Are patients with chronic obstructive pulmonary disease at a greater risk for the development of autoimmune thyroiditis as an adverse event of immunotherapy in non-small cell lung... by Andrej Zecevic, Ana Blanka-Protic, Aleksandar Jandric, Tatjana Adzic-Vukicevic, Tatjana Adzic-Vukicevic

“…During treatment, eight of these patients developed thyroid dysfunction. Patients with COPD were at increased risk of developing autoimmune thyroiditis compared to non-COPD patients (OR 3.9 95% CI 1.135–13.260, p = 0.0227).ConclusionOur study showed that patients dealing with COPD have a 3.9 times greater risk of developing autoimmune thyroiditis as an adverse event during Pembrolizumab treatment compared with patients without COPD.…”
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Non-immunogenic staphylokinase in the high-risk pulmonary embolism treatment with subdural hematoma by S. L. Konstantinov, Zh. Yu. Chefranova, G. I. Stryabkova, S. A. Pribylov, I. B. Kovalenko, E. V. Gavrilyuk, S. V. Ivanov, S. S. Markin

“…To evaluate the safety and efficacy of the non-immunogenic staphylokinase in a patient with a massive high-risk pulmonary embolism (PE) with subdural hematoma.Material and methods. Non-immunogenic staphylokinase (Fortelyzin®, LLC “SuperGene”, Russia) is an original thrombolytic drug with high fibrin selectivity and minimal risk of bleeding. …”
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Why Diabetes Worsens Patient Prognosis: A Literature Review of Cardiovascular and Renal Complications by Magdalena Rafałowicz, Adam Rafałowicz, Urszula, Justyna Wojciechowska, Jakub Mierzejewski

“…This review aims to explain why diabetes exacerbates cardiovascular and renal diseases, leading to worse clinical outcomes in affected individuals, focusing on its pathophysiological mechanisms. Material and Methods. A systematic literature review was conducted using PubMed and Google Scholar databases. …”
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Evaluation of right ventricular-arterial coupling in chronic heart failure and pulmonary hypertension by K. V. Kondrashova, M. K. Rybakova

“…Rationale. Right ventricular dysfunction plays an important role in the course of chronic heart failure and its outcomes. …”
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Some questions about the state of the eye surface in patients before cataract surgery by N. S. Lutsenko, O. A. Isakova, O. A. Rudycheva, T. S. Kyrilova, T. S. Mihalchik

“…Conclusion. Ocular surface dysfunction is common among patients before cataract surgery, especially in diabetes mellitus. …”
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Fournier’s gangrene: the current state of the problem and our treatment experience by S. A. Aliev, E. S. Aliev

“…The OBJECTIVE of the study was to analyze the results of treatment of patients with lightning scrotal gangrene (Fournier’s gangrene).METHODS AND MATERIAL. The work is based on the analysis of the results of treatment of 31 patients with Fournier’s gangrene aged 32 to 82 years. …”
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Diagnostic capabilities of instrumental methods for studying early cardiovascular adverse events in patients with lymphoproliferative disorders, quality and safety issues by G. R. Gimatdinova, O. E. Danilova, I. L. Davydkin, U. L. Dzhulakyan, E. V. Usenko

“…To study the possibilities of instrumental research methods in relation to the earliest detection of cardiovascular events in oncohematological patients receiving antitumor immunochemotherapy, as well as to deter­mine the requirements for documenting adverse events.Material and methods. For the study, 63 patients were prospectively selected with a diagnosis of indolent non-Hodgkin lymphoma, who were indicated for antitumor immunochemotherapy. …”
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Risk factors for myocardial infarction during carotid endarterectomy in high-risk patients with coronary artery disease by A. N. Vachev, O. V. Tereshina, O. V. Dmitriev, Yu. S. Belkin, P. A. Lebedev

“…In high-risk patients with CAD, severe impairment of local LV contractility and global LV systolic dysfunction are the most significant risk factors for perioperative MI during CEA.…”
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Heart failure in cancer patients by A. F. Khalirakhmanov, A. Z. Sharafeev, G. D. Gatiyatullina, S. V. Zinchenko, R. F. Gaifullina, A. A. Rizvanov

“…The purpose of the study was to conduct a systematic review of data on the role of heart failure (HF) in the development of cancer, as well as to discuss problems dealing with diagnosis and treatment of heart failure in cancer patients. Material and methods. A literature search was conducted using the Cochrane library, elibrary, medline, and embase databases over the past 7 years. …”
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Сytokines as promising diagnostic and prognostic biomarkers of microvascular complications of diabetes by V. V. Klimontov, К. R. Mavlianov

“…It has been established that inflammatory reactions play a role in the beta cell dysfunction, the formation of insulin resistance and remodeling of the vascular wall. …”
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Blood atherogenic potential as a predictor of arterial hypertension among children living in ecologically unsafe territories of the Moldova Republic by L. V. Vasilos, M. G. Arame, A. N. Kozhokaru, A. I. Khorodishtyanu-Banukh, O. N. Kyrtsya

“…To assess the blood atherogenic potential among children living in ecologically unsafe regions and to investigate the role of metabolic disorders in the AH development. Material and methods. In total, health status was assessed in 1500 children from ecologically unsafe regions of theMoldovaRepublic. …”
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Differential beta-adrenoblocker therapy in chronic heart failure: the role of age, gender, and co-morbidity by S. N. Tereshchenko, I. V. Zhirov, A. V. Akinina, A. G. Kochetov

“…To investigate differential beta-adrenoblocker (BAB) therapy, based on clinical and demographic characteristics of the patients, as a method to optimise the management of chronic heart failure (CHF).Material and methods. The study included 90 patients: 50 men (55,6%) and 40 women (44,4%) of mean age 64,7±1,9 years. …”
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COMPARISON OF THE DISORDERED MECHANICAL FUNCTION OF THE LEFT ATRIUM AFTER ANTRAL ISOLATION OF PULMONARY VEINS BY RADIOFREQUENCY OR CRYOBALLOON ABLATION by I. N. Mamchur, T. Yu. Chichkova, S. E. Mamchur, N. S. Bokhan, M. P. Romanova, E. A. Khomenko

“…To assess and compare mechanical functioning of the left atrium before and just after cryoballoon or radiofrequency ablation.Material and methods. Totally, 43 patients included, with sympthomatic atrial fibrillation resistant to drug treatment. …”
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The role of innate immune system mediators in the development of retinal neurodegeneration in type 2 diabetes mellitus by M. P. Ruchkin, E. V. Markelova, G. A. Fedyashev, V. E. Krasnikov

“…This may indicate an important role of neuroinflammation and dysfunction of the immune system in the retinal neurodegeneration process of DM patients. …”
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Current Approaches to the Treatment of Traumatic Shock (Review) by D. A. Ostapchenko, A. I. Gutnikov, L. A. Davydova

“…Current methods of respiratory failure control allow to estimate promptly the severity of respiratory dysfunction, reveal the cause and correct existing disorders in an individualized way taking into account the better availability of mechanical ventilation. …”
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THE PREDICTIVE VALUE OF THE INDEX BAEVSKY AND ITS RELATIONSHIP WITH CLINICAL AND FUNCTIONAL DATA IN PATIENTS WITH ISCHEMIC HEART DISEASE by G. A. Nagaeva, R. D. Kurbanov, N. P. Yuldashev, N. B. Mirzaliyeva

“…Objective: to evaluate the prognostic significance Baevsky-index (BI), during the bicycle exercise test, in comparison with the data of coronary angiography (CAG) in patients with chronic ischemic heart disease. Material and methods: the study involved 116 patients with chronic ischemic heart disease (men - 84.5%) of them with angina pectoris functional class 2 - 47 (40.5%), functional class 3 - 69 (59.5 %) patients. …”
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Association of a high rate of glycolysis and the activity of the uncoupling of oxidation and phosphorylation in the blood cells of patients with late-stage knee osteoarthritis and... by E. B. Chetina, G. A. Markova, K. E. Glemba, M. A. Makarov

“…Objective: to investigate the relationship between the expression of genes mediating cellular energy production and the development of chronic postoperative pain (CPP) after total knee arthroplasty (TKA) in patients with osteoarthritis (OA).Material and methods. Prior to TKA, the blood of 50 patients with stage III–IV knee OA and complaints of constant pain and joint dysfunction was analyzed. …”
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Мodification of Mechanical Limbal Stem Cell Deficiency Model by A. V. Bezushko, A. S. Dubovikov, A. N. Kulikov, S. V. Churashov, V. F. Chernysh, A. A. Suetov, I. O. Gavriluk

“…Ocular surface diseases related with limbal epithelial stem cells dysfunction were united in term “limbal stem cell  deficiency” (LSCD). …”
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Early structural and functional left ventricular disorders in young patients with hypertension: a role of insulin resistance by E. K. Shavarova, Zh. D. Kobalava, N. E. Yezhova, I. A. Khomova, E. I. Bazdyreva

“…To analyze the associations of insulin resistance and left ventricular (LV) remodeling in a cohort of young patients with untreated uncomplicated hypertension and high normal blood pressure (BP).Material and methods. The presented cohort cross-sectional study included 105 subjects. …”
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Evaluation of ST2 as an early marker of heart failure with a preserved left ventricular ejection fraction in patients with persistent atrial fibrillation by E. A. Polyanskaya, N. A. Koziolova, S. V. Mironova

“…To assess the diagnostic value of soluble ST2 (sST2) for early detection of heart failure with a preserved ejection fraction (HFpEF) in patients with persistent atrial fibrillation (AF).Material and methods. A total of 165 patients hospitalized with AF paroxysm were examined. …”
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