Complete Androgen Insensitivity Syndrome in a Young Girl with Primary Amenorrhea and Suspected Delayed Puberty: A Case-Based Review of Clinical Management, Surgical Follow-Up, and... by Barbara Fraccascia, Giorgio Sodero, Lucia Celeste Pane, Elena Malavolta, Caterina Gola, Luigi Pane, Valentina Filomena Paradiso, Lorenzo Nanni, Donato Rigante, Clelia Cipolla

“…<i>Conclusions:</i> Primary amenorrhea and delay in puberty development may provide clues, ultimately leading to a diagnosis of CAIS. …”
Get full text

Network toxicology and molecular docking reveal the potential link between acrylamide exposure and breast cancer by Zhaoda Duan, Chunjiao Yu, Wenjie Yang, Wenhui Wang, Qi Zhang, Qiaoling Ruan, Rui Zhang, Yongfang Zhao, Shan Yan

“…These findings suggest that ACR may interfere with BC-related molecular mechanisms through multi-target and multi-pathway interactions, providing theoretical evidence for its potential carcinogenic role and future risk assessment.…”
Get full text

USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway by Ni Xiong, Yue Wang, Junhong Jiang

“…Materials & Methods This work utilized single‐cell transcriptomic analysis with the Scissor algorithm to identify distinct epithelial subpopulations, particularly focusing on the Stress subpopulation that exhibited significant upregulation of USP5. …”
Get full text

The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics... by Jianhang Du, Guangyao Wu, Bokai Wu, Chang Liu, Zhouming Mai, Yumeng Liu, Yawei Wang, Pandeng Zhang, Guifu Wu, Jia Liu

“…To quantify the effect of EECP intervention on arterial hemodynamic environment, a framework of numerical assessment was introduced using a parallel computing algorithm. A 3D endothelial surface of the carotid artery with mild atherosclerotic plaque was constructed from images of magnetic resonance angiography (MRA). …”
Get full text

Versatile cataract fundus image restoration model utilizing unpaired cataract and high-quality images by Zheng Gong, Zhuo Deng, Weihao Gao, Wenda Zhou, Yuhang Yang, Hanqing Zhao, Lei Shao, Wenbin Wei, Lan Ma

“…However, because cataract patients may also suffer from other blinding eye diseases, ophthalmologists must diagnose them before surgery. …”
Get full text

ICD-10-AM codes for cirrhosis and related complications: key performance considerations for population and healthcare studies by Kelly L Hayward, Amy L Johnson, Benjamin J Mckillen, Vikas Bansal, Leigh U Horsfall, Gunter Hartel, Chris Moser, Elizabeth E Powell, Patricia C Valery

“…Objective The utility of International Classification of Diseases (ICD) codes relies on the accuracy of clinical reporting and administrative coding, which may be influenced by country-specific codes and coding rules. …”
Get full text

Dexmedetomidine induces immunogenic cancer cell death and sensitizes tumors to PD-1 blockade by Peng Liu, Guido Kroemer, Oliver Kepp, Jonathan Pol, Liwei Zhao, Lucillia Bezu, Allan Sauvat, Jiani Liu, Killian Carnet Le Provost, Andrea Checcoli

“…A machine learning-based algorithm trained with information on the biological effects and molecular descriptors of analgesics, anesthetics, hypnotics and opioids predicted antitumor effects for dexmedetomidine (DEX). …”
Get full text

Evaluation of multiple machine learning models predicting the results of hybrid imaging in primary hyperparathyroidism by Anna Drynda, Jacek Podlewski, Karolina Kucharczyk, Grzegorz Sokołowski, Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk, Małgorzata Trofimiuk- Müldner

“…Preoperative localization of the affected gland with imaging may increase the effectiveness of the surgical treatment. …”
Get full text

AI-enabled obstetric point-of-care ultrasound as an emerging technology in low- and middle-income countries: provider and health system perspectives by Sara Della Ripa, Nicole Santos, Dilys Walker

“…First, AI-enabled POCUS elicited concerns around algorithmic accuracy and compromised clinical acumen due to over-reliance on AI, but an interest in gestational age automation. …”
Get full text

Cortical Connectivity Response to Hyperventilation in Focal Epilepsy: A Stereo-EEG Study by Lorenzo Ferri, Federico Mason, Lidia Di Vito, Elena Pasini, Roberto Michelucci, Francesco Cardinale, Roberto Mai, Lara Alvisi, Luca Zanuttini, Matteo Martinoni, Francesca Bisulli

“…Our findings show that the cortical connectivity, estimated via the phase transfer entropy (PTE) algorithm, strongly increases during the HV maneuver, similar to non-REM sleep. …”
Get full text

Comprehensive Approach to Developing Baseline Reference Ranges for Platelet Function by Olga B. Gordeeva, Maria S. Karaseva, Vasily A. Lastovka, Nato D. Vashakmadze, Margarita A. Soloshenko, Gregory V. Revunenkov, Kirill A. Valyalov, Viktor V. Altunin

“…The results of further research may contribute in the development of the algorithm for controlling antiplatelet therapy in patients with contraindications or with genetically determined low sensitivity to thrombocyte aggregation inhibitors based on acetylsalicylic acid.…”
Get full text

Using Life’s Essential 8 and heavy metal exposure to determine infertility risk in American women: a machine learning prediction model based on the SHAP method by Xiaoqing Gu, Qianbing Li, Xiangfei Wang

“…Further analysis showed that there was a significant interaction between heavy metals and LE8, which may have a synergistic effect on the risk of female infertility.ConclusionsThis study used LE8 and heavy metal exposure to create a machine learning model that predicts the risk of female infertility. …”
Get full text

Nonlinear main components of the cytokine profile in children with community-acquired pneumonia by N. V. Iziurova, D. Yu. Nokhrin, A. Yu. Savochkina, A. N. Uzunova

“…The highest correlation with severity was shown for IFNλ2 (IL-28A), IFNλ3 (IL-28B) and MCP-1, which may be considered additional biomarkers of the CAP severity. …”
Get full text

Quality of a fished resource: Assessing spatial and temporal dynamics. by Sarah J Teck, Julio Lorda, Nick T Shears, Tal Ben-Horin, Rebecca E Toseland, Sarah T Rathbone, Dave Rudie, Steven D Gaines

Get full text

Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylases. by Mario A Inchiosa

Get full text

Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology by Shasha Wu, Shasha Wu, Qing Jiang, Jinhui Wang, Jinhui Wang, Daming Wu, Yan Ren

“…GSEA analysis suggested that these genes may be involved in biological processes such as protein export, RNA degradation, and fc gamma r mediated cytotoxis. …”
Get full text

WGCNA-ML-MR integration: uncovering immune-related genes in prostate cancer by Jing Lv, Jing Lv, Yuhua Zhou, Yuhua Zhou, Shengkai Jin, Shengkai Jin, Chaowei Fu, Chaowei Fu, Yang Shen, Yang Shen, Bo Liu, Bo Liu, Menglu Li, Yuwei Zhang, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…MR analysis demonstrated that MSMB may be an important protective factor for prostate cancer. …”
Get full text

Incremental predictive value of liver fat fraction based on spectral detector CT for major adverse cardiovascular events in T2DM patients with suspected coronary artery disease by Min Wang, Tanglin Wei, Li Sun, Yanhua Zhen, Ruobing Bai, Xiaomei Lu, Yue Ma, Yang Hou

“…How might this study influence clinical practice? Study findings may guide personalized prevention for T2DM patients at higher MACE risk.…”
Get full text

Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson's disease. by Jay S Schneider

Get full text

Phylogenetic diversity and antioxidant activities of culturable fungal endophytes associated with the mangrove species Rhizophora stylosa and R. mucronata in the South China Sea. by Jing Zhou, Xiaoping Diao, Tao Wang, Guangying Chen, Qiang Lin, Xiaobo Yang, Jing Xu

Get full text