Ginkgetin Alleviates Inflammation and Senescence by Targeting STING by Yadan Liu, Jialin Ye, Zisheng Fan, Xiaolong Wu, Yinghui Zhang, Ruirui Yang, Bing Jiang, Yajie Wang, Min Wu, Jingyi Zhou, Jingyi Meng, Zhiming Ge, Guizhen Zhou, Yuan Zhu, Yichuan Xiao, Mingyue Zheng, Sulin Zhang

“…To reveal the molecular mechanism of Ginkgetin's anti‐aging effect, a graph convolutional network‐based drug “on‐target” pathway prediction algorithm for prediction is employed. The results indicate that the cGAS‐STING pathway may be a potential target for Ginkgetin. …”
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Tracking gain and loss of impervious surfaces by integrating continuous change detection and multitemporal classifications from 1985 to 2022 in Beijing by Xiao Zhang, Liangyun Liu, Wenhan Zhang, Linlin Guan, Ming Bai, Tingting Zhao, Zhehua Li, Xidong Chen

“…Afterwards, a novel optimization algorithm considering spatial heterogeneity and taking advantage of the LandTrendr algorithm was also proposed to optimize the spatiotemporal consistency of these impervious-surface maps. …”
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Machine Learning Creates a Simple Endoscopic Classification System that Improves Dysplasia Detection in Barrett’s Oesophagus amongst Non-expert Endoscopists by Vinay Sehgal, Avi Rosenfeld, David G. Graham, Gideon Lipman, Raf Bisschops, Krish Ragunath, Manuel Rodriguez-Justo, Marco Novelli, Matthew R. Banks, Rehan J. Haidry, Laurence B. Lovat

“…These generate a simple algorithm to accurately predict dysplasia. Once taught to non-experts, the algorithm significantly improves their rate of dysplasia detection. …”
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Comparison of four different assays to evaluate cellular-mediated immunity against cytomegalovirus in solid organ transplantation by Angela Casas-Parra, Angela Casas-Parra, Hendrik Veltman, Alba Romero-Caballero, Alba Romero-Caballero, Rosana Gelpi-Remiro, Rosana Gelpi-Remiro, Marc Boigues-Pons, Imán Allalou, Ian Linares-Pardo, Anna Vila-Santandreu, Anna Vila-Santandreu, Eva Martínez-Cáceres, Eva Martínez-Cáceres, Eva Martínez-Cáceres, María Iglesias-Escudero, María Iglesias-Escudero, María Iglesias-Escudero

“…This algorithm involves testing patients using the QuantiFERON-CMV® assay, followed by AIM testing in cases of indeterminate results or HLA mismatches. …”
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CatSkill: Artificial Intelligence-Based Metrics for the Assessment of Surgical Skill Level from Intraoperative Cataract Surgery Video Recordings by Binh Duong Giap, PhD, Dena Ballouz, MD, Karthik Srinivasan, MD, MS, Jefferson Lustre, BS, Keely Likosky, BS, Ossama Mahmoud, MD, Shahzad I. Mian, MD, Bradford L. Tannen, MD, JD, Nambi Nallasamy, MD

“…Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.…”
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Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism by Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li

“…We also hypothesized CYP 3A4 rs4646437 A>G, CYP 3A4 rs2246709 G>A, and CYP 2C19 rs12768009 A>G to be mutations that enhanced enzyme activity, while CYP1A2 rs762551 C>A weakened it.DiscussionThe pharmacokinetic changes of GP1707D07 during itraconazole co-administration are insufficient to warrant clinical action. Random forest algorithm enhances the understanding of pharmacogenetic variants involved in GP1707D07 metabolism and may serve as a potent tool for assessing gene polymorphism data in small clinical samples.Clinical Trial Registrationclinicaltrials.gov, identifier NCT05789342.…”
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A Three-Stage-Concatenated Non-Linear MMSE Interference Rejection Combining Aided MIMO-OFDM Receiver and its EXIT-Chart Analysis by Jue Chen, Siyao Lu, Tsang-Yi Wang, Jwo-Yuh Wu, Chih-Peng Li, Soon Xin Ng, Robert G. Maunder, Lajos Hanzo

“…Based on this concept, we then design a novel NL equalizer relying on the Smart Ordering and Candidate Adding (SOCA) algorithm. This reduced complexity NL detection algorithm is particularly well suited for practical hardware implementation using parallel processing at a low latency. …”
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Human motion capture data recovery based on non-convex low-rank priors of temporal difference(非凸时序差分低秩约束的人体运动捕获数据恢复算法) by 胡文玉(HU Wenyu), 彭绍婷(PENG Shaoting), 郭震宇(GUO Zhenyu), 黄慧英(HUANG Huiying)

“…However, as the frame number increases, the low-rank property may not be satisfied. To characterize the low-rank property of motion data well, a non-convex temporal difference low-rank constrained human motion capture data recovery algorithm is proposed by combining the Schatten-p norm and the q-norm. …”
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Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

“…This was confirmed by the XGboost algorithm, and decision curves confirmed the higher clinical net benefit of the combined model. …”
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Correlation Between Electronic Patient-Reported Outcomes and Biological Markers of Key Parameters in Acute Radiation Cystitis Among Patients With Prostate Cancer (RABBIO): Prospect... by Carole Helissey, Sophie Cavallero, Nathalie Guitard, Hélène Thery, Charles Parnot, Antoine Schernberg, Imen Aissa, Florent Raffin, Christine Le Coz, Stanislas Mondot, Christos Christopoulos, Karim Malek, Emmanuelle Malaurie, Pierre Blanchard, Cyrus Chargari, Sabine Francois

“…The results of this study may help to develop mitigation strategies to limit radiation damage to the bladder.…”
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A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers by Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller

“…These observations suggest that a molecular basis for effective immunity may exist within a subpopulation of HGSC. Herein, we developed an algorithm, CONSTRU (Computing Prognostic Marker Dependencies by Successive Testing of Gene-Stratified Subgroups), to facilitate the discovery and characterization of molecular backgrounds of HGSC that confer resistance or susceptibility to protective anti-tumor immunity. …”
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Hybrids versus parental species: insights from wing phenotype similarities and differences in triatomine insects by Álvaro Lara, María Laura Hernández, María Laura Hernández, César A. Yumiseva, Mario J. Grijalva, Mario J. Grijalva, Anita G. Villacís

“…Discriminant analysis was more effective for distinguishing parental groups than with hybrids. The K-means algorithm successfully classified the parental species and hybrid groups, although with low assignment percentages and a different number of groups than expected.DiscussionThe smaller wing size in hybrid offspring may indicate lower fitness, potentially due to genetic effects or reduced viability. …”
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Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…In such a context, data-driven approaches applied to pre-existing data may allow identifying patterns, correlations, and trends that may not be apparent through more restricted hypothesis-driven studies. …”
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CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity by Wangbing Hong, Xin Wang, Xinyu Huang, Pengfei Chen, Yifan Liu, Ziying Zheng, Xin You, Yinghua Chen, Zengxin Xie, Gongnan Zhan, Heping Huang

“…The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was then applied to refine the gene set and construct a 13-gene prognostic model. …”
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Power structure in Chilean news media. by Jorge Bahamonde, Johan Bollen, Erick Elejalde, Leo Ferres, Barbara Poblete

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Identification and validation of endoplasmic reticulum autophagy-related potential biomarkers in periodontitis by Ruyue Wang, Jinyue Hu, Qing Sun, Shuixiang Guo, Gege Zhang, Ao Lu, Shuo Liu, Xue Yang, Lina Wang

“…The CIBERSORT deconvolution algorithm was used to study the link between potential biomarkers and distinct types of immune cells. …”
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Prediction of Clinical Bronchiectasis from Asymptomatic Radiological Bronchiectasis by Fan Y, Li Z, Jiang N, Zhou Y, Song J, Yu F, Zhang J, Wang X

“…Whether the ARB could progress to CB and the risk factors to speed up the process are poorly understood.Methods: This was an observational cohort study. 370 patients with radiological bronchiectasis were included in Wuhan Union Hospital in 2018. 296 ARB patients were followed up in 2022 to verify if they progressed to CB and divided the development and validation of clinical prediction models into a training set (n=207) and a validation set (n=89) by the ratio of 7:3. LASSO algorithm and multivariable logistic regression analysis were performed to construct a new nomogram model. …”
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Photometric and Spectroscopic Analysis of Eight Totally Eclipsing Contact Binaries with Small Mass Ratios by Li-Heng Wang, Kai Li, Ya-Ni Guo, Jing-Yi Wang, Xiang Gao, Xing Gao, Guo-You Sun

“…Four of them display a long-term decreasing trend in orbital period, while the other three show a long-term increasing trend, and two targets exhibit periodic variations. A decrease in period may be caused by the transfer of matter from the more massive component to the less massive component, while an increase in period may be caused by transfer in the opposite way. …”
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Phasic and periodic change of drought under greenhouse effect by Yang Li, Zhicheng Zheng, Yaochen Qin, Haifeng Tian, Zhixiang Xie, Peijun Rong

“…Subsequently, the Bernaola-Galvan segmentation algorithm was proposed to divide the periods of drought change and the newly developed extreme-point symmetric mode decomposition to analyze the periodic drought patterns. …”
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Nutrient Availability and Pathogen Clearance Impact Microbiome Composition in a Gnotobiotic Kimchi Model by Devin H. Bemis, Carly E. Camphausen, Esther Liu, Joshua J. Dantus, Josue A. Navarro, Kieren Leif Dykstra, Leila A. Paltrowitz, Mariia Dzhelmach, Markus Joerg, Pamil Tamelessio, Peter Belenky

“…Together, these findings suggest that monitoring total microbial composition, and not just the presence of pathogens, may be important for ensuring kimchi fermentation reproducibility.…”
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