Spontaneous Fungal Peritonitis versus Fungiascites by Carlos F. Fajardo – Felix, Elda V. Rodríguez – Negrete, Patricia Manzano – Gallosso, Francisca Hernandez – Hernandez

“…Describe the characteristics of the patients with spontaneous fungal peritonitis or fungiascites. Materials and Patients: Three cases are presented. …”
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Saline nasal irrigation and gargling in COVID-19: Part II. Outcomes in Omicron and risk–benefit for self-care by S. Huijghebaert, C. Fabbris, C. Fabbris, A. L. Baxter, S. Parviz, U. S. Chatterjee, D. Rabago

“…If clean water and irrigation materials are provided, SNI can reasonably be recommended as early self-care for COVID-19, as it is for the common cold. …”
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A Comparative Study of Regional Cerebral Blood Flow Asymmetry Index in Stroke Patients with or without Poststroke Depression Using 99mTc-ECD Single-Photon Emission Computed Tomogra... by Pradeep Kumar Maurya, Abdul Qavi, Satyawati Deswal, Ajai Kumar Singh, Dinkar Kulshreshtha, Anup Kumar Thacker

“…This may reflect the dysfunction of the limbic system and contribute to the occurrence of PSD.…”
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Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload by Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY

“…The aim of the study was to design and synthesize novel hybrid molecules to improve HT’s biological efficiency.Materials and Methods: A pharmacophore connection strategy was used to design and synthesize novel hybrid molecules by combining HT or its analogues with adamantane (ADM). …”
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HDL-C and BMI levels as parameters for MASLD detection by Stefanny Cornejo-Hernández, Esly Esquivel-Alarcón, Reyna Hernández-Espinoza, J. Salvador García-Hernández, Trinidad Baldovinos-Hernández, Javier Bastida-Alquicira, Eira Cerda-Reyes, Adriana Martinez-Cuazitl

“…Introduction and Objectives: Hepatic Steatosis Associated with Metabolic Dysfunction (MASLD) has a prevalence of 30% worldwide and 80% of these patients do not present alterations in liver biochemistry, therefore it is important to know if there is any biochemical parameter that helps us identify this population. …”
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Efficacy of Corticosteroid Therapy in Severe Community-acquired Pneumonia: A Monocentric Single-blinded Randomized Placebo-controlled Trial from a Tertiary Care Center in North Ind... by Anurag Dahra, Vidiyala Sai Sandeep, Kamal Singh, Pritam Singh, Mandeep Singla

“…Aim and background: A dysregulated immune response can produce acute lung injury and worsen clinical status of patient by causing organ dysfunction and severe pneumonia. Modulating the immune response can improve the outcome of illness and avoid treatment failures. …”
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HISTOGENETIC ASPECTS OF PNEUMOFIBROSIS DURING CONIOTIC CHANGES IN KUZBASS MINERS by Олег Иванович Бондарев, Сергей Николаевич Филимонов

“…The aim of the study was to identify trigger morphological mechanisms of the development of oncological pathology in miners with signs of pneumofibrosis, based on pathomorphological, immunohistochemical studies of changes in the tissue of the airways during epithelial-mesenchymal transformation, apoptotic activity, proliferation of smooth muscle cells (MMC) and endothelial dysfunction. Materials and methods. Histological, morphometric and immunohistochemical studies of pulmonary histione obtained during 60 autopsy operations of a group of Kuzbass miners. …”
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Laser technologies in surgery for benign prostate hyperplasia by S. A. Rakhimov, I.  V. Feofilov, I. A. Arbuzov

“…To compare the effectiveness and safety of laser technologies using the example of the use of diode and thulium lasers in BPH surgery.Materials & methods. The study included 89 men with BPH who underwent surgery from 2020 to 2022. …”
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Prognostic significance of the biomarker NT-proBNP in the surgical treatment of aortic stenosis (pilot study) by I. A. Kozlov, L. A. Krichevsky, V. Yu. Rybakov

“…The objective was to study the relationship between the preoperative blood levels of the N-terminal segment of B-type natriuretic peptide precursor (NT-proBNP) and ultrasound and thermodilution indicators of cardiac function before and after on-pump surgery for aortic stenosis, as well as to evaluate the prognostic significance of the biomarker in relation to postoperative myocardial dysfunction.Materials and methods. The study involved 27 patients aged 57.7±2.5 years who underwent aortic valve replacement. …”
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Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia by Elena Timokhina, Alexander Strizhakov, Sapiyat Ibragimova, Evgeny Gitel, Irina Ignatko, Vera Belousova, Nikoleta Zafiridi

“…The object of the present study was to reveal the role of MMP-2 and MMP-9 in the development of severe preeclampsia. Materials and Methods. We conducted a retrospective study that included 92 pregnant women at a gestational age of 26-38 weeks, of which the principal group consisted of 61 patients with severe PE. …”
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Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy by Guanchen Sha, Yuefan Liu, Yutong Cao, Qi Zhang, Yining Zhang, Yuanyuan Chen, Qiuyun Fan, Yue Cheng

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Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway by Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang

“…This study investigates the mechanisms of celastrol-induced immunotoxicity, focusing on the PI3K-Akt signaling pathway, a key regulator of immune function.Materials and methodsAn integrative approach combining network toxicology, molecular docking, and experimental biology identified molecular targets in celastrol-induced immune dysfunction. …”
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Enhancing personalised care in COPD exacerbation: the role of cardiac/inflammatory biomarkers by Pouria Khashayar, Kenneth Spearpoint, Patricia Khashayar, Manivannan Srinivasan, Thida Win

“…The relationship between COPD and cardiovascular diseases (CVD) is well established, with many studies confirming comorbidities, such as coronary artery disease, heart failure and diabetes mellitus, to significantly impact their prognosis.2,3 Thus, the role of cardiac dysfunction in increasing the mortality rate (between 30% and 60%) in COPD individuals is well documented and known to be closely linked to advancing age as well as long-term disabilities and, therefore, is a tremendous burden on society.4 Materials and Methods: A systematic literature review in PubMed and Web of Science using keywords including ‘Exacerbated COPD’, cardiovascular events such as ‘cardiovascular mortality’, ‘coronary heart disease’, ‘CVD’, ‘myocardial ischemia’ and ‘heart failure’ and cardiac/inflammatory biomarkers (‘Troponin’, ‘B-Type Natriuretic Peptide (BNP)’ and ‘C-Reactive Protein (CRP)’) was undertaken to help provide a better picture of this association. …”
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Placental markers of miscarriage by A. A. Zhyvetska-Denysova, I. I. Vorobiova, N. Ya. Skrypchenko, S. M. Tolkach, S. M. Razdaibedin, Yu. M. Bondarenko

“…The aim of the work is to identify the markers of miscarriage and premature labor in the structures of the chorion and placenta. Materials and methods. The main group included tissue samples of the 22 chorions and 64 placentas after termination of current pregnancy from women with a history of reproductive losses. …”
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Evaluation of echocardiographic parameters in patients of acute right ventricular myocardial infarction and its association with in-hospital outcome by Anubhav Prakash, Pradip Saha, Pradip Kumar Ghoshal, Goutam Datta, Saroj Mondal, Abhisek Naskar, Bablu Nandi

“…Materials and Methods: The study is a prospective observational cross-sectional analysis conducted at the public sector apex institute in eastern India, involving 155 patients diagnosed with acute IWMI/RVMI. …”
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Phenotypic clusters and biomarkers profile in patients with chronic heart failure with preserved and mildly reduced left ventricular ejection fraction by Natalia A. Dragomiretskaya, Anastasia V. Tolmacheva, Alexander A. Ivannikov, Ilya I. Shvedov, Artyom V. Belyakov, Kamila R. Agalarova, Valery I. Podzolkov

“…To study the profile of cardiac biomarkers (NT-proBNP – N-terminal pro-brain natriuretic peptide, sST2 – soluble growth stimulation expressed gene 2, galectin-3, copeptin) in clusters of patients with chronic heart failure with preserved (CHFpEF) and mildly reduced (CHFmrEF) left ventricular (LV) ejection fraction (EF). Materials and methods. The study included 135 patients with CHF and LV EF40%. …”
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First trimester thyroid function in pregnant women residing in Saint Petersburg (Russia): reference values and risk of gestational diabetes by Polina V. Popova, Ekaterina S. Shilova, Alexandra S. Tkachuk, Alexandra V. Dronova, Anna D. Anopova, Alla E. Nikolaeva, Elena N. Grineva

“…The concept of subclinical dysfunction of the thyroid gland in pregnant women depends on the population-specific and trimester-specific reference values so fixed universal cutoff concentrations for thyroid-stimulating hormone (TSH) that were recommended earlier now are put under the question. …”
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Correlation between mitral annular plane systolic excursion (MAPSE) at different degrees of ejection fraction in patients with diabetes mellitus by Muhammad Rido, Khalid Saleh, A. Makbul Aman, Syakib Bakri, Haerani Rasyid, Andi Alfian Zainuddin

“…Early detection of cardiac dysfunction is crucial for timely intervention and improved patient outcomes. …”
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Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling by Xuan Li, Ziyu Kong, Ke Cai, Fujian Qi, Sen Zhu

“…Hippocampus is an important region of the brain for learning, memory, and emotions. Dysfunction of hippocampus can lead to severe learning and memory disorder, significantly affecting quality of life. …”
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EFFECTIVENESS OF PHARMACOTHERAPY FOR NORMALIZATION OF THE BRAIN NATRIURETIC PEPTIDE, RENINE-ANGIOTENSINALDOSTERONE SYSTEM ACTIVATION AFTER SURGICAL REVASCULARIZATION OF MYOCARDIUM... by S. A. Kovalev, V. Е. Malikov, V. Yu. Merzlyakov, A. A. Bulynin, A. В. Bulynin, E. A. Krasyukova, E. V. Malyutin, М. А. Arzumanyan

“…The  research  on  medical  technologies   for  optimization  of complication prevention and of post-surgery management of patients with coronary heart disease  (CHD) with ejection fraction (EF) of the left ventricle (LV) <40% in surgical revascularization of the heart. Material and methods. In the controlled, randomized study of 103 CHD patients with severe systolic dysfunction of the LV, the effectiveness  of aortic  coronary  bypass  surgery  was  studied.  …”
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