Physical Activity vs. Pharmacotherapy in PCOS Treatment: A relief of Clinical Evidence on Exercise and Metformine Efficacy by Magdalena Bartold, Janina Pohrybieniuk, Marta Piotraszewska, Maria Grys, Filip Kochański, Karolina Wołk, Magda Skudzińska, Aleksandra Jaskulska, Dominika Błonka, Jan Pietrzak

“… Introduction  Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, characterized by hormonal imbalance, insulin resistance, and ovulatory dysfunction. It presents with a wide range of symptoms, including menstrual irregularities, hyperandrogenism, and metabolic disturbances, often leading to infertility and increased long-term cardiometabolic risk. …”
Get full text

Diagnostic and prognostic value of inflammatory indices in patients with prediabetes and type 2 diabetes mellitus by Z.O. Shaienko, H.Yu. Morokhovets

“…Type 2 diabetes mellitus (T2DM) is cha­racterized by chronic low-grade inflammation, which significantly contributes to the development of insulin resistance and progressive metabolic dysfunction. Inflammatory indices derived from complete blood count parameters may serve as accessible and cost-effective tools for assessing meta-inflammation. …”
Get full text

INFLUENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE KISS1 GENE ON THE DEVELOPMENT OF ANOVULATORY INFERTILITY IN WOMEN by Анна Николаевна Лысова, Елена Петровна Шатунова, Елена Григорьевна Зарубина

“…Objective – to study the effect of single nucleotide polymorphisms of the KISS1 gene on the level of sex hormones, regulatory peptins and the development of anovulatory infertility in women. Materials and methods. The study involved 73 women: group I included patients with a confirmed diagnosis of anovulatory infertility and menstrual dysfunction in the form of oligomenorrhea and amenorrhea; group II (control) consisted of 28 patients who had one or more normal births with a healthy child in their anamnesis. …”
Get full text

Marker profile of myocardial remodeling in different etiopathogenetic forms of arterial hypertension in the experiment by Yu. M. Kolesnyk, M. I. Isachenko

“…The aim was to determine the morphodensitometric parameters of cardiomyocytes and features of the marker profile of remodeling in the left ventricular myocardium of rats with experimental hypertension of different etiopathogenetic forms. Materials and methods. The experiment was conducted on 20 male Wistar rats and 10 SHR which were divided into two groups of 10 animals each: the 1st –control; the 2nd – rats of the SHR line (EAH); the 3rd – 10 male Wistar rats with endocrine-salt arterial hypertension. …”
Get full text

Modern View on the Etiology and Methods of Treatment of Bruxism: а Review by Elena V. Terentyeva, Olga Yurova, Anastasia D. Dubinskaya

“…Currently, the prevalence of bruxism ranges from 9 % to 32 % of the total population, of which 6 % to 20 % are adults, while the question of the etiology of bruxism remains open, due to the presence of various theories of the development of this disease. MATERIALS AND METHODS. The search was conducted for the period from 2002 to 2024 in the Medline database using the keyword "bruxism" and in the Elibrary database of the scientific electronic library using the keyword "bruxism". …”
Get full text

The Effectiveness of Acceptance and Commitment-Based Therapy on the Immune Function and Activity Limitations in Patients With Irritable Bowel Syndrome by Sepideh Shakernejad, Javad Khalatbari, Majid-Mahmoud Alilou

“…Introduction: Irritable bowel syndrome is the most common, costly, and disabling dysfunction of the gastrointestinal tract. Mental disorders can be one of the main factors in the onset, continuation, or exacerbation of gastrointestinal signs and symptoms in people with this syndrome. …”
Get full text

Assessment of Cardiovascular Risk in Patients with Fatty Liver: Impact of Hepatic Cirrhosis by Arely Gayosso-Godinez, Raúl Contreras-Omaña

“…Introduction and Objectives: According to the literature, cardiovascular events have been described as the leading cause of death in patients with fatty liver associated with metabolic dysfunction (MASLD). The main objective of this study is to assess and compare cardiovascular risk in two groups of patients: those diagnosed with fatty liver without cirrhosis and those with liver cirrhosis attributable to fatty liver. …”
Get full text

WDJ-S4, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice by Seung-Ju Hwang, Chang-Seob Seo, Dong-Cheol Baek, Tae-Wook Woo, Jing-Hua Wang, Jin-Seok Lee, Yu-Jin Choi, Ji-Yeon Gu, Dong-Seon Kim, Chang-Gue Son

“…Context WDJ-S4, a standardized herbal formula, has been prescribed for refractory functional dyspepsia (FD) in Korea, but the detailed mechanisms are lacking.Objective The present study investigates the acceleration of gastrointestinal (GI) motility by WDJ-S4 and its potential mechanisms.Materials and methods For five days, WDJ-S4 (50, 100 and 200 mg/kg) or mosapride (3 mg/kg) was orally given to BALB/c mice. …”
Get full text

Alterations in the gut microbiome and metabolism with doxorubicin-induced heart failure severity by Qian Wang, Meihua Liu, Meihua Liu, Tianpei Liu, Tianpei Liu, Long Li, Chenyang Wang, Xiaolin Wang, Shuling Rong, Xuedong Zhou

“…ObjectiveThis study aimed to explore the changes in gut microbiota and its metabolites in different pathophysiological stages of doxorubicin (DOX)-induced heart failure (DIHF) and the relationship between gut microbiota and metabolites in various degrees of DIHF.Materials and methodsC57BL/6 J mice were injected intraperitoneally with 5 mg/kg of DOX once a week for 5 consecutive weeks. …”
Get full text

Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy by Qinyue Guo, Qindong Shi, Huixia Li, Jiali Liu, Shufang Wu, Hongzhi Sun, Bo Zhou

“…We tested the effects of TUDCA on autophagic dysfunction in obese mice. Material and Methods. 500 mg/kg of TUDCA was injected into obese mice, and metabolic parameters, autophagy markers, and insulin signaling molecular were assessed by Western blotting and real-time PCR. …”
Get full text

Correlation of Serum Nitric Oxide, High Sensitivity C-reactive Protein and Lipid Parameters in Diabetics with and without Coronary Artery Disease by Kavitha M. M, J. G Ambekar, S. V Kashinakunti, Nilima Dongre

“…Uncoupling of endothelial nitric oxide synthase enzyme occurs in the blood vessels of diabetics leading to endothelial dysfunction and excessive production of superoxide anion causing decreased bioavailability of NO. …”
Get full text

Left ventricular remodeling in patients with right ventricular myocardial infarction by M. T. Beyshenkulov, Z. M. Chazymova, A. S. Abylgazieva, K. R. Kaliev

“…Significant signs of diastolic dysfunction (RV end-diastolic area 29.21±2.0 cm2) were found in group 2 on the third day after MI. …”
Get full text

Long-term results of aortic valve replacement with xenogenic pericardial stentless prosthesis BioLAB KB/A by S. I. Babenko, R. M. Muratov, N. N. Soboleva, D. A. Titov, N. P. Bakuleva, M. I. Fedoseikina

“…Freedom from prosthetic valve dysfunction due to structural degeneration was 9,58±1,83 years.Conclusion. …”
Get full text

EFFECTS OF TRIMETAZIDINE ON THE TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE by Yu. N. Fedulaev, N. S. Pavlyuchenko, T. V. Pinchuk, S. Kh. Galachieva, A. A. Kozina, V. N. Ryzhenkov

“…Material and methods. Patients with IHD and HT (n=154) were divided into two treatment groups. …”
Get full text

Clinical significance of high-sensitivity C- reactive protein in systemic sclerosis by T. A. Nevskaya, A. A. Novikov, E. N. Alexandrova, E. S. Mach, M. E. Zapryagaeva, A. I. Speransky, N. G. Guseva, L. P. Ananjeva

“…Relationship with clinical features of the disease, endothelial dysfunction, capillaries structure changes, sub-clinical atherosclerosis, total coronary risk and some traditional cardiovascular risk factors was analyzed. …”
Get full text

Role of inflammation in the development of cardiac autonomic disfunction in patients with systemic lupus erythematosus by D. S. Novikova, T V Popkova, T A Panafidina, E L Markelova, Y O Korsakova, A A Novikov, E N Alexandrova, Z S Alekberova, E S Mach, E L Nasonov

“…Material and methods. 75 female pts with SLE aged before 55 years were included. …”
Get full text

CARDIO-RESPIRATORY SYSTEM IN LATE REHABILITATION PERIOD AFTER CORONARY ARTERY BYPASS GRAFT SURGERY by E. Yu. Sabirova, E. N. Chicherina

“…Mean LF parameters appeared normal; abnormal LF results were observed only in 4 participants (16%; 2 with obstructive respiratory dysfunction and 2 with restrictive respiratory dysfunction). …”
Get full text

Endothelial function changes in paroxysmal atrial fibrillation and treatment with propafenone by V. I. Podzolkov, A. I. Tarzimanova

“…Changes in endothelium vascular motion function and biochemical markers of endothelial dysfunction were assessed at inclusion and in 12 months of therapy.Results. …”
Get full text

The state of the membrane potential of the mitochondria of blood leukocytes in acute coronary syndrome by P. A. Semenova, V. A. Nevzorova, N. G. Plekhova, I. N. Chernenko, E. K. Lemtyugova

“…The established relationship between  MPMP indices  in MI and the content  of TrI can  be considered as a confirming fact of the participation of cells with mitochondrial dysfunction in the development of ischemic necrosis. …”
Get full text

SPECIAL PROPERTIES OF THE LEFT VENTRICLE MYOCARDUM REMODELING IN ATHLETES WITH ARTERIAL HYPERTENSION by N. V. Fomina, O. A. Ronzhina, S. A. Smakotina

“…In sportsmen without AH there is no diastolic dysfunction either with or without LVH.…”
Get full text