Boosting Hydroxyl Radical Generation with Nitrogen Vacancy–Modified Carbon Nitride for Triggering Dual Damage of Cancer Nucleus DNA–Mitochondria against Hypoxic... by Zhang Y, Liu M, Xue S, Li N, Hong J, Gu J, Ren X, Li H, Xu J, Zhang C, Liang T, Zhao B, Wang X

“…Under illumination, NV-PCN generates a burst of •OH around the nuclei and mitochondria of Cal-27 cells, which effectively kills the cells via synchronously leading to DNA damage and mitochondrial dysfunction. Compared to the conventional photosensitizer chlorin e6, NV-PCN–based PDT exhibits excellent anticancer performance in vitro and in vivo, highlighting its potential as a next-generation therapeutic agent.Conclusion: Collectively, the high •OH-generation efficiency, strong anticancer activity, and overall safety of the O2-independent nanoparticle opens up new avenues for in-depth study on carbon nitride-based cancer PDT strategies. …”
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The contribution of modifiable risk factors to the formation of cardiovascular remodelling and vegetative balance in patients with essential hypertension by V. V. Syvolap, O. V. Vizir-Tronova

“…The addition of any single RF in patients with EH is associated with an increase in the size of left atrium, left ventricular myocardial mass index mainly due to thickening of the interventricular septum, diastolic dysfunction of the left ventricle. The addition of any RF in the examined patients is accompanied by a tendency to decrease in blood flow in all vessels basins, but mainly in the common carotid arteries. …”
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Rosacea pathogenesis and topical treatment options – a review by Aleksandra Okońska, Julia Kozakiewicz, Michał Ziemba, Joanna Kałuska, Tomasz Suprun, Aleksandra Sokół, Klaudia Mościszko, Katarzyna Nowicka, Wiktor Klimek, Maria Majewska

“…Summary: Rosacea is driven by multifactorial mechanisms, including neurovascular hyperreactivity, immune system dysregulation, sebaceous gland dysfunction, microbial imbalances, and genetic predisposition. …”
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Outcomes of Percutaneous Peritoneal Dialysis Catheters Insertion by Interventional Radiologists: A Single-Institution Experience by Khadijah Alhussaini, Shaima Abulqasim, Abdulaziz Mohammad Al-Sharydah, Elwaleed Elhassan, Mohammad Arabi

“…Objectives This article evaluates the short- and long-term outcomes of percutaneous peritoneal dialysis (PD) catheters inserted by interventional radiology service and analyzes the factors that affect the sustainability of patent and functional PD catheters. Materials and Methods Retrospective single-institution study between April 2015 and February 2021. …”
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Aortic Valve Reinterventions after Ozaki: Clinical Case Series from Four Centers by S. T. Enginoev, I. I. Chernov, R. N. Komarov, V. A. Belov, V. B. Arutyunyan, B. K. Kadyraliev, A. P. Semagin, D. V. Kuznetsov, A. A. Zybin, A. M. Ismailbaev, U. K. Abdulmedzhidova, B. M. Tlisov, A. B. Gamzaev

“…The main causes of dysfunction were IE (six patients) and leaflet rupture in the commissural area (five patients). …”
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Impact of cognition and psychoemotional status on falls in multiple sclerosis by R. Godelienė, E. Sukockienė, V. Danielius, V. Stankunavičiūtė, D. Mickevičienė

“…More than 50% of multiple sclerosis patients experience falls associated with accumulating disability, bladder dysfunction, and imbalance. However, impact of psychoemotional factors, including depression, anxiety, and cognition, on the risk of falling has not been studied in Lithuania so far. …”
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Utilization of dexrazoxane in patients treated with doxorubicin: a retrospective, propensity matched analysis of cardiac function and toxicity by Zachary M. Neiman, Carlo S. Legasto, Alan K. Chin, Tiffany Guan, Brian C. Schulte, Brian C. Schulte

“…IntroductionDexrazoxane (DZR) has been used to prevent cardiotoxicity from doxorubicin (DOX), particularly in younger patients with cancer and those with pre-existing cardiac dysfunction. Herein, we sought to further define the role of DZR by evaluating its capacity to mitigate cardiotoxicity in patients actively receiving DOX, while also assessing concomitant toxicities.Materials and methodsWe conducted a retrospective, propensity-matched cohort study at a single academic center, comparing outcomes between patients treated with DZR plus DOX and those who received DOX alone. …”
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A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway by Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun

“…Context The decline in ovarian reserve is a major concern in female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. Although ginsenoside Rg1 is known to modulate mitophagy, its effectiveness in mitigating ovarian reserve decline remains unclear.Objective To investigate the role of ginsenoside Rg1 in promoting mitophagy to preserve ovarian reserve.Materials and methods Ovarian reserve function, reproductive capacity, oxidative stress levels, and mitochondrial function were compared between ginsenoside Rg1-treated and untreated naturally aged female Drosophila using behavioral, histological, and molecular biological techniques. …”
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The Effectiveness of Acth Therapy According to Etiology in Patients with West Syndrome and Its Long-Term Effects on Bone Mineral Metabolism and Adrenal Pathway by Mesut Güngör, Mine Düzgöl, Hülya Maraş Genç, Emek Uyur Yalçın, Filiz Mine Çizmecioğlu Jones, Bülent Kara

“…It was demonstrated that there is no risk in terms of bone metabolism and adrenal dysfunction in the subacute-chronic period after ACTH treatment.…”
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The role of sTNFSF14 in the liver mitochondrial dynamics in obese patients by A. A. Komar, D. A. Skuratovskaia, M. A. Vulf, H. Q. Vu, A. Darinskas, N. D. Gazatova, N. M. Todosenko, P. A. Zatolokin, E. V. Kirienkova, L. S. Litvinova

“…The pathogenesis of nonalcoholic fatty liver disease (NAFLD), which develops in obesity and type 2 diabetes mellitus (T2DM), is associated with the effects of inflammatory factors on the liver parenchyma and liver mitochondrial dysfunction.Aim. To determine the role of sTNFSF14 in the regulation of liver mitochondrial biogenesis in obese patients with and without T2DM.Materials and methods. …”
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Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

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Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases by T. O. Holovko, L. F. Bohmat, N. S. Shevchenko, Yu. V. Volkova, L. L. Sukhova, O. S. Pavlova

“…It is known that the dysfunction of the endothelium has crucial role in many pathological conditions and underlines adverse cardiovascular events. …”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…Introduction: Temporomandibular Disorders (TMD) encompass a range of conditions affecting the joint and surrounding structures, often resulting in pain, restricted movement, and dysfunction. Arthrocentesis involves the insertion of a single needle into the joint space, allowing for irrigation, lavage, and aspiration of the joint. …”
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Cardioprotective effects of the estrogen receptors modulators in the conditions of experimental acute myocardial infarction by K. V. Levchenko, S. V. Gorbachova

“…Aim of study – to evaluate the SERM cardioprotective effects in the conditions of acute myocardial infarction modelling with the use of the ST2 marker. Materials and methods: The experimental part of the work was performed on 120 mature rats - males weighing 190–230 grams. …”
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The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers by Viorela Romina Murvai, Casandra-Maria Radu, Radu Galiș, Timea Claudia Ghitea, Anca-Florina Tătaru-Copos, Alexandra-Alina Vesa, Anca Huniadi

“…Objective: This study aimed to evaluate the impact of inherited thrombophilic mutations on first-trimester screening outcomes, focusing on their relationship with maternal biomarkers and ultrasonographic parameters. <i>Materials and Methods</i>: A prospective observational study was conducted on 105 pregnant women during the first trimester (10–13 weeks of gestation). …”
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Application of T1 MRI in takotsubo cardiomyopathy by Liene Balode, Robert Kelly, David Gamble, Dana Dawson, James Ross

“…Introduction: Takotsubo cardiomyopathy is a temporary and severe left ventricular dysfunction caused by extreme emotional or physical stress, which confers significant mortality and morbidity.1 Cardiac magnetic resonance (CMR) sequences have been analysed to determine their diagnostic abilities in takotsubo patients. …”
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A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria by Lamia Abir Tazi, Yasmina Benabdesslem, Sabrina Amara, Kadda Hachem

“…These disorders involve persistent digestive symptoms indicative of digestive tract dysfunction.Materials and Methods: A survey examining the utilisation of probiotics and medicinal plants as supplementary treatments was conducted on 160 patients with GI disorders at healthcare institutions in Saïda from March to April 2023 using questionnaires that had been previously adapted and tested for reliability with Cronbach’s alpha test. …”
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Frequency of detection and factors of elevated levels of diabetes-associated autoantibodies in the blood of patients with clinical type 2 diabetes mellitus by Y.A. Saienko, B.M. Mankovsky

“…The purpose of the study: to assess the frequency of detecting elevated GADA autoantibodies in patients with a clinical course of T2DM and to determine their association with clinical, metabolic, and social characteristics. Materials and methods. The study included 48 participants with clinically diagnosed T2DM, 30 (62.5 %) men and 18 (37.5 %) women. …”
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Relation between Uric Acid Levels, Creatinine and Body Mass Index in Hypertensive Women and Men by Sklyarov E., Pylypiv O., Gutor T.

“…Materials and methods. The study involved 74 patients with hypertension (37 females and 37 males) aged 30–78 years (mean age – 59.7 ± 1.7 years). …”
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Ustilaginoidin D Induces Acute Toxicity and Hepatotoxicity in Mice by Bo Wang, Xiaolong Bai, Min Zhang, Xiangxiang Liu, Muhammad Zulqar Nain Dara, Lingjing Liu, Mingming Ou, Dayong Li, Jiyang Wang, Ling Liu, Wenxian Sun

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