EFFECT OF MITRAL REGURGITATION ON CHRONIC HEART FAILURE COURSE AND STRUCTURE-FUNCTIONAL HEART STATE by V. N. Larina, B. Y. Bart, M. P. Mikhaylusova, B. N. Mamtsev

“…The majority of patients with MR III had significant left ventricle (LV) systolic dysfunction (p=0,029), severe CHF course (p=0,034), received furosemide (p=0.004) and digoxin (p=0,004). …”
Get full text

Effects of Pelvic Floor Muscle Exercises on Sexual Function in Postmenopausal Women - a Systematic Review by Katarzyna Ślemp, Agnieszka Sozańska

“…Background: Hormonal changes associated with menopause, often lead to the development of sexual dysfunctions in women. These include lowering of the reproductive organs, urinary incontinence, recurrent infections and hormonal changes. …”
Get full text

Changes in haematological and biochemical blood parameters of C57Bl/6 mice in acute paracetamol poisoning by A. I. Zudova, E. A. Mukhlynina, I. F. Gette, L. V. Solomatina

“…After administration of paracetamol at a dose of 600 mg/kg body weight, signs of liver (change of alanine and aspartate aminotransferase activity, total protein and urea content) and kidney (creatinine level) dysfunction were detected in mice. In peripheral blood, the classic picture of inflammatory response is determined (lymphopenia and granulocytosis) with signs of impaired haemostasis in the form of thrombocytopenia. …”
Get full text

The dynamics of 24-hour ambulatory blood pressure monitoring parameters, subclinical damage and endothelial function of vessels in patients with arterial hypertension and chronic o... by O. G. Ivanko, A. V. Tovma, A. V. Kamenshchyk, M. V. Patsera

“…In case of prevalence of the clinical, laboratory and instrumental signs of broncho-obsctructive syndrome, presence of subclinical damages and elastic qualities of vessels and endothelial dysfunction in patients with AH and COPD S-amlodipine should be prescribed additionally to Enalapril and basic therapy of CODP. …”
Get full text

Comparative effects of renin-angiotensin-aldosterone system modulators on right heart function and prognosis in patients with severe systolic chronic heart failure by K. G. Adamyan, L. R. Tumasyan, A. L. Chilingaryan

“…To compare the effects of renin-angiotensin-aldosterone system (RAAS) modulators in patients with severe chronic heart failure (CHF). Material and methods. In total, 148 patients (57,4±0,4 years), with severe systolic left ventricular (LV) dysfunction (ejection fraction (EF) <40%) were randomized into 4 groups: Group A (n=38), receiving only ACE inhibitors; Group B (n=37), receiving spironolactone (up to 50 mg); Group C (n=37), receiving valsartan (up to 320 mg); and Group D (n=36), receiving aliskiren (up to 300 mg), in addition to ACE inhibitors, diuretics, b-adrenoblockers, and digoxin. …”
Get full text

THE ROLE OF MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORS IN THE DEVELOPMENT OF COMPLICATIONS OF KIDNEY DISEASE IN CHILDREN by G. A. Sukhanova, A. A. Terent’eva, N. N. Kuvshinov

“…Disbalance between MMP and TIMP accompanied by the accumulation of extracellular matrix, increases the risk of chronic renal failure.The purpose of the study – to assess the role of MMP and TIMP involved in the processes of inflammation and resulting to renal dysfunction in glomerulonephritis and pyelonephritis in children.Material and methods. …”
Get full text

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities by Yun Liao, Stacia Octaviani, Zhen Tian, Samuel R. Wang, Chunlan Huang, Jian Huang

“…Furthermore, the potential role of MQC dysfunction in hematopoietic disorders, including its involvement in disease progression and therapeutic resistance, is not yet fully understood. …”
Get full text

Modern approaches to transvenous lead extraction by D. G. Podolyak, A. Yu. Kiprensky, S. A. Mironovich

“…To show the effectiveness and safety of modern transvenous lead extraction (TLE) techniques used in cardiac surgery.Material and methods. The study included 102 patients (men — 66, women — 36; mean age 58,3±1,7 years). …”
Get full text

Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities by Amal Abdelmonem Halawa, Gehad Elshopakey, Mohamed El-Adl, Samah Lashen, Nancy Shalaby, Shaymaa Rezk, Omar Elmetwally, Ehab Eldomany, Ahmed Farghali, Mohamed Elmetwally

Get full text

Accelerated peripheral nerve repair using surface-modified biomaterials for targeted capture of glial-derived growth factors post-neurorrhaphy. by Shiu-Jau Chen, Chih-Ming Lin, Chiung-Hui Liu, Yin-Hsiu Chen, Yu-Lin Hsieh, You-Cheng Lin, Yin-Hung Chu, Chung-Yao Ku, Wei-Li Liao, Wen-Chieh Liao

“…Peripheral nerve injury (PNI) commonly leads to motor or sensory dysfunction, with nerve grafts being the standard treatment for neurorrhaphy. …”
Get full text

Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with N... by Fan Yang, Kailun Zhang, Xiaohua Dai, Weimin Jiang

“…Research in clinical settings has revealed that Yanggan Yishui Granule (YGYSG) has significant therapeutic effects on HN. However, the material basis and action mechanisms of YGYSG against HN remain unclear. …”
Get full text

Central Hemodynamics and Intracranial and Cerebral Perfusion Pressures in Acute Cerebral Circulatory Disorders by K. V. Lukashev, A. Z. Valiakhmedov, Yu. A., Churlyaev, L. Yu. Redkokasha, T. I. Borshchikova, P. G. Sitnikov, T. P. Aikina

“…CPP was significantly unchanged. Myocardial dysfunction was detected when there was a significant preload caused by a high postload. …”
Get full text

Seroprevalence of scrub typhus among patients with acute febrile illness: A study from northern districts of West Bengal by Santanu Hazra, Arpita P. Dutta, Sumana Moitra, Shampa Das, Sanjoy K. Mallick, Arunabha Sarkar, Binita Pradhan, Ayan Chakraborty, Debapriya Bhowmick, Arnab Saha

“…Untreated or undiagnosed cases can be complicated with myocarditis, pneumonia, acute kidney injury, meningoencephalitis, gastrointestinal bleeding, and multi-organ dysfunction syndrome. Antibody-based serological tests or IgM Enzyme-Linked Immunosorbent Assay against Orientia tsutsugamushi is a standard test for the diagnosis of scrub typhus within the first week of illness. …”
Get full text

Cardiac magnetic resonance imaging in mortality risk stratification of patients with pulmonary hypertension by N. S. Goncharova, A. V. Ryzhkov, K. B. Lapshin, A. F. Kotova, O. M. Moiseeva

“…To compare cardiac magnetic resonance imaging (MRI) parameters with known prognosis determinants in patients with pulmonary hypertension (PH).Material and methods. This prospective single-center study included 60 patients with PH aged 21-72 years. …”
Get full text

Postprandial hyperlipidemia as a coronary atherosclerosis factor in patients with metabolic syndrome; corrective potential of rosuvastatin therapy by T. V. Krovyakova, P. A. Lebedev

“…Material and methods. The first study phase included 18 CHD and MS-free participants (control group, CG) and 52 patients with CHD and MS. …”
Get full text

The Impact of a Comprehensive Intervention on Sensorimotor Recovery in Cerebro Vascular Accident (CVA) Patients in Selected Hospitals, Coimbatore, Tamil Nadu by Deepa Ramaswamy, Arockiamary Ignasimuthu, S. Parimala, Lingaraj Chitra, Sasikala Gunasekaran, Panneerselvam Periasamy

“…Introduction: A cerebrovascular accident (CVA) occurs when a blood clot blocks oxygen and blood flow to the brain, causing physical limitations, sensory dysfunction, headaches, and incontinence in patients. …”
Get full text

New perspectives in immunological diagnostics of coronary heart disease by S. I. Davydov, A. A. Tarasov, A. L. Emelyanova, M. A. Kiseleva, A. R. Babaeva

“…Material and methods. The study included 455 patients with various clinical variants of CHD. …”
Get full text

Еprosartan therapy effectiveness in arterial hypertension patients after stroke or transient ischemic attack by Yu. M. Pozdnyakov, A. M. Urinsky, R. L. Kuznetsov, S. V. Belonosova, I. B. Ryzhikova, I. D. Bondarenko, O. V. Patrikhalkina

“…Moreover, in Group I, depression and cognitive dysfunction levels substantially decreased. Conclusion. …”
Get full text

Two strategies for arterial hypertension treatment in patients with secondary chronic pyelonephritis by M. E. Statsenko, M. V. Derevyanchenko

“…In both groups, there was a decrease in the number of patients with circadian BP rhythm disturbances, adverse left ventricular remodelling types, or diastolic dysfunction. The combination of enalapril and indapamide was significantly more effective in terms of restoring renal concentrating function, compared to the combination “enalapril + nifedipine SR”. …”
Get full text

Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthri... by A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, S. A. Yanchenkova

“…Outcomes were assessed after 3 months using the dynamics of pain, fatigue, dysfunction (according to NRS), and the “Patient Acceptable Symptom State” (PASS) indicator.   …”
Get full text