, Feitong Jin, Xuhao Zhu, Aosai Zhang, Yiren Zou, Ziqi Tan, Zhengyi Cui, Zitian Zhu, Fanhao Shen, Tingting Li, Jiarun Zhong, Zehang Bao, Liangtian Zhao, Jie Hao, Hekang Li, Zhen Wang, Chao Song, Qiujiang Guo, H. Wang, Dario Poletti

“…Furthermore, by utilising precise controls and measurements with single-site resolution, we demonstrate the capability to tune steady currents by manipulating the macroscopic properties of the baths, including filling and spectral properties. …”
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High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutama... by Mohamad Reza Kordi, Nooshin Khademi, Amir Mohammad Zobeydi, Samane Torabi, Esmaeil Mahmoodifar, Abbasali Gaeini, Siroos choobineh, Parisa Pournemati

“…Objective(s): Alzheimer’s disease (AD) is a major public concern and one of the primary types of dementia characterized by memory impairment and cognitive decline. Although the properties of exercise training and cannabidiol (CBD) treatments for improving AD have recently been revealed, the exact mechanisms remain unknown. …”
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Potential role of nanostructured lipid carrier as cutting-edge approach for drug delivery of nonsteroidal anti-inflammatory drugs by Zahoor Ishrat, Singh Sukhbir, Sharma Neelam, Wani Shahid Nazir, Kishore Ladli

“…Nanocarriers have demonstrated significant importance as delivery systems because of their small size and unique properties and have shown numerous benefits, such as safeguarding the drug from environmental factors like moisture, physiological pH and enzymes. …”
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Halophyte-derived nanoparticles and biostimulants for sustainable crop production under abiotic stresses by Rekha Agrawal, Soumya Koippully Manikandan, Maria Hasnain, John Klironomos, Mohamed S. Sheteiwy, Ali El-Keblawy

“…Halophytes, inherently adapted to extreme environments, offer valuable insights into stress tolerance mechanisms and serve as promising sources for nanoparticle (NPs) and biostimulant development. …”
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Environmental Factors, Not Biotic Competitive Interactions, Drive the Relative Abundance of Diatoms and Chlorophyta in the Coastal Areas of the Beibu Gulf: Evidence From 18S rDNA M... by Chunyan Peng, Yuyue Qin, Ying Liu, Dan Sun, Zongsheng Xie, Jixin Jia, Haochen Li, Xiaobo Liu, Hongming Cao, Bin Gong

“…According to the results, the mechanisms behind the negative correlation between Chlorophyta and Diatoms varied across different seasons. …”
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Comparative Preclinical Evaluation of the Safety, Antifungal Activity, and Pharmacokinetics of Sertaconazole Products for External Use by V. M. Kosman, M. V. Karlina, V. A. Vavilova, K. E. Borovkova, K. L. Kryshen, N. V. Marchenko, S. A. Kopatko, I. V. Sychkova, D. R. Kargopoltseva, M. N. Makarova, V. G. Makarov

“…With its synergistic dual mechanism of action, broad-spectrum antifungal activity, lipophilic properties, and low systemic absorption, Sertaverin® may provide a more effective and safe alternative to marketed medicinal products for scalp diseases.…”
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Chlorogenic acid alleviates IPEC-J2 pyroptosis induced by deoxynivalenol by inhibiting activation of the NF-κB/NLRP3/caspase-1 pathway by Yanmei Xue, Fuchang Li, Rui Li, Xinru Zhang, Huijun Guo, Chunyang Wang

“…Chlorogenic acid (CGA) is an active polyphenol found in some plants, which has anti-inflammatory and antioxidant properties and a protective effect on animal intestinal health. …”
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Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress by Jing Chen, Disheng Feng, Rui Zhu, Hua Li, Lixia Chen

“…Future research should focus on optimizing KEAP1 ligand properties and exploring novel protein targets amenable to degradation via KEAP1 recruitment to further advance this innovative therapeutic modality.…”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…Given its clinically protective properties, continued investigation into the potential long-term impact of TTR suppression via knockdown or gene editing therapies is prudent. …”
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Antidepressant-like effect of Entada Africana Guill. & Perr. (Fabaceae) in mice: Involvement of monoamine neurotransmitters, cortisol, BDNF, and oxidative stress by M.Y. Bebeji, A.H. Yaro, A.R. Abubakar, M.H. Ahmad, A.B. Nazifi, A.A.E. Ahmed

“…Previous research reported its antidepressant properties in acute depression models. However, its activity in chronic model and the associated signaling pathways remain unclear. …”
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An engineering model for creeping flame spread over idealized electrical wires in microgravity by Coimbra, Alain, Li, Yutao, Guibaud, Augustin, Citerne, Jean-Marie, Legros, Guillaume, Consalvi, Jean-Louis

“…The flame spread rate (FSR) is controlled by two model parameters, which are measurable from intrinsic material and ambient gas properties: the convective flame heat flux transferred to the solid ahead from the flame front and the gaseous thermal heat length near the flame front. …”
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Increasing ECM tree dominance enhances soil lignin phenols but suppresses microbial necromass contribution to soil organic carbon in a subtropical mountainous forest by Mengzhen Lu, Long Chen, Qiuxiang Tian, Qing He, Mi Yang, Zhiyang Feng, Feng Liu

“…Plant, soil, and microbial properties were analyzed to explore the underlying mechanisms influencing SOC components across different mycorrhizal types. …”
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Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases by Sun C, Chen J, Bai S, Liao W, Chen J, Guo W, Zeng L, Yu L

“…Nevertheless, clinical translation of TCM is often limited by poor pharmacokinetic properties, including low solubility, rapid clearance, and inadequate biomembrane permeability. …”
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Evaluation of the Antifungal Activity of Clove and Cinnamon Essential Oils against Candida Albicans by Ismail, H. Y., Mustapha, A., Ngoshe, I. Y., Musa Ibn Abbas, Adamu, A., Shettima, A. L., Dan-Iya, S. A.

“…Further research into their mechanisms of action, including effects on biofilm formation and cell membrane integrity, is warranted. …”
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Innovative approaches to combat antibiotic resistance: integrating CRISPR/Cas9 and nanoparticles against biofilm-driven infections by Abolfazl Saffari Natanzi, Mohsen Poudineh, Elham Karimi, Azad Khaledi, Hamed Haddad Kashani

“…This review explores the synergistic integration of CRISPR/Cas9 and nanoparticles in combating biofilm-associated antibiotic resistance. We discuss the mechanisms of action, recent advancements, and current challenges in translating this approach into clinical practice. …”
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The influence of vaginal microbiota on ewe fertility: a metagenomic and functional genomic approach by Edgar L. Reinoso-Peláez, María Saura, Carmen González, Manuel Ramón, Jorge H. Calvo, Magdalena Serrano

“…While the overall microbiota showed a subtle effect on pregnancy, certain genera had a significant negative impact, likely due to pathogenic or inflammatory properties that disrupt reproductive health. The metagenomic approach used here enabled not only comprehensive taxonomic classification but also detailed functional analysis, providing deeper insights into the microbiome’s role in reproductive outcomes. …”
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Microaccelerometer on Surface Acoustic Waves with a Ring Resonator on Anisotropic Material by Dmitry P. Lukyanov, Alexander M. Boronakhin, Sergey Yu. Shevchenko, Mariya A. Khivrich, Temurmalik A. Amirov

“…This imposes a limitation both on the accelerometer design and the properties of materials from which these devices are produced.Aim. …”
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