Post‐hoc analysis of the tofogliflozin post‐marketing surveillance study (J‐STEP/LT): Tofogliflozin improves liver function in type 2 diabetes patients regardless of BMI by Hiroyuki Uchinuma, Mitsunori Matsushita, Masaya Tanahashi, Hideki Suganami, Kazunori Utsunomiya, Kohei Kaku, Kyoichiro Tsuchiya

“…Weight loss has proven effective in treating metabolic dysfunction‐associated steatotic liver disease (MASLD) in obese patients with type 2 diabetes, with sodium‐glucose cotransporter 2 (SGLT2) inhibitors showing promising results. …”
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Impact of aortic valve calcification volume on left ventricular systolic function in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation by Helen S. Anwar, Magdy Algowhary, Mohamed Aboel-Kassem F. Abdelmegid, Hatem A. Helmy, J.M. Montero-Cabezas, Frank Van Der Kley

“…Materials and methods: An observational study of 75 patients with severe AS and LV ejection fraction (EF) ≤ 50 % who underwent TAVI. …”
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Outlook for the Use of Neurodevelopmental Therapy in Children with Perinatal Central Nervous System Damage: a Review by Maya A. Khan, Elena V. Kostenko, Natalya A. Mikitchenko, Maria G. Degtyareva, Zareta Kh. Shungarova

“…There was a decrease in the manifestations of oral motor dysfunction, salivation, and improved chewing when using this method. …”
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A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a p... by Sergio Acin, Alejandro Mejia-Garcia, Geysson Javier Fernandez, Norman Balcazar

“…Remarkably, the extract downregulates the expression of genes involved in lipid metabolism, adipogenesis, and adipocyte fat load, such as PRKAR2B, LPIN1, FABP4, Scd1, MC5R, CD36, PEG10, and HMGCS1.Discussion and Conclusions Our study shows that Eucalyptus tereticornis extract is a promising option for treating adipocyte tissue dysfunction derived from obesity.…”
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Ways to optimize infusion therapy for diabetic ketoacidosis by M. I. Neimark, E. A. Kloster, A. A. Bulganin, A. E. Zavyalov

“…The effectiveness of infusion therapy in the treatment of diabetic ketoacidosis is determined by the functional state of the endothelium.The objective was to evaluate the effectiveness of meglumine sodium succinate used in the infusion therapy of diabetic ketoacidosis for correction of endothelial glycocalyx dysfunction Materials and methods. The prospective study included 50 patients with diabetic ketoacidosis, divided into 2 groups – the first, where 0.9% sodium chloride was used as an infusion solution, the second, where meglumine sodium succinate (Reamberin) was added to the infusion program at a daily dose of 10 ml /kg. …”
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The protective properties of resveratrol against glycerol-induced acute kidney injury in rats by Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh

“…Histopathologically, tubule necrosis, myoglobin cast formation and glomerular atrophy increased in the glycerol group and reduced in animals that received RSV.Conclusion: In the glycerol-induced AKI rat model, RSV administration alleviated renal dysfunction by reducing oxidative stress and inflammatory responses.…”
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Improved detection of air trapping on expiratory computed tomography using deep learning. by Sundaresh Ram, Benjamin A Hoff, Alexander J Bell, Stefanie Galban, Aleksa B Fortuna, Oliver Weinheimer, Mark O Wielpütz, Terry E Robinson, Beverley Newman, Dharshan Vummidi, Aamer Chughtai, Ella A Kazerooni, Timothy D Johnson, MeiLan K Han, Charles R Hatt, Craig J Galban

“…<h4>Background</h4>Radiologic evidence of air trapping (AT) on expiratory computed tomography (CT) scans is associated with early pulmonary dysfunction in patients with cystic fibrosis (CF). However, standard techniques for quantitative assessment of AT are highly variable, resulting in limited efficacy for monitoring disease progression.…”
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Prevalence of Microalbuminuria in Essential Hypertension and its Association with Coronary Artery Disease: A Cross-sectional Study by JS Dhadwad, Kunal Modi

“…Microalbuminuria, an indicator of endothelial dysfunction, has been linked with hypertensive nephropathy as well as cardiovascular disease. …”
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PECULIARITIES OF OXYGEN TRANSPORT FUNCTION IN CHILDREN WITH ACUTE RESPIRATORY DISEASES by Oleksandr H. Buriak, Yurii M. Nechytailo

“…Cluster analysis of MC and SaO2 indicators shows a relationship between them based on slowed down peripheral blood flow, probably due to endothelial dysfunction. Conclusions. In children with CAP and AB, even in period of early convalescence, vascular disorders of the MC bed in the form of spasms of arterioles and capillaries, reducing the number of functioning capillary loops, tortuosity of venules could be present. …”
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Course of arterial hypertension during breast cancer chemotherapy with anthracyclines by E. N. Berezikova, S. N. Shilov, A. A. Popova, M. N. Neupokoeva, A. T. Teplyakov, E. V. Grakova, K. V. Kopeva, V. V. Kalyuzhin, A. Yu. Yushin

“…A significant relationship between pre-existing AH and the development of left ventricular systolic dysfunction 12 months after the completion of chemotherapy (p = 0.01) was found. …”
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Myocardial Hibernation in Patients with Arterial Hypertension and Ischemic Heart Disease as a Cause of Heart Failure by Barnett O., Kyyak Y., Kyyak H., Kovalyshyn V., Besh D.

“…To determine the dependence of segmental disorders of the left ventricular myocardial contractility (hypokinesia, akinesia, dyskinesia) on the presence of hybridized cardiomyocytes and to reveal the duration of their life. Materials and methods. For 36 patients with hypertension and coronary artery disease were examined, were examined the ultrastructure of myocardial biopsy material (n = 10) obtained during coronary artery bypass graft (CABG) and aneurysmectomy, as well as express neoplastic lesions (n​​= 26) in those who died of heart attack. …”
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Outpatient diagnosis of endogenous intoxication in surgery by A. A. Solomakha, A. P. Vlasov, V. I. Gorbachenko

“…In recent years, there has been an increase in the number of patients with purulent surgical diseases with severe endogenous intoxication and renal dysfunction. The problem of early diagnosis of purulent diseases is still not completely solved. …”
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Infectious complications in patients with multiple myeloma on first chemotherapy cycle by A. A. Novikova, G. A. Klyasova, E. O. Gribanova, V. A. Okhmat, V. V. Ryzhko, V. G. Savchenko

“…Additional risk factors for infections at admission were Durie–Salmon stage III MM, paresis, lower extremity paraplegia and dysfunction of the pelvic organs, whereas during treatment – ISS stage III MM and renal failure. …”
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Predictors of hepatic steatosis in living liver donors by M. G. Minina, D. V. Voronov, A. A. Nevredimov, E. A. Tenchurina

“…Macrosteatosis (&gt;50%) is associated with primary graft dysfunction and may reduce long-term recipient survival.Objective: to identify predictors of macrovesicular steatosis (&gt;50%) by analyzing donor characteristics.Materials and methods. …”
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Serum levels of soluble endoglin in patients with systemic lupus erythematosus: association with disease activity and neuropsychiatric manifestations by T.V. Stepaniuk, S.V. Shevchuk

“…In the Q4 group, the proportion of patients with confirmed anxiety disorders, depressive disorders, and cognitive dysfunction was statistically significantly higher by 2.4, 5.52, and 2.74 times, respectively (p < 0.05), compared to the Q1 group. …”
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INVESTIGATION OF THE EFFECTS OF CHLORPYRIFOS AND TANNIC ACID APPLIED TO HEK 293 CELLS IN DIFFERENT DOSES AND TIMES ON CELL VITALITY by Sevil Erol, Bahar Öztürk Kurt, Bircan Dinç, Semra Özdemir

“…Pesticides are risk factors for cancer, neurodegenerative diseases, neurotoxicity, reproductive dysfunction and deterioration of many organ functions. …”
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Characteristics of T-cell immunity and level of the natural killer cells content in COVID-19 convalescents with carbohydrate metabolism disorders by K. S. Savchuk

“…COVID-19 causes various consequences, often manifested by the endocrine system dysfunction. The rationale for our study is insufficient data on T and NK cell immunity in patients with hyperglycemia after COVID-19. …”
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EVALUATING THE EFFECTIVENESS OF TRANSPLANTATION CARE TO THE PATIENTS WITH END-STAGE HEART FAILURE IN SVERDLOVSK REGION by N.F. Klimusheva, E.M. Idov, A.I. Iofin, A.L. Levit, I.Y. Serebryakov, Y.A. Zavershinsky, A.N. Bykov, A.A. Piontek

“…Causes of death in the early postoperative period were: graft dysfunction, heart graft rejection, acute heart failure and cardiac arrhythmias. …”
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Modulation of Rage and CD147 in Cerebral Amyloid Angiopathy <i>in vitro</i> by A. I. Mosiagina, E. B. Boytsova, E. D. Khilazheva, E. A. Teplyashina, A. V. Morgun, A. B. Salmina

“…The accumulated clinical data indicates that an important contribution to the pathogenesis of AD is made by neurovascular unit dysfunction, including disruption in permeability of the blood-brain barrier (BBB), microcirculation, and metabolic coupling of cells.Aim. …”
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Βeta-adrenergic receptor reactivity of erythrocyte membranes in patients with left or right atrial dilatation against the background of atrial fibrillation by E. F. Muslimova, V. O. Popova, T. Y. Rebrova, E. A. Archakov, R. E. Batalov, S. A. Afanasiev

“…This contributes to aggravation of myocardial contractile dysfunction and development of arrhythmias, including atrial fibrillation (AF). …”
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