Expert consensus on the management of pharmacodynamic breakthrough-hemolysis in treated paroxysmal nocturnal hemoglobinuria by David Dingli, Carlos De Castro III, Jamie Koprivnikar, Austin Kulasekararaj, Jaroslaw Maciejewski, Brian Mulherin, Jens Panse, Vinod Pullarkat, Alexander Röth, Jamile Shammo, Louis Terriou, Ilene Weitz, Irina Yermilov, Sarah Gibbs, Michael Broder, David Beenhouwer, David Kuter

“…Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, non-malignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, and bone marrow dysfunction. The development of complement inhibitors has transformed outcomes for patients with PNH, but patients may still experience pharmacodynamic breakthrough hemolysis (BTH), which can be caused by exposure to a complement amplifying condition (CAC), such as vaccination, infection, or surgery.Materials and methods: A 13-member expert panel used a validated methodology (a RAND/UCLA modified Delphi panel) to develop consensus on how to classify pharmacodynamic BTH in patients with complement-inhibitor treated PNH. …”
Get full text

The ecotoxicity and social impacts of industrial pollution: Insights on intervention and bioremediation strategies in Africa by Gloria Ifeoma Ujuagu, Onome Ejeromedoghene, Peter Olusakin Oladoye, Charles Obinwanne Okoye, Yakubu Adekunle Alli, Mayowa Ezekiel Oladipo, Jintu Gu

Get full text

Prognostic value of short-term trajectories of left ventricular ejection fraction in patients with first myocardial infarction and percutaneous coronary intervention by T. M. Timofeeva, Zh. D. Kobalava, A. F. Safarova, M. F.E. Cabello, Zh. G. Tigay

“…In patients with first AMI and left ventricular systolic dysfunction, periprocedural evaluation of LVEF is reasonable to stratify the risk of adverse cardiovascular outcomes.…”
Get full text

Metabolic storm in psoriatic arthritis: a cardiovascular time bomb? by Eugeniu Russu, Mircea Betiu, Alexandru Corlateanu, Lia Chislari, Larisa Rotaru, Liliana Groppa

“…Chronic inflammation, adipokine imbalance, and endothelial dysfunction contribute to accelerated atherosclerosis in this population. …”
Get full text

Comparison of Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment intensive care unit scoring system as mortality predictors in intensive care... by Lokesh SB, Latha V

“…Background: Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection. …”
Get full text

Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary dise... by Ludmila V. Shogenova

“…Complex therapy improves the clinical condition of patients, reduces signs of hypoxemia and hypercapnia, vascular endothelial dysfunction, metabolic disorders and increases tolerance to physical activity by normalizing gas exchange in the lungs, increasing oxygen delivery to tissues, reducing the shunt fraction, and restoring metabolism.…”
Get full text

Reinterventions in patients with congenital aortic stenosis and a commissurotomy by Christina Christersson, Camilla Sandberg, Daniel Rinnström, Peder Sörensson, Bengt Johansson, Zacharias Mandalenakis, Johan Ljungberg, Alexandra Trzebiatowska-Krzynska, Mostafa Mahmoud, Joanna Hlebowicz

“…The prevalence of left ventricular dysfunction and New York Heart Association class >1 was low.Conclusion Most (54.7%) patients with a commissurotomy, more than half of them within 30 years and eventually all will need a reintervention. …”
Get full text

Influence of B16/F10 melanoma growth variant on calcium levels in mitochondria in various organs of female mice by O. I. Kit, E. M. Frantsiyants, I. V. Neskubina, E. I. Surikova, I. V. Kaplieva, V. A. Bandovkina

“…To analyze the calcium levels in mitochondria of cells in different organs in standard and stimulated growth of experimental В16/F10 melanoma. Materials and Methods. The study included female С57ВL/6 mice (n=168). …”
Get full text

Sexual differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia by E. G. Kornetova, V. V. Tiguntsev, A. N. Kornetov, A. A. Goncharova, O. A. Lobacheva, A. A. Davydov, S. A. Khardikova, S. A. Ivanova, A. V. Semke

“…The goal was to identify gender differences in the clinical features of antipsychotic-induced hyperprolactinemia in patients with schizophrenia.Materials and methods. 98 patients from the Department of Endogenous Disorders of the Research Institute of Mental Health Clinic in Tomsk were examined. …”
Get full text

Characterizing outcomes in a large cohort of latinx patients with autoimmune hepatitis by Eleanor Belilos, Jessica Strzepka, Ethan Ritz, Nancy Reau, Costica Aloman

“…Latinx patients were more likely to have metabolic dysfunction-associated steatotic liver disease (MASLD) (p = 0.004), and had higher Fibrosis-4 (FIB-4) (p = 0.0279) and AST-to-Platelet-Ratio-Index (APRI) (p = 0.005) at one year. …”
Get full text

Rosuvastatin mitigates blood–brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels by Qin Shen, Qian Yu, Taojiang Chen, Lijuan Zhang

“…However, its potential neuroprotective role in SAE remains unclear. Materials and methods SAE models were established using the cecal ligation and puncture (CLP) method. …”
Get full text

The influence of systemic inflammatory markers on the development of obstetrical complications in pregnant women with chronic obstructive pulmonary disease by S. M. Heriak, O. I. Oleksiak

“…The aim of our study is to establish the features of changes in the cytokine profile in pregnant women with COPD and their role in the development of obstetrical and perinatal complications. Materials and methods. 77 pregnant women with clinically and instrumentally verified signs of COPD were examined, who were divided into 2 subgroups depending on the degree of bronchial obstruction: IA – 43 pregnant women with FEV1 ≥80 %, IB – 34 pregnant women with FEV1 50–79 %. …”
Get full text

Reliability of lateral cephalometric radiographs in the assessment of the upper airway: a systematic review by M. E. Balashova, Z. S. Khabadze, I. A. Voronov, I. N. Bagdasarova, N. N. Fedotova

“…To analyze the literature on the effectiveness of the using Lateral Cephalogram in the assessment of the upper airway.Materials and methods. Electronic search of articles was carried out using search engines and databases: Cyberleninka, eLIBRARY, Google Scholar, Pub Med, SCOPUS. …”
Get full text

A dimensional approach to assessing delirium in COVID-19 in the elderly by V. E. Pashkovskiy, N. N. Petrova, M. S. Sivashova, A. Ya. Vuks, G. A. Prokopovich

“…The aim of the study was to investigate the structure of delirium in elderly patients with different outcomes of coronavirus infection.Materials and Methods. The study was carried out on the basis of Hospital for War Veterans, St. …”
Get full text

Recombinant human urinary trypsin inhibitor improves the immunological function of splenic dendritic cells in mice with acute lung injury by Tong Wang, Wenna Liu, Jun Li, Yongli Wan, Hang Su, Anlong Qi

“…Materials and methods RhUTI was administered to mice, and splenic CD11c + DCs were isolated and assessed using flow cytometry for apoptotic or phenotypic analysis. …”
Get full text

The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients by Veronika Walter, Ekaterina Hinrichs, Tarek Alloush, Aritz Perez Ruiz de Garibay, Gregor Warnecke, Wiebke Sommer, Hanna Gravert, Christina Grothusen, Janine Becker, Alexander Thiem, Bernd Panholzer

“…A multimodal approach at targeting organ dysfunction seems to be a promising strategy, encompassing both hemodynamic support as well as differentiated organ replacement therapy. …”
Get full text

ROLE OF COMBINED THERAPY IN THE TREATMENT OF PATIENTS WITH INFERTILITY AND REPRODUCTIVE FAILURES by E. V. Vartanyan, E. A. Devyatova, K. A. Tsaturova, D. R. Aglyamova

“…In hysteroscopy, chronic endometritis (CE) is diagnosed in one of three women with reproductive dysfunction. Search for novel therapeutic strategies aimed at improving the endometrium condition to overcome the RIF, remains an important goal of reproductive medicine.Aims of the study: 1) identify clinical markers of infertility and RIF; 2) characterize the structural and functional changes in the endometrium of women with infertility and RIF; 3) test the efficacy of the proposed combined therapy in correcting of «uterine factor» of infertility in women with previous in vitro fertilization (IVF) failures.Materials and methods. …”
Get full text

Case report: hyponatraemia in Wolfram syndrome by Khadijah Tukur, Zakari Sani

“…Results and Discussion: Hyponatraemia is a common clinical problem in patients with Wolfram syndrome and requires careful management because most patients have concurrent diabetes mellitus and bladder dysfunction.3Arginine vasopressin deficiency, a component of Wolfram syndrome, leads to polyuria. …”
Get full text

The length of the warm ischemic interval in lung donation after circulatory death does not impact post-transplantation outcomes by Amer Alzahrani, MD, Kentaro Noda, PhD, Ernest G. Chan, MD, John P. Ryan, PhD, Masashi Furukawa, MD, PhD, Pablo G. Sanchez, MD, PhD

“…There were no observed associations between agonal or warm ischemic times and post-transplant outcomes, including primary graft dysfunction, ventilator dependency, and acute rejection. …”
Get full text

Oxidative/Nitrosative Stress and Brain Involvement in Sepsis: A Relationship Supported by Immunohistochemistry by Giuseppe Bertozzi, Michela Ferrara, Mariagrazia Calvano, Natascha Pascale, Aldo Di Fazio

“…<i>Background and Objectives</i>: A large amount of recent evidence suggests that cellular inability to consume oxygen could play a notable part in promoting sepsis as a consequence of mitochondrial dysfunction and oxidative stress. The latter could, in fact, represent a fundamental stage in the evolution of the “natural history” of sepsis. …”
Get full text