Unveiling patient profiles associated with elevated Lp(a) through an unbiased clustering analysis by Miguel Saraiva, Jonatas Garcez, Beatriz Tavares da Silva, Inês Poças Ferreira, José Carlos Oliveira, Isabel Palma

“…Lp(a) levels were deliberately excluded from the algorithm, to ensure an unbiased cluster formation.ResultsThe analysis revealed two distinct clusters based on Lp(a) levels. …”
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Spatial multi-omics analysis of tumor-stroma boundary cell features for predicting breast cancer progression and therapy response by Yuanyuan Wu, Youyang Shi, Zhanyang Luo, Xiqiu Zhou, Yonghao Chen, Xiaoyun Song, Sheng Liu

“…However, the spatial transcriptional profile of the tumor boundary and its role in the prognosis and treatment response of breast cancer remain unclear.MethodUtilizing the Cottrazm algorithm, we reconstructed the intricate boundaries and identified differentially expressed genes (DEGs) associated with these regions. …”
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The relationship between immune cell infiltration and necroptosis gene expression in sepsis: an analysis using single-cell transcriptomic data by Shouyi Wang

“…These findings improve our understanding of sepsis mechanisms and may guide future therapeutic strategies targeting necroptosis pathways.…”
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Seasonal optimization of solar PV tilt angles for enhanced energy efficiency in Rajasthan, India by Saaransh Choudhary, Shiv Lal, Sumit Verma

“…For this purpose, a general algorithm for the optimization of the solar tilt angle is investigated based on MATLAB software for four different locations in Rajasthan, India. …”
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Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration by Bo Wu, Xinzhou Huang, Mu Zhang, Wei Chu

“…Our study of immune patterns may guide the strategies of prevention and treatment for IDD in the future.…”
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Analysis of Microbiome for AP and CRC Discrimination by Alessio Rotelli, Ali Salman, Leandro Di Gloria, Giulia Nannini, Elena Niccolai, Alessio Luschi, Amedeo Amedei, Ernesto Iadanza

“…Subsequently, the synthesised data quality was evaluated using a logistic regression model in parallel with an optimised support vector machine algorithm (polynomial kernel). The data quality is considered good when neither of the two algorithms can discriminate between real and synthetic data, showing low accuracy, F1 score, and precision values. …”
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MRI-based machine learning radiomics for prediction of HER2 expression status in breast invasive ductal carcinoma by Hong-Jian Luo, Jia-Liang Ren, Li mei Guo, Jin liang Niu, Xiao-Li Song

“…A simulated annealing algorithm was used for key feature selection. Two classification tasks were performed: task 1, the classification of HER2-positive vs. …”
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Analytical screening of polymorphic variants of 20S proteasome genes when planning a study of pathogenetic effects of modification of NFKB1 post-translational processing by A. V. Meyer, M. V. Ulyanova, D. O. Imekina, A. D. Padyukova, T. A. Tolochko, E. A. Astafieva, M. B. Lavryashina

“…To calculate the genetic distances between populations, we used the methord of comparing the populations by frequencies of polymorphic marker alleles proposed by Ney, the obtained matrices are illustrated by the method of multidimensional scaling in space using Statistica v.8.0.Results. Discussion of the algorithm and results of analytical screening of polymorphic variants of 14 genes (PSMA1-PSMA7, PSMB1–PSMB7) encoding proteasome subunits 20S. …”
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A Convolutional Neural Network Model for Classifying Resting Tremor Amplitude in Parkinson’s Disease by Augusto Ielo, Serena Dattola, Lilla Bonanno, Paolo De Pasquale, Alberto Cacciola, Angelo Quartarone, Maria Cristina De Cola

“…However, it relies on subjective evaluation which may introduce intra- and inter-individual biases in tremor assessment. …”
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Analysis of Drill String Whirling Characteristics Based on Near-Bit Measurement Data by Zhang Tao, Yang Zhenpeng, Li Jun, Wang Miaorui, Wang Mengfan, Guo Zixian

“…However， in the drilling process， affected by cutting of formation by bit and friction between drill string and wellface， forward whirling and backward whirling may occur alternately， and the forward whirling and backward whirling cannot be judged only by the period of vibration displacement signal. …”
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Vitamin C improves 28-day survival in patients with sepsis-associated acute kidney injury in the intensive care unit: a retrospective study by Yang He, Jinglan Liu

“…Consistency was maintained across PSM, paired algorithm, and overlap weighting analyses, with all p < 0.001.ConclusionVitamin C supplementation during ICU admission may be associated with reduced in-hospital mortality in SA-AKI patients. …”
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Image-based 3D active sample stabilization on the nanometer scale for optical microscopy by Jakob Vorlaufer, Nikolai Semenov, Caroline Kreuzinger, Manjunath G. Javoor, Bettina Zens, Nathalie Agudelo Dueñas, Mojtaba R. Tavakoli, Marek Šuplata, Wiebke Jahr, Julia Lyudchik, Andreas Wartak, Florian K.M. Schur, Johann G. Danzl

“…Although drifts in the lateral plane can often be corrected after acquisition, this is not always possible or may come with drawbacks. Therefore, it is appealing to stabilize sample position in three dimensions (3D) during acquisition. …”
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Artificial Intelligence in Pediatric Blood Transfusion during Anesthesia: A Scoping Review by Parisa Akbarpour, Parisa Moradimajd, Azam Saei, Maryam Aligholizadeh, Siavash Sangi

“…Methods: The study, conducted from early 2024 to May 2024, aimed to evaluate the effectiveness of artificial intelligence (AI) and machine learning (ML) in predicting blood transfusion needs and bleeding risks in pediatric anesthesia. …”
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Untargeted pixel-by-pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging by Huiyong Cheng, Dawson Miller, Nneka Southwell, Paola Porcari, Joshua L Fischer, Isobel Taylor, J Michael Salbaum, Claudia Kappen, Fenghua Hu, Cha Yang, Kayvan R Keshari, Steven S Gross, Marilena D'Aurelio, Qiuying Chen

“…Importantly, recognition of correlated metabolite pairs may contribute to the discovery of unanticipated molecules in shared metabolic pathways. …”
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FinSafeNet: securing digital transactions using optimized deep learning and multi-kernel PCA(MKPCA) with Nyström approximation by Ahmad Raza Khan, Shaik Shakeel Ahamad, Shailendra Mishra, Mohd Abdul Rahim Khan, Sunil Kumar Sharma, Abdullah AlEnizi, Osama Alfarraj, Majed Alowaidi, Manoj Kumar

“…These improvements further help the model to detect the relevant features in transaction data that may present a threat to the security of the system. …”
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Supraglacial Lake Depth Retrieval from ICESat-2 and Multispectral Imagery Datasets by Quan Zhou, Qi Liang, Wanxin Xiao, Teng Li, Lei Zheng, Xiao Cheng

“…With global warming, supraglacial lakes may become more extensive on ice sheet surfaces than they currently are. …”
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Systematic Construction and Validation of a Novel Ferroptosis-Related Gene Model for Predicting Prognosis in Cervical Cancer by Wentao Qin, Can He, Daqiong Jiang, Yang Gao, Yu Chen, Min Su, Yuanjun Yang, Zhao Yang, Hongbing Cai, Hua Wang

“…The least absolute shrinkage and selection operator (LASSO) algorithm and Cox regression analysis were conducted to develop a novel prognostic signature. …”
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Using AlphaFold-Multimer to study novel protein-protein interactions of predation essential hypothetical proteins in Bdellovibrio by Ibukun John Abulude, Isabel Cristina Rodríguez Luna, Alejandro Sánchez Varela, Andrew Camilli, Daniel E. Kadouri, Xianwu Guo

“…Our approach to characterize these proteins employing Alphafold has revealed novel interactions among attack phase-hypothetical proteins, which may be involved in less understood mechanisms of the Bdellovibrio attack phase. …”
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Prediction of Human Papillomavirus-Host Oncoprotein Interactions Using Deep Learning by Sheila Santa, Samuel Kojo Kwofie, Kwasi Agyenkwa-Mawuli, Osbourne Quaye, Charles A Brown, Emmanuel A Tagoe

“…Conclusion: The current model strongly predicted HPVs E6 and E7 interactions with PI3K pathway, and the viral proteins may be involved in AKT activation, driving HPV-associated cancers. …”
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An optimization method for hemi-diaphragm measurement of dynamic chest X-ray radiography during respiration based on graphics and diaphragm motion consistency criterion by Yingjian Yang, Jie Zheng, Peng Guo, Tianqi Wu, Qi Gao, Yong Li, Chengcheng Liu, Yang Liu, Yingwei Guo, Huai Chen

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