Changes in the concentration of freely circulating mutant DNA and wild-type DNA of the H3F3А (K27M) gene in the blood and cerebrospinal fluid of children with diffuse midline gliom... by O. S. Regentova, V. K. Bozhenko, E. A. Kudinova, T. M. Kulinich, E. L. Dzhikiya, V. V. Kaminskiy, F. F. Antonenko, R. A. Parkhomenko, N. I. Zelinskaya, N. Sidibe, P. V. Polushkin, A. I. Shevtsov, M. A. Bliznichenko, V. A. Solodkiy

“…To study the possibility of detecting freely circulating DNA of the H3F3A (K27M) gene in blood plasma and cerebrospinal fluid in the lumbar spine in children with diffuse midline gliomas (DMG) during a course of radiation therapy (RT).Materials and methods. Molecular genetic studies were carried out by digital PCR. 96 samples of lumbar cerebrospinal fluid and 288 samples of peripheral blood plasma from 96 pediatric patients were analyzed. …”
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Comparative Evaluation of Oral Melatonin versus Oral Alprazolam as Premedication in Patients Undergoing Tympanoplasty: A Randomised Control Study by Nupoor, Shikha Agarwal, Harsh Vardhan, Nikhil Nayar

“…Aim: To compare the effects of oral melatonin versus oral alprazolam as premedication and their impact on postoperative recovery characteristics in patients undergoing tympanoplasty. Materials and Methods: In this randomised controlled study which was conducted from August 2022 to March 2024 at the Department of Anaesthesiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India, a total of 70 adult patients were randomly allocated into two groups. …”
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Prognostic values of the diastolic index as a marker of chronic heart failure with preserved left ventricular ejection fraction by V. V. Syvolap, V. A. Lysenko

“…To prove the diagnostic and prognostic value of the diastolic index as an additional criterion for the HFpEF phenotyping in the European population. Materials and methods. The study enrolled 88 patients (men – 46.6 % (n = 41); women – 53.4 % (n = 47)) with CHF of ischemic origin, stage II A–B, NYHA class II–IV. …”
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Exclusive breastfeeding until six months of age and its influence on anthropometric indices: A prospective observational study by Asha Jyothi Penugonda, Magdalenal Robert, George Ipe Vettiyil, Balamurugan Durai, Rajeev Zachariah Kompithra, Lakshmanan Jeyaseelan, Leni Grace Mathew

“…Aims and Objectives: We conducted a prospective study to assess the prevalence of EBF and the extent of influence of modifiable and nonmodifiable variables on anthropometric indices among infants from birth to 6 months of age. Materials and Methods: Healthy term infants born in a tertiary care hospital in South India were recruited at birth. …”
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DIFFERENT RESPONSE OF HUMAN BLOOD NEUTROPHIL FCᵧRIIIB (CD16) TO EX VIVO MODELING OF BACTEREMIA BY PATHOGENIC AND OPPORTUNISTIC MICROORGANISMS by Alexander Leonidovich Kravtsov, Svetlana Nikolaevna Klyueva, Tatyana Petrovna Shmelkova, Vitaly Alexandrovich Kozhevnikov, Svetlana Aleksandrovna Bugorkova

“…The purpose of the work was to compare the ex vivo reaction of human neutrophil FcᵧRIIIb in response to the addition in blood the live cells of  opportunistic (Escherichia coli, Staphylococcus aureus) and pathogenic (Yersinia pestis, Brucella abortus) bacterial species. Materials and methods. The density of CD16 expression on NG was determined by flow cytometry in arbitrary fluorescence intensity units (MFI) after staining leukocytes with CD45-FITC and CD16-PE reagents (Backman Coulter, USA) when immunophenotyping them in the blood according to the Lyse/No-Wash protocol. …”
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BIOMECHANICAL STUDY OF SINGLE ROOTED TEETH RESTORED WITH DOWEL CORS by M. M. Klepach, B.Y. Silenko, T. A. Khmil, M. V. Khrebor, Y. I. Silenko

“… The purpose of the biomechanical study was a comparative analysis of the stress-strain state of the dowel core, dentin of the tooth root, periodontal and bone tissues of the alveolus in the restoration of the first premolars using dowel core, made of zirconium oxide. Materials and methods. Mathematical modeling was carried out using a service modeling and finite element analysis NASTRAN, designed for implementation on a personal computer in a Windows environment. …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…The aim of this study was to investigate whether soluble programmed cell death-ligand 1 (sPD-L1) could be a predictive biomarker in patients with epidermal growth factor receptor (EGFR)-positive NSCLC. Materials and Methods: Blood samples from 35 patients with EGFR-mutated (EGFRmut) adenocarcinoma who achieved disease control with EGFR tyrosine kinase inhibitor (EGFR TKI) therapy were collected for sPD-L1 analysis. …”
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The effectiveness of e-learning in focused cardiac ultrasound training: a prospective controlled study by Johannes Ruppert, Rebecca Krüger, Sebastian Göbel, Susanna Wolfhard, Liv-Annebritt Lorenz, Andreas Michael Weimer, Roman Kloeckner, Elias Waezsada, Holger Buggenhagen, Julia Weinmann-Menke, Johannes Matthias Weimer

“…This study investigates the effectiveness of e-learning in imparting FOCUS skills. Materials and methods This prospective, controlled study assessed competency development among medical students attending a FOCUS workshop (study group) at two time points: T1 (pre-training) and T2 (post-training, after completing e-learning). …”
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Evaluation of the Efficiency of a Soft Dosage Form for the Treatment of Osteoarthritis: Influence on the Level of Pro-inflammatory Cytokines by U. V. Nogaeva, V. E. Kovanskov, D. Yu. Ivkin, E. V. Flisyuk, K. D. Yakimov, E. I. Yeletskaya, E. D. Semivelichenko, V. G. Antonov

“…Evaluation of the effect of a previously developed soft dosage form containing meloxicam, a purine derivative and an immunomodulator M on the level of pro-inflammatory cytokines: IL-1α, IL-1β, IL-6 and TNF-α in osteoarthritis.Materials and methods. The experiment included 25 animals, which were divided into 5 groups by simple randomization: 1 – test (gel 0.5 %), 2 –test (gel 1 %), 3 – reference (Amelotex®, gel 1 %), 4 – control (gel base); 5 – intact. …”
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Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation by Beshish Asaad G., Aljiffry Alaa, Xiang Yijin, Evans Sean, Scheel Amy, Harriott Ashley, Patel Shayli, Amedi Alan, Harding Amanda, Davis Joel, Shashidharan Subhadra, Kwiatkowski David M.

“…Background: Patients requiring extracorporeal life support (ECLS) support post-Norwood operation constitute an extremely high-risk group. Materials and methods: We retrospectively aimed to evaluate the relationship of hyperoxia with mortality and other clinical outcomes in patients who required ECLS following Norwood operation between January/2010 and December/2020 in a large volume center. …”
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Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a–5 Chronic Kidney Disease by Francisco Mendoza Carrera, Gloria Elizabeth Vázquez Rivera, Caridad A. Leal Cortés, Lourdes del Carmen Rizo De la Torre, Renato Parra Michel, Rosalba Orozco Sandoval, Mariana Pérez Coria

“…The aim of this study was to evaluate the relationship between UA levels and mineral bone metabolism and inflammation biomarkers in a sample of Mexican patients with CKD 3a–5. <i>Materials and Methods</i>: This cross-sectional study included 146 Mexican patients with CKD 3a–5. …”
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Prediction of Mortality in ICU Patients with SARS-CoV-2-Associated Pneumonia by P. N. Savilov, S. S. Kurdyumova, S. V. Shutova, S. V. Buchneva, A. V. Baranov

“…Aim: to determine the predictive value of selected routine clinical and laboratory parameters and to assess their prognostic significance for modeling mortality risk in intensive care unit (ICU) patients with SARS-CoV-2-associated pneumonia.Materials and Methods. A retrospective case-control analysis of 73 medical records was performed. …”
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The influence of MK-801, glutamate and glycine via the modulation of N-methyl-D-aspartate receptors on isolated rat heart by N. S. Govorushkina, S. B. Bolevich, V. Jakovlevich, B. I. Tachieva, S. S. Bolevich, A. S. Orlova, M. A. Fokina, A. B. Saltykov, E. M. Morozova, N. V. Samburova, M. N. Vukolova, E. B. Tezikov

“…To evaluate the influence of a non-competitive antagonist of NMDA-receptors — МК-801, separately or in combination with glutamate and/or glycine, on cardiodynamic parameters, coronary flow and oxidative stress biomarkers in isolated rat heart.Materials and methods. 40 Wistar albino rats were divided into 4 groups (10 rats per group). …”
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Is the both column fixation corridor a universally valid and consistent fixation pathway in pelvic and acetabular surgery? by Vedat Öztürk, Malik Çelik, Murat Tıngır, Furkan Özönder, Cemal Kural, Mustafa Gökhan Bilgili

“…This study aims to validate the BCFC as a consistent fixation pathway across genders, evaluate its axial fluoroscopic visualization, and investigate gender-specific anatomical variations for surgical planning. Materials and methods In this study, pelvic CT data from 400 adults (200 males, 200 females) were analyzed using Fujifilm-Synapse 3D software. …”
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Comparative immunohistochemical characteristics of expression of estrogen receptors-alpha, progesterone receptors, p16, p53, Ki-67 and caspase 3 in invasive endometrial adenocarcin... by V. A. Tumanskiy, A. V. Chepets

“…To characterize the expression of the estrogen receptors-alpha, progesterone receptors, p53, p16, ki-67 and caspase 3 in the invasive endometrioid endometrial adenocarcinoma compared with the normal proliferative endometrium. Materials and methods. The uteruses of 56 women with the verified diagnosis of endometrial cancer (stage pT1-4MxNx) and biopsies of 30 women with normal proliferetive endometrium were analyzed. …”
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Epidemiology of Vancomycin-Resistant Enterococci in Various Medical Wards by A. V. Liubimova, N. A. Shalyapina, V. V. Kolodzhieva, S. A. Riachovskich, O. V. Dmitrieva, T. V. Brodina, A. A. Shishmakov

“…The aim of this study was to define hospital units with high risk of VRE dissemination in health care facilities of St. Petersburg. Materials and Methods. Point-prevalence study of colonisation and infection in patients and contamination of the environment was conducted during 2013 - 2014 in 8 hospital units of different types: neonatal intensive care, newborn pathology, general paediatric surgery, bone marrow transplantation (BMT for adolescents), cancer surgery of the gastrointestinal (GI) tract and breast cancer, haemodialysis (three units). …”
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Comparison of medical history documentation efficiency and quality based on GPT-4o: a study on the comparison between residents and artificial intelligence by Xiaojing Lu, Xinqi Gao, Xinyi Wang, Zhenye Gong, Jie Cheng, Weiguo Hu, Shaun Wu, Rong Wang, Xiaoyang Li

“…This study aims to evaluate the efficiency and quality of medical history documentation by ChatGPT-4o compared to resident physicians and explore the potential applications of AI in clinical documentation.MethodsUsing a non-inferiority design, this study compared the documentation time and quality scores between 5 resident physicians from the hematology department (with an average of 2.4 years of clinical experience) and ChatGPT-4o based on identical case materials. …”
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Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021 by I. I. Dedov, M. V. Shestakova, O. K. Vikulova, A. V. Zheleznyakova, M. А. Isakov

“…The aim of our study was to analyze a dynamic (2016–2020) of the epidemiological characteristics of diabetes mellitus in the Russian Federation (prevalence, morbidity, mortality), the prevalence of complications, the level of HbA1c and the dynamics of the structure of glucose-lowering therapy (GLT) according to the Federal Diabetes Register (FDR).MATERIALS AND METHODs. The database of FRD (http://diaregistry.ru) 84 regions of the RF. …”
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Exploring oral hygiene practices, nutritional habits and caries risk among children, adolescents and young adults: a multiregional perspective in the post-COVID-19 era by Azhar Iqbal, Osama Khattak, Yasir Dilshad Siddiqui, Saud Hamdan Almaeen, Saeed Alqahtani, Saleh Ali Alqahtani, Saeed Awod Bin Hassan, Faisal Hasan Alshehri, Ali Y. Alsaeed, Mahmoud K. AL-Omiri

“…Aim The purpose of this research is to explore the impact of the COVID-19 pandemic on dietary behaviors, daily oral hygiene practices and caries risk among children, adolescents, and young adults from diverse regions within Saudi Arabia. Materials and methods A cross-sectional analytical study spanning multiple regions of Saudi Arabia was carried out to assess the effects of COVID-19 on dietary habits, oral hygiene practices, and caries risk across various age groups within the Saudi population. …”
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Evaluation of Problem Based Gamification Learning (PBGL) Model on Critical Thinking Ability with Artificial Intelligence Approach Integrated with ChatGPT API: An Experimental Study by Remerta Noni Naatonis, Rusijono Rusijono, Miftakhul Jannah, Edwin Ariesto Umbu Malahina

“…The main problems faced are the limited time of the lecturer in delivering the material, the lack of reference material, and the low motivation of students. …”
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