Treatment challenges and survival analysis of human epidermal growth factor receptor 2-positive breast cancer in real world by Praveen Adusumilli, Meher Lakshmi Konatam, Sadashivudu Gundeti, Stalin Bala, Lakshmi Srinivas Maddali

“…Seven patients (9.45%) developed Grade II reversible diastolic dysfunction. Grade II/III peripheral neuropathy due to paclitaxel is the main adverse effect seen in 21 patients. …”
Get full text

Identification of genetic markers associated with cisplatin-induced toxicity using public genomic databases by Suvam Banerjee

“…Mutation analysis revealed a higher frequency of DPYD and UGT1A1 variants in the high-toxicity group.3 Pathway enrichment analysis implicated oxidative stress and mitochondrial dysfunction as key mechanisms contributing to cisplatin toxicity. …”
Get full text

Kidneys functional state in patients suffered purulent pyelonephritis by L. A. Sinyakova, E. V. Bernikov, O. B. Loran

“…During the 7-year observation of patients, it was found that a more pronounced renal dysfunction and perfusion occurred during all periods of observation after undergoing open surgery according to Doppler sonography. …”
Get full text

Prevalence of Dry Eyes in Postmenopausal Females in Hadoti Region of Rajasthan by Jaishree Singh, Ashok Kumar Meena, Tarun Gupta, Ekta Garg, Pushkar Dhir, Neeraj Aggarwal

“…All three tests were reliable in diagnosing dry eye as each had p value < 0.001. Meibomian Gland Dysfunction was present in 10%of Dry eye positive females. …”
Get full text

Obstetric and antenatal risk factors for intrauterine growth restriction by A. M. Hromova, V. A. Berezhna

“…Important antenatal risk factors for IUGR were diagnosed with ultrasound IUGR or low weight (49.2 %), placental dysfunction with blood flow disorders (42.86 %) or without (28.57 %), malnutrition (28.57 %) and hypoplasia of the placenta (12.7 %). …”
Get full text

Emergency thyroidectomy for poorly controlled hyperthyroidism in the context of war in Ukraine by S. I. Savoliuk, A. Ye. Kovalenko, A. V. Zabronskyi

“…All patients underwent a comprehensive clinical and instrumental examination, an assessment of the clinical manifestations of the disease was carried out depending on the wartime migration, the nature of surgical treatment, and the immediate results of the postoperative period. Laryngeal dysfunction, hypocalcemia, hematoma, and bleeding were recorded. …”
Get full text

Clinical characteristics of the periodontal status of patients with diseases of the gastrointestinal tract with dysbiosis by A. A. Ivanova, P. P. Bessonov, N. G. Bessonova, K. M. Nikolaeva

“…In addition, every third person examined had temporomandibular joint (TMJ) dysfunction associated with tooth loss.   Conclusions. …”
Get full text

Research the therapeutic, physicochemical, and pharmaceutical properties of the active compounds found in Tribulus terrestris (TT) by Roohallah Yousefi, Ali Jamshidi

“…The physicochemical and pharmacological characteristics of Tribulus terrestris are currently being studied.Methods and Materials: We utilized the PubChem database to gather data on the studied compounds, including their formulas and structures. …”
Get full text

Pathogenic effects of plasma thiols in patients with psoriasis on background of arterial hypertension by G. I. Makurina

“…These changes characterize the progression of endothelial dysfunction in these patients. Conclusion. Formation of psoriasis progression was significantly associated with low functional capacity glutathione link of antioxidant system and with the inability to adequately replenish the pool of reduced glutathione. …”
Get full text

Evaluation of serum vascular cell adhesion marker-1 in β- thalassemia major patients by Nuha Abd Ali Al-Sarai, Subh Salim Al-Mudallal, Rana Rai’d Najm

“…OBJECTIVES: The aim of this study was to evaluate the level of soluble VCAM-1 in β-thalassemia major patients and to correlate its level with the clinical parameters. PATIENTS, MATERIALS AND METHODS: This case–control study was enrolled on 40 patients with β-thalassemia major. …”
Get full text

LEFT VENTRICLE FUNCTIONAL STATUS DYNAMICS THROUGH VARIOUS ISCHEMIA CLINICAL COURSES AFTER AN ENDURED ACUTE CORONARY SYNDROME by D. A. Shvets, S. V. Povetkin

“…As a result of the comparison of clinical instrumental parameters a global and a segmental LV dysfunctions were discovered among the patients with the aggravated IHD clinic course 24 months after an endured ACS.…”
Get full text

Assessing sexual function and vulvovaginal symptoms in young patients with vulvar dystrophy by A. G. Solopova, E. E. Achkasov, A. D. Makatsariya, I. V. Khamani, T. A. Blbulyan, V. S. Moskvichyova

“…Results. Severe sexual dysfunction (FSFI score 2) was detected in 14 % of cases (n = 8) in group 1 (sclerotic lichen vulva) and 17 % (n = 11) in group 2 (mixed dystrophy). …”
Get full text

Assessment of Etiological Factors Reported in the Literature and Their Impact on TMD Incidence in Young Adults by Julia Wójcicka, Szymon Dudziński, Daniil Charnushevich, Wiktoria Musyt

“… Introduction: Chronic temporomandibular disorders (TMDs) typically result from long-term exposure to factors such as occlusal dysfunction, stress, and parafunctions, and are often associated with older patients. …”
Get full text

Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia by Katsuhiko Naruse, Juria Akasaka, Aiko Shigemitsu, Taihei Tsunemi, Natsuki Koike, Chiharu Yoshimoto, Hiroshi Kobayashi

“…Materials and Methods. Visceral adipose tissue was obtained from the omentum of patients with early ovarian cancer without metastasis. …”
Get full text

Left Atrial Strain by 2D Speckle Tracking Echocardiography in Patients with Systemic Hypertension in Babylon Province by Ali Hamid Abbas Al-Murib, Hassan Salim Al-Jumaily, Zainab Falah Hassan, Shokry F. Al-Saad

“…Earlier detection and treatment of dysfunction can delay or even prevent complications.…”
Get full text

Levothyroxine therapy in pregnancy: Are we overtreating patients? by Vesselina Yanachkova, Radiana Staynova, Daniela Grekova-Kafalova, Valentina Petkova

“…A lack of consensus in current guidelines on diagnosing thyroid dysfunction during pregnancy and administering levothyroxine raises concerns regarding treatment efficacy. …”
Get full text

Echocardiographic Changes in Patients with End-Stage Renal Disease at Initiation of Dialysis by Shabana Nazneen, Muzamil Latief, Manjusha Yadla

“…Patients with chronic kidney disease have a tremendous burden of cardiovascular disease (CVD), and patients with end-stage renal disease (ESRD) are at a greater risk of CVD and deaths. Materials and Methods: In this study, 245 incident dialysis patients were included, and none of the patient was on erythropoietin. …”
Get full text

Laboratory manifestations of fetal inflammatory response syndrome in extremely premature newborns by V.V. Bila

“…Fetal inflammatory response syndrome (FIRS) is a pathological response to changes in the chorion and is manifested by inadequate cytokine production and endothelial dysfunction. Objective of the study: to investigate laboratory changes in extremely premature newborns depending on the presence of FIRS criteria. …”
Get full text

Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise by Roy Januardi Irawan, Joesoef Roepajadi, Heri Wahyudi, Noortje Anita Kumaat, Abdul Rohim Tualeka, Nanda Rimawati, Adi Wijayanto

“…Intense or unaccustomed exercise can cause muscle damage and tissue injury, leading to temporary muscle dysfunction and the release of pro-inflammatory cytokines and free radicals. …”
Get full text

Aspects of cytomegalovirus reactivation in critically ill patients by V. V. Gorbachev, T. I. Dmitrachenko, V. M. Semenov, S. K. Egorov

“…Despite the available evidence, data on reactivation in this group of patients are limited by the relatively small sample size, the variety of patient groups studied, the differences in study methodology, and the variability in reported results, which excludes the possibility of summarizing the results.This study aimed to determine the frequency of reactivation of cytomegalovirus infection in critically ill patients and to identify its main clinical features.Materials and methods. The study included 118 critically ill patients with severe bacterial and viral-bacterial infections accompanied by multiple organ dysfunction. …”
Get full text