Genetic diversity and GWAS analysis of flesh hardness trait in Xinjiang melon germplasm resources by ZHU Wanting, LI Jiangfeng, ZHAN Qianru, SHUA Zhenyang, ZHU Yingchun, GUO Yanxia, LUO Xiang

“…The 98.05% of local varieties carried the hap001 haplotype. Hap004 haplotype materials exhibited soft and brittle characteristics, while hard materials carried hap001, hap002 and hap003 haplotypes. …”
Get full text

Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…These effects substantially enhance motor function in SCI rats, positioning it as a promising candidate for future clinical applications. …”
Get full text

Intermittent hypoxic preconditioning reduces the risk of peri- and postoperative complications during on-pump cardiac surgery by I. Dhif, O. S. Glazachev, Af. A. Bestavashvili, Ch. Sinlyan, E. P. Gulyaeva­Seltsovskaya, N. O. Kuznetsova, E. A. Syrkina, V. V. Smirnova, E. N. Dudnik, P. Sh. Chomakhidze, B. M. Tlisov, R. N. Komarov, F. Yu. Kopylov

“…To assess the effect of intermittent hypoxic-hyperoxic exposures (IHHE) on the outcomes of on-pump cardiac surgery.Material and methods. This prospective, single-center, randomized, controlled study was conducted in 110 patients with heart valve defects and/or aortic pathology from the cardiac surgery clinic of the I. …”
Get full text

Simulation of Pseudostellaria heterophylla distribution in China: assessing habitat suitability and bioactive component abundance under future climate change scenariosplant compone... by Xu Li, Taosheng Wu, Chuangzhi Kang, Xiaobo Zhang, Jinqiang Zhang, Changgui Yang, Qingsong Yuan, Tao Zhou, Chenghong Xiao

“…BackgroundPseudostellaria heterophylla is used in traditional Chinese medicine, so ensuring an adequate supply of plant material with high levels of bioactive components is important.MethodsUsing an optimized maximum entropy niche model and assays of bioactive components from cultivation samples, this study started from the plant’s natural distribution area and estimated correlations of ecological factors with not only abundance of the plant but also abundance of polysaccharides and heterophyllin B. …”
Get full text

Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes by Charlie R. Faulks, Dean T. Biddau, Michael D. Selby, Ralph J. Mobbs, Gregory M. Malham

“…Objectives: Graft material can impact fusion rates in anterior lumbar interbody fusion (ALIF) procedures. …”
Get full text

A METHOD FOR RESTORING ORAL CAVITY AND TONGUE USING A COMPOSITE, FREE, CHIMERIC, REVASCULARIZED, REINNERVED, MUSCULOCUTANEOUS FLAP AFTER TOTAL GLOSSECTOMY by A. P. Polyakov, A. D. Kaprin, M. V. Ratushnyy, O. V. Matorin, I. V. Rebrikova, M. M. Filyushin, A. V. Mordovskiy, P. A. Nikiforovich

“…These surgeries are inevitably associated with extensive defects in the oral cavity and tongue and, therefore, the loss of necessary organism functions. Currently, there is no optimal autotransplant for tongue reconstruction after total or subtotal removal of the tongue and oral floor muscles; it appears to be one of the most significant challenges in modern reconstructive surgery.Materials and methods. …”
Get full text

POSTCHOLECYSTECTOMY SYNDROME CAUSED BY VARIOUS DISORDERS OF INTESTINAL PERMEABILITY by Y. P. SAVCHENKO, V. M. BENSMAN, I. V. SUZDAL'CEV, G. K. KARIPIDI, V. A. GOLBRAIH, B. M. BELIK, N. J. KALININA, M. I. DENISOVA

“…Colostasis can cause functional changes in the biliary tract due to the overstretch of the colon areas by the accumulated contents.  …”
Get full text

Nanoengineered-based delivery systems to modulate CD4+ T cell responses in cancer: emerging paradigms in cancer immunotherapy by Nekhat Shahreen, Anukrati Agnihotri, Asfi Rizwan, Faizul Hasan, Mohd Danish Ansari, Zarif Mohamed Sofian, Nur Akmarina B. M. Said, Kenneth K. W. To, Syed Mahmood, Syed Mahmood, Syed Mahmood, Syed Mahmood

Get full text

Rivaroxaban versus low-molecular-weight heparins for short- and long-term prognosis in patients with deep vein thrombosis after spontaneous intracranial hemorrhage by Jingfan Li, Qi Song, Guannan Tong, Chengyu Bian, Huimei Zhang, Hulin Zheng, Yafei Wang

“…Multivariate and inverse probability of treatment weighting-adjusted analyses confirmed the association of rivaroxaban with reduced 1-year mortality and better functional recovery. Conclusion: Rivaroxaban use in DVT patients after sICH was associated with lower long-term mortality and better functional independence, without significantly increasing the risk of sICH recurrence or bleeding complications. …”

Comparative evaluation of caudal epidural, interlaminar, and transforaminal epidural steroid injection in patients with lumbar spinal canal stenosis by Jyotsna, Amit Kumar, Anshul, Naveen Malhotra, Navya Malhotra, Ritwik Gupta

“…TFESI is better than other two techniques in terms of improvement in pain score, treatment outcome, and functional disability.…”
Get full text

ACTUAL PROBLEMS OF PROFESSIONAL AND PERSONAL DEVELOPMENT QUALIFIED PERSONS RESPONSIBLE FOR QUALITY OF MEDICINAL PRODUCTS FOR HUMAN USE by Zh. I. Aladysheva, N. V. Pyatigorskaya, V. V. Belyaev, N. S. Nikolenko, E. I. Nesterkina, S. A. Loseva

“…Most of them had a working experience in 1–2 divisions of the enterprise, and combined the functions of qualified persons with managerial positions (74.5% and 71.9%, respectively). …”
Get full text

First-Principles Study of Mechanical Properties of Pb(Zr_xTi_1−x)O₃ in the Cubic and Tetragonal Phase by Xudong Ran, Shaolan Zhou, Shaowen Zhou, Wei Lei, Lin Xiang, Yang Wu, Bingfei Hu, Jianquan Tao, Qiang Chen

“…In this study, we employed the first-principles method based on density functional theory to calculate the elastic constants, bulk modulus, shear modulus, Young’s modulus, Poisson’s ratio, and density of states for both cubic and tetragonal phases of Pb(Zr_xTi_1−x)O₃. …”
Get full text

Determination of a willingness-to-pay threshold and decision-making in financing the healthcare technologies by T. S. Teptsova, T. P. Bezdenezhnyh, V. K. Fedyaeva, N. Z Musina, G. R. Hachatryan, V. V. Tarasov

“…The aim was to develop a methodology for determining the willingness to pay threshold (WTPT) and its upper limit value within the Russian health care system.Materials and methods. WTPT was calculated based on the shadow budget price (i. e. determining the WTPT by the suppling party). …”
Get full text

Features of the cytokine profile in the structures of chorion and placenta in premature termination of pregnancy by A. A. Zhyvetska-Denysova, I. I. Vorobiova, N. Ya. Skrypchenko, V. B. Tkachenko

“…Inflammation plays a leading role in the development of preterm birth. Structural and functional changes in the placenta against the background of inflammation make up the morphological substrate of chronic placental dysfunction, which, in a case of decompensation, triggers the process of preterm birth. …”
Get full text

Minilaparoscopic Versus Conventional Laparoscopic Hysterectomy: Insights from a Single-Center Retrospective Cohort Study with Legal Considerations by Valentina Billone, Giuseppe Gullo, Eleonora Conti, Silvia Ganduscio, Sofia Burgio, Giovanni Baglio, Gaspare Cucinella, Lina De Paola, Susanna Marinelli

“…<i>Conclusions</i>: This retrospective study demonstrated that MLH is an effective and functional technique for treating various gynecological conditions, with advantages in terms of aesthetic outcomes and reduced perioperative pain and recovery times. …”
Get full text

METABOLISM FEATURES IN HIGHLY TRAINED HOCKEY-PLAYERS DURING CONTEST SEASON by S. A. KOLESOV, R. S. RAKHMANOV, T. V. BLINOVA, L. A. STRAKHOVA, R. Sh. KHAYROV

“…To evaluate the dynamics of metabolic status features in highly trained hockey-players during contest season.Materials and methods. 33 highly trained hockey-players were examined. …”
Get full text

SPL-108 mitigates metastasis and chemoresistance in tubo-ovarian carcinoma by Olivia D. Lara, Elke Van Oudenhove, Luiza Pereira, Selim Misirlioglu, Douglas A. Levine, Kari E. Hacker

“…In vitro experiments (cell viability assay, Western blot analysis, Calcein AM fluorescence assay, and migration assay) were carried out to determine the functional effects of SPL-108 in TOCs. Findings: Ovarian cancer cell lines OVCAR5 and OVCAR8 expressed higher protein levels of CD44 as demonstrated through Western Blot analysis. …”
Get full text

Does the surgeon’s learning curve impact pentafecta outcomes in radical prostatectomy? a systematic review and meta-analysis by Jose Arnaldo Shiomi Da Cruz, Breno Cordeiro Porto, Bruno Damico Terada, Felipe Giraldo Alvarez Gonçalves, Soraya Hussein Orra, Juan Victor Nabhan Martinez, Carlo Camargo Passerotti, Rodrigo A. S. Sardenberg, Kenneth Nunes Tavares De Almeida, Everson Luiz De Almeida Artifon, Jose Pinhata Otoch

“…Our analysis suggests that reaching a threshold of 100 cases may be necessary to consistently attain optimal functional and perioperative results.…”
Get full text

The comparative analysis of the effectiveness of stimulation of liver regeneration by bone marrow cells and total RNA of these cells by Z. Z. Gonikova, A. O. Nikolskaya, L. A. Kirsanova, M. Yu. Shagidulin, N. A. Onishchenko, V. I. Sevastianov

“…The tRNA from BMCs and BMCs in the indicated doses prevent the risk of the development of lethal outcomes, and also contribute to an earlier (by 10–14 days) normalization of the functional indices of hepatic homeostasis. However, the tRNA from BMCs, compared with BMCs, has a stronger stimulating effect on the recovery processes: it promotes earlier intensification of mitotic activity of hepatocytes and provides a higher rate of recovery of liver mass.Conclusion. …”
Get full text

The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review by Abebe Feyissa Amhare, Abebe Feyissa Amhare, Lichun Qiao, Huan Deng, Jinyan Lin, Jun Wang, Wei Wang, Jing Han

“…Future work should focus on long-term validation, functional outcome measures, and development of smart, adaptive materials to support clinical translation.…”
Get full text