The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma by V. N. Pavlov, I. R. Gilyazova, A. A. Izmailov, E. A. Klimentova, I. R. Sultanov, M. A. Bermishev, Z. R. Akhmadeev, A. Kh. Nurgalieva, G. V. Ishbulatova, E. K. Khusnutdinova

“…However, further studies of the genes are needed to establish their functional significance and role in the pathogenesis of ccRCC.…”
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Linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQL^™ questionnaire for pediatric patient... by Anna L. Arakelyan, Andrey N. Surkov, Aleksander A. Baranov, Leyla S. Namazova-Baranova, Valeri V. Gorev, Elena B. Moskvina, Tamara A. Skvorcova, Artem V. Nikitin, Vladislav V. Chernikov

“…Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. Questionnaires that help assess the HRQL can give a concept of child’s state, identify arcane issues and they are of great importance for a full understanding of how the state of health affects the child. …”
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Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and survival in patients with systemic sclerosis by Gabriela Riemekasten, Felix Nensa, Hanna Grasshoff, René Hosch, Malte Maria Sieren, Lennart Berkel, Jörg Barkhausen, Roman Kloeckner, Franz Wegner

“…These parameters were analysed with regard to various clinical, laboratory, functional parameters and survival. Phenotypes were identified performing K-means cluster analysis. …”
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Characteristics of patients with chronic heart failure with mildly reduced ejection fraction: clinical and demographic aspect by M. T. Duishenalieva, A. G. Polupanov, F. T. Rysmatova, E. Zh. Myrzabekova, N. E. Esenbekova, N. Ch. Cholponbekova, E. Sh. Altymyshova, A. T. Arykova, N. B. Cheskidova, E. D. Djyshambaev

“…Type 2 diabetes mellitus was present in approximately one in five patients, regardless of the CHF phenotype. Patients with functional class III (NYHA) predominated among those with HFmrEF (54,5 %) and HFrEF (56,3 %).Conclusion. …”
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M.S. Myroshnychenko, Yu.М. Mishyn, М.М. Mishyna, І.А. Маrchеnkо, А.М. Burov by M.S. Myroshnychenko, Yu.М. Mishyn, М.М. Mishyna, І.А. Маrchеnkо, А.М. Burov

“…An important role in homeostasis and progression of kidney diseases is played by cytokines, which perform a number of biological functions and interact with other cells and tissues of the body. …”
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ANALYSIS OF POLYMORPHISM OF THE GENES OF THE PHASE II OF XENOBIOTICS BIOTRANSFORMATION (GSTM1, GSTT1) IN THE SHORIANS AND ALIEN POPULATION OF THE KEMEROVO REGION: THE PROBLEM OF TH... by Фаина Анисимовна Лузина, Анастасия Викторовна Дорошилова, Владимир Юрьевич Смирнов, Анастасия Сергеевна Казицкая, Ольга Николаевна Гуляева, Татьяна Константиновна Ядыкина, Анатолий Владимирович Колбаско

“…The indigenous Shorians are dominated by the frequencies of the non-mutant variants of the genes of xenobiotics biotransformation: GSTM1 (+) is 0.768, GSTT1 (+) is 0.743; the frequency of «null» functionally weakened genotypes and their combinations compared with the Europeoid population is reduced. …”
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Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women by N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya

“…The ADAMTS-13/vWF ratio determines the pathway functioning, the risk of microcirculation disorders and clinical complications.…”
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Environmental enrichment affects immunity and reduces disease severity in pigs after co-infection, with stronger effects when applied from birth than from weaning by Brigitte G. C. de Bruijn, Ingrid Danielle Ellen van Dixhoorn, J. Elizabeth Bolhuis, Jan B. W. J. Cornelissen, Norbert Stockhofe-Zurwieden, Marion Kluivers, Johanna M. J. Rebel, Johanna M. J. Rebel

“…We investigated whether environmental enrichment applied at different life stages of pigs affects the susceptibility to and severity of disease by studying immune cell functions around weaning and during nursery, the effects of infection in ex vivo models and in vivo using a co-infection model of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) followed by an Actinobacillus pleuropneumoniae infection. …”
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Multifunctional physical simulation test system for deep coal rockburst development and its application by Shoujian PENG, Qingfeng XU, Jiang XU, Liang CHENG, Bin ZHOU, Yan YANG, Feng JIAO

“…In order to conduct an in-depth research on the disaster causing laws of coal-rock burst and rock burst in deep strata, a multi-functional physical simulation test system for rock burst in deep strata has been independently developed. …”
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GABRP Mediates GABA‐A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy by Wu Cen, Genyuan Fu, Xiaoyu Wang, Ruting Wei, Xingwang Zhou, Wei Teng, Yuanguo Ling, Jiaze Tang, Zhongan Wang, Liangzhao Chu

“…Functional studies included GABRP knockdown in glioma cells (U87/U251) via lentiviral RNAi, proliferation/migration assays (CCK‐8, scratch test), and pathway analysis. …”
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Nanobiosensors for revolutionizing parasitic infections diagnosis: a critical review to improve global health with an update on future challenges prospect by Soheil Sadr, Ashkan Hajjafari, Alireza Sazmand, Cinzia Santucciu, Giovanna Masala, Mahdi Soroushianfar, Shakiba Nazemian, Abbas Rahdar, Sadanand Pandey, Moez Guettari, Hassan Borji

“…Nanobiosensors can utilize diverse nanomaterials such as gold nanoparticles (AuNPs) for the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) in Plasmodium, carbon nanotubes (CNTs) functionalized with anti-EgAgB antibodies for Echinococcus, and QDs labeled with DNA probes for the detection of Leishmania kDNA. …”
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PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation by Zicong Huang, Runduan Yi, Xixian Cen, Hanbin Zhang, Minyu Xie, Ke Ma, Shipeng Ruan, Yuge Zhuang, Xiaoyuan Zhang, Wenyuan Liu, Hongrui Feng, Deyu Chen, Mohamed Morsi M. Ahmed, Hong Liu, Chuyu Huang, Xiangjin Kang, Zhenguo Chen

“…Abstract Centriolar satellites facilitate the delivery of proteins required for centrosome assembly and function, and rely on the nucleation of the scaffold protein pericentriolar material 1 (PCM1). …”
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Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane by Maheen Rashid, Shoichi Tachiyama, Shiwei Zhu, Hang Zhao, William D. McCaig, Jingchuan Sun, Huilin Li, Jun Liu, David G. Thanassi

“…These findings reveal the cellular transformations that occur during membrane tubulation by Francisella and provide insights into the function of membrane-derived structures during host-pathogen interactions.IMPORTANCEFrancisella tularensis is an intracellular bacterial pathogen that causes the zoonotic disease tularemia. …”
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Evaluating the potential of graphene oxide to promote skeletal muscle complex regeneration by Yulu Chen, Zeyu Zhu, Yian Shen, Xuling Liu, Yushi He, Chengqi Lyu, Jiayu Lu

“…BackgroundRepair and regeneration of the musculoskeletal system are critical for maintaining mobility, physical function, and overall quality of life. This study aimed to optimize the size and concentration of graphene oxide (GO) to achieve a balance that enhances the proliferation and myogenic differentiation of C2C12 cells and investigate the underlying mechanisms, including the activation of key myogenic genes and signaling pathways. …”
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Comparison of Prolonged Transversus Abdominis Blockade with Systemic Anesthesia During Local Access to Double-Barreled Intestinal Stoma Closure (Preliminary Results of a Prospectiv... by I. A. Ermakov, V. V. Valetova, A. V. Savushkin, I. E. Gridchik, I. V. Molchanov, A. I. Moskalev, D. O. Kiselev

“…Over the course of 4 days, we assessed the daily dosage of tramadol and ketoprofen, the level of dynamic and static pain on a digital rating scale, the time and degree of activity, the frequency of urinary retention, the occurrence of nausea and vomiting, the timing of return to good nutrition and restoration of bowel function, and the duration of postoperative treatment.   …”
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THE ROLE OF TRANSFORMING GROWTH FACTOR BETA-1 AND GALECTIN-3 IN FORMATION OF THE LEFT ATRIUM FIBROSIS IN PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION AND METABOLIC SYNDROME by E. L. Zaslavskaya, A. N. Morozov, V. A. Ionin, I. Ma, S. Е. Nifontov, Е. I. Baranova, S. M. Yashin, E. V. Shlyakhto

“…To evaluate the prominence of fibrosis of the left atrium myocardium and to define the value of transforming growth factor beta 1 (TGF-beta1) and galectin-3 in development of myocardial fibrosis in atrial fibrillation (AF) patients with metabolic syndrome (MS).Material and methods. Totally, 58 patients with AF included, of those 27 with MS. …”
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Observation of Thickness-Modulated Out-of-Plane Spin–Orbit Torque in Polycrystalline Few-Layer Td-WTe₂ Film by Mingkun Zheng, Wancheng Zhang, You Lv, Yong Liu, Rui Xiong, Zhenhua Zhang, Zhihong Lu

“…Additionally, a detailed examination of magnetotransport properties in polycrystalline few-layer Td-WTe₂ films as a function of thickness revealed a marked amplification of the out-of-plane magnetoresistance, which can be ascribed to the anisotropic nature of charge carrier scattering mechanisms within the material. …”
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SAFETY OF MIXED ARTIFICIAL NUTRITION IN PATIENTS WITH SEVERE MULTISYSTEM CRANIOCEREBRAL TRAUM by A. P. Shakotko, Z. G. Marutyan, A. Y. Kinishemova, E. V. Klychnikova, E. V. Tazina, A. A. Ryk

“…However, it must be taken into account that in addition to positive effects, PN may be followed by a number of complications: hyperglycemia, hypertriglyceridemia, impaired pulmonary function, increased thrombogenesis..PURPOSE OF THE STUDY. …”
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CELL THERAPY OF EPILEPSIA. CLINICAL AND IMMUNOLOGICAL ASPECTS by T. V. Dokukina, M. P. Potapnev, S. M. Kosmacheva, F. P. Hlebokazov, E. L. Slobina, T. S. Golubeva, N. N. Misjuk, M. V. Mahrov, I. V. Shamruk, P. P. Korolevich, A. I. Martynenko, I. V. Bychenko, T. O. Bud’ko

“…The aim is to develop and implement a method for the treatment of drug-resistant epilepsy using autologous mesenchymal stem cells and the neuroimaging, immunological and neurophysiological predictors of the brain function.Material and Methods. Twenty patients (12 males and 8 females) with symptomatic drug-resistant epilepsy participated in the study. …”
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Re‐evaluating fetal scalp pH thresholds: An examination of fetal pH variations during labor by Aude Girault, Camille Le Ray, Charles Garabedian, François Goffinet, Xavier Tannier

“…The rate of change in pH value between consecutive samples for each patient was calculated and plotted as a function of pH value. Linear regression models were used to model the evolution of the pH drop rate estimating slope and standard errors across predefined pH intervals. …”
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